Xulei Zuo

ORCID: 0000-0003-2235-681X
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About
Contact & Profiles
Research Areas
  • Immune Response and Inflammation
  • Immune cells in cancer
  • Ferroptosis and cancer prognosis
  • Drug Transport and Resistance Mechanisms
  • Epigenetics and DNA Methylation
  • MicroRNA in disease regulation
  • Pharmacovigilance and Adverse Drug Reactions
  • Wnt/β-catenin signaling in development and cancer
  • Inflammasome and immune disorders
  • Additive Manufacturing and 3D Printing Technologies
  • Drug-Induced Adverse Reactions
  • Heme Oxygenase-1 and Carbon Monoxide
  • Food Quality and Safety Studies
  • Traditional Chinese Medicine Analysis
  • Biosimilars and Bioanalytical Methods
  • interferon and immune responses
  • 3D Printing in Biomedical Research
  • Metabolomics and Mass Spectrometry Studies
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Mosquito-borne diseases and control
  • Animal testing and alternatives
  • Cancer-related gene regulation
  • Eicosanoids and Hypertension Pharmacology
  • Advanced Glycation End Products research
  • Tea Polyphenols and Effects

Anhui Medical University
2022-2024

Southeast University
2024

We have previously shown that excessive activation of macrophage proinflammatory activity plays a key role in TCE-induced immune liver injury, but the mechanism polarization is unclear. Recent studies TLR9 an important regulatory polarization. In present study, we demonstrated elevated levels oxidative stress hepatocytes mediate release mtDNA into bloodstream, leading to macrophages regulate vivo experiments revealed pretreatment with SS-31, mitochondria-targeting antioxidant peptide,...

10.1016/j.ecoenv.2024.116317 article EN cc-by-nc Ecotoxicology and Environmental Safety 2024-04-13

This study aimed to investigate the activating mechanism of NLRP3 inflammasome in trichloroethylene-sensitized mice. In total, 88 BALB/c female mice were used establish trichloroethylene (TCE)-sensitized mouse model. Some received MitoTEMPO, MCC 950 or soluble recombinant CD59-Cys inhibit mitochondrial reactive oxygen species (mtROS) production, assembly, C5b-9 formation. Mouse tubular epithelial cell expression levels NLRP3, ASC, Caspase 1, IL-1β, IL-18 and antiviral signaling protein...

10.1016/j.ecoenv.2022.114067 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2022-09-07

Patients with occupational medicamentose-like dermatitis due to trichloroethylene often suffer from immune kidney injury. Our previous study reveals that C5b-9-dependent cytosolic Ca2+ overload-induced ferroptosis is involved in sensitized However, how C5b-9 causes rise and the specific mechanism whereby overloaded induces remain unknown. The purpose of our was explore role IP3R-dependent mitochondrial dysfunction mediated kidney. results showed IP3R activated, membrane potential decreased...

10.3389/fimmu.2023.1106693 article EN cc-by Frontiers in Immunology 2023-06-13

Occupational medicamentose-like dermatitis due to trichloroethylene (OMDT) is a key but unresolved question. OMDT patients often present multiple organ damage, including kidney damage. However, the underlying mechanism remains unknown. The purpose of our study was explore effect tubule-specific C5b-9 deposition induced by TCE sensitization on renal tubular ferroptosis and its mechanism. By analyzing pathological changes TCE-sensitization-mice kidney, we observed significant ferroptosis,...

10.1016/j.ecoenv.2022.114020 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2022-08-29

Upadacitinib, a Janus kinase (JAK) inhibitor, has been approved by the FDA to treat various autoimmune conditions. This study assessed its adverse events analyzing reports from Adverse Event Reporting System (FAERS).

10.1002/pds.70030 article EN Pharmacoepidemiology and Drug Safety 2024-10-01

Abstract Background & Aims: Trichloroethylene (TCE) is a commonly used organic solvent in industry. Our previous studies have found that TCE can cause liver injury accompanied by macrophage polarization, but the specific mechanism unclear. The epigenetic regulation of polarization mainly focused on histone modification. Histone lysine demethylase 4A (KDM4A) involved activation macrophages. In this study, we mouse model investigated role KDM4A liversof TCE-drinking mice and expression...

10.21203/rs.3.rs-3323067/v1 preprint EN cc-by Research Square (Research Square) 2023-10-11
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