A5100608010- Immune Response and Inflammation
- Immune cells in cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Astro and Planetary Science
- Inflammasome and immune disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Complement system in diseases
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Drug Transport and Resistance Mechanisms
- Extracellular vesicles in disease
- interferon and immune responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Respiratory viral infections research
- Blood Coagulation and Thrombosis Mechanisms
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2019-2025
University of Chinese Academy of Sciences
2025
First Hospital of Jilin University
2025
Jilin University
2025
Institute of Virology of the Slovak Academy of Sciences
2025
Shanghai Institute of Microsystem and Information Technology
2025
Chinese Academy of Sciences
1994-2025
Shanghai First People's Hospital
2019-2024
Shaanxi University of Chinese Medicine
2022-2024
Abstract Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) important players involved many biological processes. circHIPK3 has been identified as one of most abundant circRNAs human lung. In this study, we characterized role We revealed that is upregulated bleomycin-induced fibrosis mice model, FMT-derived myofibroblasts. silencing can ameliorate FMT...
Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal lung disease characterized by progressive and non-reversible abnormal matrix deposition in parenchyma. Myofibroblasts originating mainly from resident fibroblasts via fibroblast-to-myofibroblast transition (FMT) are the dominant collagen-producing cells fibrosis. N6-methyladenosine (m6A) modification has been implicated various biological processes. However, role of m6A remains elusive. In this study, we reveal that upregulated...
The ability to control nonclassical light emission from a single quantum emitter by an integrated cavity may unleash new perspectives for photonic applications. However, coupling within circuitry towards creation of the Purcell-enhanced single-photon is elusive due complexity integrating active devices in low-loss circuits. Here we demonstrate hybrid micro-ring resonator (HMRR) coupled with self-assembled dots (QDs) cavity-enhanced deterministic emission. HMRR supports whispering-gallery...
Asthma is one of the most common inflammatory diseases characterized by airway hyperresponsiveness, inflammation, and remodeling. Morin, an active ingredient obtained from Moraceae plants, has been demonstrated to have promising anti‐inflammatory activities in a range disorders. However, its impacts on pulmonary diseases, particularly asthma, not clarified. This study was designed investigate whether morin alleviates inflammation chronic asthma with emphasis oxidative stress modulation. In...
Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus (H1N1), a single-stranded, negative-sense RNA with an eight-segmented genome, enhanced glycolysis both in mouse lung tissues human epithelial (A549) cells. detail, expression of hexokinase 2 (HK2), first enzyme glycolysis, was upregulated H1N1-infected A549 cells, pyruvate kinase M2 (PKM2) dehydrogenase 3 (PDK3)...
Abstract Background Our goal is to further elucidate the clinical condition and prognosis of patients with severe acute COVID-19 EBV reactivation. Method This a retrospective single-center study admitted intensive care unit Wuhan No. 3 Hospital (January 31 March 27, 2020). According whether Epstein-Barr virus reactivation was detected, were divided into an group Non-EBV group. Baseline data collected including epidemiological, larithmics, imaging characteristics, laboratory examination data....
Gastric mucosal injury is a chronic and progressive stomach disease that can be caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Therefore, there an urgent need to find safe effective prevent gastric due NSAIDs. Cinnamaldehyde (CA) bioactive compound extracted from the rhizome of cinnamon has various pharmacological functions, including anti-inflammatory, analgesic, antiapoptotic, antioxidant activities. However, potential effect CA on remains unknown.
Trichloroethylene (TCE) is a major occupational hazard and environmental contaminant that can cause multisystem disorders in the form of medicamentosa-like dermatitis. Development dermatitis involves several proinflammatory cytokines, but their role TCE-mediated has not been examined well-defined experimental model. In addition, few animal models TCE sensitization are available, current guinea pig model apparent limitations. This study aimed to establish TCE-induced skin BALB/c mice examine...
We have previously shown that excessive activation of macrophage proinflammatory activity plays a key role in TCE-induced immune liver injury, but the mechanism polarization is unclear. Recent studies TLR9 an important regulatory polarization. In present study, we demonstrated elevated levels oxidative stress hepatocytes mediate release mtDNA into bloodstream, leading to macrophages regulate vivo experiments revealed pretreatment with SS-31, mitochondria-targeting antioxidant peptide,...
Trichloroethylene (TCE), a widely distributed environmental chemical contaminant, is extensively dispersed throughout the environment. Individuals who are exposed to TCE may manifest occupational medicamentose-like dermatitis due trichloroethylene (OMDT). Renal impairment typically manifests in initial phase of OMDT and intricately linked disease progression patient outcomes. Although recombinant human tumor necrosis factor-α receptor II fusion protein (rh TNFR:Fc) has been employed clinical...
Gastric precancerous lesions (GPL) precede the development of gastric cancer (GC). They are characterized by mucosal intestinal metaplasia and dysplasia caused various factors such as inflammation, bacterial infection, injury. Abnormalities in autophagy glycolysis affect GPL progression, their effective regulation can aid treatment GC prevention. Xiaojianzhong decoction (XJZ) is a classic compound for digestive system diseases ancient China which inhibit progression GPL. However, its...
Abstract Objective The study aimed to explore the effectiveness of bedside lung ultrasound (LUS) combined with PaO 2 /FiO (P/F) ratio in evaluating outcomes high-flow nasal cannula (HFNC) therapy infants severe pneumonia. Methods This retrospective analyzed clinical data 150 diagnosed pneumonia and treated HFNC at our hospital from January 2021 December 2021. These patients were divided into two groups based on their treatment outcomes: success group ( n = 112) failure 38). LUS was utilized...
The effect of 3′-azido-3′-deoxythymidine (AZT) on in vitro infection peripheral blood mononuclear cells (PBMCs) isolated from normal adult individuals with human T cell leukaemia/lymphoma virus type I (HTLV-I) was evaluated. Different PBMC samples were exposed to HTLV-I by cocultivation MT-2 (a chronically infected line) the presence 20 U/ml recombinant interleukin 2 (IL-2) and graded concentrations AZT. Control drug-treated cultures, both uninfected PBMCs, then grown for several weeks...
Abstract We have previously shown complement activation as a possible mechanism for trichloroethylene (TCE) sensitization, leading to multi‐organ damage including the kidneys. In particular, excessive deposition of C5 and C5b‐9‐the membrane attack complex, which can generate significant tissue damage, was observed in kidney after TCE sensitization. The present study tested hypothesis that anaphylatoxin C5a binding its receptor C5aR mediates renal injury TCE‐sensitized BALB/c mice. mice were...
Bronchial asthma, one of the most common allergic diseases, is characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling.The anti-oxidant flavone aglycone diosmetin ameliorates inflammation in pancreatitis, but little known about its impact on asthma.In this study, effects chronic asthma were investigated with an emphasis modulation remodeling BALB/c mice challenged ovalbumin (OVA).It was found that significantly relieved inflammatory cell infiltration, goblet...
Abstract Objective The disruption of metabolic events and changes to nutrient oxygen availability due sustained inflammation in RA increases the demand bioenergetic biosynthetic processes within damaged tissue. current study aimed understand molecular mechanisms SLC7A5 (amino acid transporter) synoviocytes patients. Methods Synovial tissues were obtained from OA Fibroblast-like (FLS) isolated, expression was examined by using RT-qPCR, immunofluorescence, Western blotting. RNAi antibody...
Background: Early identification of sepsis improves the survival rate; however, it is one most challenging tasks for physicians, especially since symptoms are easily confused with those systemic inflammatory response syndrome (SIRS). Our aim was to explore biomarkers early that would aid in its differential diagnosis. Methods: Eight patients SIRS, eight sepsis, and healthy controls were included this study. Metabolites screened using gas chromatography-mass spectrometry (GC-MS). Metabolism...
Xiaojianzhong decoction (XJZD), classically prescribed in Chinese medicine, has protective and healing effects on gastric mucosal injury. However, the exact mechanism behind this effect remains unclear.To investigate of XJZD injury explore its underlying mechanisms.C57BL/6 mice were randomized into six groups (n = 10): control group receiving sterile water, model (aspirin 300 mg/kg), high-dose (12 g/kg), medium-dose (6 low-dose (3 g/kg) omeprazole (20 mg/kg) groups, by gavage daily for 14...
Abstract Trichloroethylene (TCE) is a commonly used organic solvent in industry. Our previous studies have found that TCE can cause liver injury accompanied by macrophage polarization, but the specific mechanism unclear. The epigenetic regulation of polarization mainly focused on histone modification. Histone lysine demethylase 4A (KDM4A) involved activation macrophages. In this study, we mouse model investigated role KDM4A livers TCE‐drinking mice and expression KDM4A, M1‐type indicators,...