A5037461420- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Genital Health and Disease
- Carcinogens and Genotoxicity Assessment
- Cervical Cancer and HPV Research
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Advanced Proteomics Techniques and Applications
- Molecular Biology Techniques and Applications
- Acute Myeloid Leukemia Research
- Urologic and reproductive health conditions
- Primate Behavior and Ecology
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Advanced biosensing and bioanalysis techniques
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Viral-associated cancers and disorders
- Salivary Gland Disorders and Functions
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Cytomegalovirus and herpesvirus research
- Telomeres, Telomerase, and Senescence
- Glutathione Transferases and Polymorphisms
- Ferroptosis and cancer prognosis
Universidade do Estado do Rio de Janeiro
2015-2025
Palm Beach Atlantic University
2024
Universidade Federal Fluminense
2012-2024
Shiv Nadar University
2023
Universidade Federal do Rio de Janeiro
1987-2022
Instituto Nacional do Câncer
2006-2017
Hospital do Câncer III
2009-2016
National Cancer Institute
2013
Armed Forces Institute of Pathology
1994-1998
Gonçalves L da R, Soares MR, Nogueira FCS, Garcia CHS, Camisasca DR, Domont G, Feitosa ACR, Pereira DA, Zingali RB, Alves G. Analysis of the salivary proteome in gingivitis patients. J Periodont Res 2011; 46: 599–606.©2011 John Wiley & Sons A/S Background and Objective: Gingivitis is a disease that characterized by inflammation gingival tissue, which can progress to periodontitis tooth loss. Although many studies have attempted identify proteins are associated with disease, this first study...
Chronic exposure of BTX (benzene, toluene, xylene) may lead to progressive degeneration bone marrow, aplastic anemia and/or leukemia. In Brazil there is no self-service fuel in gas stations and attendants fill the themselves. Due this they are chronically exposed high concentration BTX. Occupational benzene has been associated with increased chromosomal aberrations peripheral blood lymphocytes. Fluorescence situ hybridization (FISH) using whole chromosome painting (wcp) probes allows rapid...
In various solid tumors and corresponding cell lines, prior research has identified acquired copy number variations (CNVs) encompassing centromeric satellite-DNA sequences. This observation emerged from the application of probes (satellite-DNA) as controls in molecular cytogenetic investigations diagnostics, although these accounts were largely anecdotal. this study, we conducted a systematic screening for sequence amplification 31 prostate cancer (PCa) samples, prevalent malignancy men...
Osteosarcoma (OS) is the most common malignant bone tumor affecting adolescents and young adults it usually occurs in long bones of extremities. The detection cancer‑related genetic alterations has a growing effect guiding diagnosis, prognosis targeted therapies. However, little known about molecular aspects involved etiology progression OS, which limits options for present study described case an adolescent patient (16‑years‑old) who was diagnosed with conventional central OS right distal...
Recently, we were able to show that satellite DNA amplification (satDNA-AMP) is present in advanced prostate cancer. A chromosome microarray study provided first evidence satDNA-AMP appears be largely independent of centromere-near/pericentric euchromatic copy number alterations. Therefore, it might carefully suggested could a new and marker for tumor progression:
INTRODUÇÃO: O carcinoma basocelular (CBC) é a forma mais prevalente de câncer pele e caracterizado pelo crescimento lento baixa probabilidade metástase. Ainda que ele possua um curso clínico indolente quando comparado com o melanoma, por exemplo, desafio devido sua alta incidência ao impacto estético acarreta sobretudo apresentar-se em áreas visíveis à exposição solar.Tais fatores corroboram para necessidade uma compreensão detalhada abordagens preventivas, diagnósticas terapêuticas....
INTRODUÇÃO: A doença do refluxo gastroesofágico (DRGE) acontece quando o ácido estômago volta para esôfago, causando sintomas como azia e regurgitação. Isso pode ocorrer devido ao relaxamento esfíncter esofágico inferior, presença de hérnia hiato, obesidade ou hábitos alimentares inadequados. O diagnóstico é feito com base nos exames a endoscopia digestiva alta pHmetria. tratamento inclui mudanças no estilo vida, uso medicamentos os inibidores da bomba prótons e, em casos mais graves,...
No AccessJournal of UrologyAdult Urology1 Jun 2016High Risk Human Papillomavirus Infection the Foreskin in Asymptomatic Men and Patients with Phimosis Larissa A. Afonso, Thaissa I. Cordeiro, Fernanda N. Carestiato, Antonio Augusto Ornellas, Gilda Alves, Sílvia M.B. Cavalcanti AfonsoLarissa Afonso Department Microbiology Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil , CordeiroThaissa Cordeiro CarestiatoFernanda Carestiato OrnellasAntonio Ornellas Urology,...
Coronavirus disease 2019 (COVID-19) is caused by the new coronavirus 2 (severe acute respiratory syndrome - SARS-CoV-2). Long COVID a condition associated with persistent COVID-19 symptoms and/or emerging symptoms. Telomeres are specialised structures for genome protection at end of chromosomes and telomerase enzyme that synthesises telomere DNA. Patients were recruited Pedro Ernesto University Hospital (HUPE) in Rio de Janeiro, Brazil, main purpose investigating association between length...
Penile cancer is a potentially mutilating disease. Although its occurrence relatively rare worldwide, penile rates can be high in developing countries. A few studies have been conducted on the involvement of human papillomavirus (HPV) carcinoma, which found HPV present 30-70% malignant lesions, with higher prevalence 16 and 18. It has assumed that cofactors, such as Epstein-Barr virus (EBV) infections, may play role progression neoplasia. The aim this study was to determine EBV 135 lesions...
Abstract To obtain more information on chromosomal changes in the up‐to‐now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed a comparative genomic hybridization study 26 cases this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected other SCC types, such as oral and esophageal SCC, were noted. The most common gains found 8q24, 16p11–12, 20q11–13, 22q, 19q13, 5p15, deletions 13q21–22, 4q21–32, along X chromosome. Classifying...
Members of the Herpesviridae family have been implicated in a number tumours humans. At least 75% human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for presence HCMV DNA sequences. was detected 36% (27/75) biopsies. It is possible that could be co-factor evolution brain tumours.
Blood doping represents one main trend in strategies. refers to the practice of boosting number red blood cells (RBCs) bloodstream order enhance athletic performance, by means transfusions, administration erythropoiesis-stimulating substances, substitutes, natural or artificial altitude facilities, and innovative gene therapies. While detection recombinant EPO homologous transfusion is already feasible through electrophoretic, mass spectrometry flow cytometry-based approaches, no method...
The present study evaluated the proteomic profile of saliva and plasma from women with impalpable breast lesions using nano-liquid chromatography-quadrupole-time-of-flight (nLC-Q-TOF) technology. Plasma patients fibroadenoma (n=10), infiltrating ductal carcinoma (n=10) healthy control groups (n=8) were assessed by combinations inter/intra‑group analyses, revealing significant quantitative qualitative differences. major differentially-expressed proteins in compared controls α2-macroglobulin...
Different kinds of constitutive heterochromatin variation were observed in 72 specimens <i>Cebus apella, </i>belonging to five distinct subspecies, captured four geographic regions South America. One particular chromosome type, affecting pair 19, was found be exclusive one subspecies (<i>Cebus apella paraguayanus</i>) and have a distribution significantly different from that expected at equilibrium. Conversely, some other polymorphisms more widespread, with...
<b>Background: </b>This paper describes the transmission of hepatitis A virus (HAV) to two blood recipients from a healthy donor that later presented bank with jaundice. <b>Methods:</b> The RNA HAV was detected by qualitative nested reverse transcription polymerase chain reaction (nested RT-PCR) and quantified real-time RT-PCR. samples were genotyped direct sequencing PCR products. sequence fragment 168 bp VP1/2A region used construct phylogenetic tree. <b>Case...
Little is known about penile carcinogenesis. The aim of this study was to evaluate the prevalence HPV and EBV, methylation status p16 ink4a in cancer samples, contribute understanding mechanisms responsible for development. DNA detected 63.6% 122 cases, with HPV16 being most prevalent type. EBV 47.7%, EBV‐1 HPV/EBV co‐infections were found 27.3% cases. Hypermethylation 64.5% 110 tested An association between absence hypermethylation also found. Death and/or progressive disease associated...