A5101690541- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Magnesium Alloys: Properties and Applications
- Aluminum Alloy Microstructure Properties
- Aluminum Alloys Composites Properties
- Molecular Biology Techniques and Applications
- Evolution and Genetic Dynamics
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Radiomics and Machine Learning in Medical Imaging
- CRISPR and Genetic Engineering
- Machine Learning in Bioinformatics
- High Altitude and Hypoxia
- Environmental DNA in Biodiversity Studies
- Infective Endocarditis Diagnosis and Management
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- High Temperature Alloys and Creep
- Nicotinic Acetylcholine Receptors Study
- PARP inhibition in cancer therapy
- Microbial Inactivation Methods
- Solidification and crystal growth phenomena
- Heme Oxygenase-1 and Carbon Monoxide
- Magnetic and Electromagnetic Effects
Shanghai Ocean University
2025
Xi'an Jiaotong University
2011-2025
National Science Library
2025
University of Chinese Academy of Sciences
2025
The University of Texas MD Anderson Cancer Center
2020-2024
Shenyang Pharmaceutical University
2024
Hangzhou First People's Hospital
2018-2023
Zhejiang University
2023
North University of China
2023
Shanxi Agricultural University
2023
The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. bieti, roxellana, and strykeri inhabit high-altitude habitats, whereas brelichi avunculus lowland regions. We report the de novo whole-genome sequence of R. bieti genomic sequences for four other species. Eight shared substitutions were found in six genes lung function, DNA repair, angiogenesis monkeys. Functional assays showed that variant CDT1...
Fruit tree leaves have different chemical compositions and diverse wax layer structures that result in patterns of wetting pesticide solution spreading on their surface. development is a time when pests diseases occur, during which large number pesticides are needed. The diffusion properties droplets fruit were relatively poor. To solve this problem, the characteristics leaf surfaces with surfactants studied. contact angle, surface tension, adhesive adhesion work, solid-liquid interfacial...
People celebrate the 100th anniversary of discovery human EEG from various perspectives and envision its promising future. In 1948, 20 years after EEG, first equipment was introduced in China. A long slow period development followed. The number papers China, about a year, represented 1/80 global total by 70th 1994. After steady rise, Chinese research reached 1/3 2024. Academic organizations related to were established during this process, along with widespread use thousands clinical...
Nickel phosphide catalysts supported on the TiO2–Al2O3 composite oxide were successfully prepared by impregnation of nickel phosphate precursors followed temperature-programmed reduction. The characterized X-ray diffraction, thermogravimetric analysis, IR spectroscopy, N2 adsorption, and photoelectron spectroscopy. catalytic activity was in a fixed-bed reactor for hydrodesulfurization using model liquid-feed dibenzothiophene, which contained 2000 mg/kg sulfur. Experimental results indicate...
Abstract Detection of de novo , low-frequency mutations is essential for characterizing cancer genomes and heterogeneous cell populations. However, the screening capacity current ultrasensitive NGS methods inadequate owing to either low-efficiency read utilization or severe amplification bias. Here, we present o2n-seq, an high-efficiency library preparation method discovering mutations. O2n-seq reduces error rate 10 −5 –10 −8 . The efficiency its data usage about 10–30 times higher than that...
Acute promyelocytic leukemia (APL) is a rare characterized by the balanced reciprocal translocation between gene on chromosome 15 and retinoic acid receptor α (RARα) 17, accounts for 10‑15% of newly diagnosed acute myeloid each year. The combined use all‑trans arsenic trioxide (ATO) as primary therapy has markedly improved survival rate patients with APL. Mortality in first 30 days following remains major contribution to treatment failure. In present study, published data was reviewed focus...
NGS (next generation sequencing) has been widely used in studies of biological processes, ranging from microbial evolution to cancer genomics. However, the error rate (0.1 % ~ 1 %) is still remaining a great challenge for comprehensively investigating low frequency variations, and current solution methods have suffered severe amplification bias or efficiency.We creatively developed Droplet-CirSeq relatively efficient, low-bias ultra-sensitive identification variations by combining millions...
Alzheimer's disease (AD) is the most common type of age‑related dementia, and causes progressive memory degradation, neuronal loss brain atrophy. The pathological hallmarks AD consist amyloid‑β (Aβ) plaque accumulation abnormal neurofibrillary tangles. Amyloid fibrils are constructed from Aβ peptides, which recognized to assemble into toxic oligomers exert cytotoxicity. fibrillar Aβ‑protein fragment 25‑35 (Aβ<sub>25‑35</sub>) induces local inflammation, thereby exacerbating apoptosis....
Abstract Next generation sequencing (NGS) technologies have dramatically improved studies in biology and biomedical science. However, no optimal NGS approach is available to conveniently analyze low frequency mutations caused by DNA damage treatments. Here, developing an exquisite ultra-sensitive (USNGS) platform “EasyMF” incorporating it with a widely used supF shuttle vector-based mutagenesis system, we can dissect roles of lesion bypass polymerases damage-induced mutagenesis. In this...
Abstract MicroRNAs (miRNAs) and short RNA fragments (18–25 nt) are crucial biomarkers in biological research disease diagnostics. However, their accurate rapid detection remains a challenge, largely due to low abundance, length, sequence similarities. In this study, we report on highly sensitive, one-step O-circle amplification (ROA) assay for miRNA detection. The ROA commences with the hybridization of circular probe test RNA, followed by linear rolling circle (RCA) using dUTP. This process...
Abstract Quinoa is a full‐nutrition food; however, its poor flavor and small size make it not the best food option for direct consumption. In this study, quinoa snack (QS, cake) was developed, aroma profile of products improved by adding jujube fruit powder (made from dried fruits, 5% to 30%). Gas chromatography mass spectrum (GC–MS) combined with electronic nose (e‐nose) applied characterizing profiles QS samples. Results showed total 26 compounds were identified in samples GC–MS,...
Understanding the impact of genetic alterations on epigenomic phenotypes during breast cancer progression is challenging with unimodal measurements. Here, we report wellDA-seq, first high-genomic resolution, high-throughput method that can simultaneously measure whole genome and chromatin accessibility profiles thousands single cells. Using profiled 22,123 cells from 2 normal 9 tumors tissues. By directly mapping to lineages across subclones, found evidence both hardwiring epigenetic...
Abstracts The genetic diversity within a single tumor can be extremely large, possibly with mutations at all coding sites (Ling et al. 2015). In this study, we analyzed 12 cases of multiple hepatocellular carcinoma (HCC) tumors by sequencing and genotyping several samples from each case. 10 cases, are clonally related process cell migration colonization. They permit detailed analysis the evolutionary forces (mutation, migration, drift natural selection) that influence both between tumors. 23...
The Amur tiger is a unique endangered species in the world, and thus, protection of its genetic resources extremely important.In this study, an placenta cDNA library was constructed using SMART Library Construction kit.A total 508 colonies were sequenced, which 205 (76%) genes annotated mapped to 74 KEGG pathways, including 29 metabolism, information processing, 4 environmental 7 cell motility, 5 organismal system pathways.Additionally, PLAC8, PEG10 IGF-II identified after screening from...