A5031034904- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- Nicotinic Acetylcholine Receptors Study
- Cancer, Stress, Anesthesia, and Immune Response
University Health Network
2019-2025
Princess Margaret Cancer Centre
2019-2025
Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the of lymphocyte-derived ACh viral infection is unknown. Here, we show that enzyme choline acetyltransferase (ChAT), which catalyzes rate-limiting step production, robustly induced both CD4+ and CD8+ cells during lymphocytic choriomeningitis virus (LCMV) IL-21-dependent manner. Deletion Chat within cell compartment mice...
Cholinergic nerves are involved in tumor progression and dissemination. In contrast to other visceral tissues, cholinergic innervation the hepatic parenchyma is poorly detected. It remains unclear whether there any form of regulation liver cancer. Here, we show that T cells curtail development cancer by supporting antitumor immune responses. a mouse multihit model hepatocellular carcinoma (HCC), observed activation adaptive response induction two populations CD4+ expressing choline...