A5005732843- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Invertebrate Immune Response Mechanisms
- Physiological and biochemical adaptations
- Chronic Myeloid Leukemia Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chronic Lymphocytic Leukemia Research
- Orthopaedic implants and arthroplasty
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Mycotoxins in Agriculture and Food
- Eosinophilic Disorders and Syndromes
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Coral and Marine Ecosystems Studies
- Acute Lymphoblastic Leukemia research
- Crystallography and molecular interactions
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
Ningbo University
2018-2025
Chinese Academy of Sciences
2025
Lanzhou Institute of Chemical Physics
2025
Nanjing Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2022-2024
Princess Margaret Cancer Centre
2015-2024
Chinese Academy of Fishery Sciences
2022-2024
Huazhong University of Science and Technology
2024
Nanjing Medical University
2023
Southern Medical University
2019-2022
The AACR Project GENIE is an international data-sharing consortium focused on generating evidence base for precision cancer medicine by integrating clinical-grade genomic data with clinical outcome tens of thousands patients treated at multiple institutions worldwide. In conjunction the first public release from approximately 19,000 samples, we describe goals, structure, and standards report conclusions high-level analysis initial phase data. We also provide examples utility data, such as...
The overall success rate of circumferential pulmonary vein isolation (CPVI) treatment in patients with paroxysmal atrial fibrillation (AF) remains suboptimal, especially older patients.
The RASopathies constitute a family of autosomal-dominant disorders whose major features include facial dysmorphism, cardiac defects, reduced postnatal growth, variable cognitive deficits, ectodermal and skeletal anomalies, susceptibility to certain malignancies. Noonan syndrome (NS), the commonest RASopathy, is genetically heterogeneous caused by functional dysregulation signal transducers regulatory proteins with roles in RAS/extracellular signal-regulated kinase (ERK) transduction...
Abstract Increasing evidence confirms that exosome‐mediated transfer of microRNAs can influence cancer progression including tumor cell invasion, proliferation, and drug resistance via cell–cell communication. However, the potential role exosomal‐miR‐1260b in lung adenocarcinoma (LAC) remains poorly understood. Thus, this study focused on investigating function invasion. Exosomal‐miR‐1260b was found to be higher plasma patients with LAC than healthy persons quantitative real‐time polymerase...
Deployment of coronary stents to relieve atherosclerotic obstruction has benefitted millions patients. However, gene therapy prevent in-stent restenosis, while promising in experimental studies, remains a challenge. Conventional strategies for viral vector administration utilize catheters that deliver infusions suspensions, which result suboptimal localization and potentially dangerous distal spread vector. Stent-based delivery may circumvent this problem. We hypothesized site-specific...
BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common worldwide. Circular RNAs (circRNAs) are recently identified as important gene regulators with critical roles in biology. In this study, we focus on effect of circ_0000376 targeting miR-384 malignant phenotypes NSCLC cells. METHODS: Circ_0000376 and expression tissue samples were measured using qRT-PCR. The association between pathological parameters was analyzed well. Human lines A549 NCI-H460 used models. CCK-8 BrdU assay to...
Selective breeding for DIV1-resistant Macrobrachium rosenbergii is an effective strategy to mitigate aquaculture losses; however, the underlying resistance mechanisms remain poorly understood. In this study, approximately 2,300 prawns from 46 families were subjected a DIV1 challenge test. Based on survival rate, viral load, histopathological observations, and gene detection in transcriptome, one resistant family (R27-1) susceptible (S2-2) identified. Hepatopancreas transcriptomic (RNA-Seq)...
Fumonisin B1 (FB1) was reacted with fructose in an attempt to detoxify this mycotoxin. Fischer 344/N rats were initiated diethylnitrosamine (15 mg/kg body weight) and then fed 69.3 μmol FB1/kg diet or FB1 (FB1−fructose)/kg for 4 weeks. In comparison the basal FB1−fructose, FB1-fed had significantly increased plasma cholesterol (P < 0.01), alanine aminotransferase activity 0.05), endogenous hepatic prostaglandin production 0.05). Placental glutathione S-transferase-positive γ-glutamyl...
Abstract Effective removal of the fatty acid matrix and enrichment trace target components is a key step in quantitative analysis minor edible oils. In this study, novel sample pretreatment method named freezing crystallization was developed to analyze pigments extra virgin olive oil (EVOO). The limits detection quantification were 0.125–0.625 μg/mL 0.5–2.5 μg/mL, respectively. Linear correlations obtained (r 2 ≥ 0.9995), recoveries at three spiked levels 84.2%–105.8%. Besides, primary...
The farming of Macrobrachium rosenbergii faces significant challenges due to infections caused by Decapod iridovirus 1 (DIV1). To gain deeper insights into the dynamic immune regulatory processes M. in response DIV1 infection, RNA sequencing (RNA-seq) was employed profile transcriptome hepatopancreas at 24, 48, 72, and 96 hours post-infection (hpi). Time-course analysis revealed 3,339 differentially expressed genes (DEGs), which exhibited distinct expression patterns across various stages...
We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics linked biomedical data. CanDIG leverages standards frameworks Global Alliance Health (GA4GH) currently hosts data five pan-Canadian projects. describe CanDIG's key design decisions features as a guide other systems.
Abstract Objective: Calcification of polyurethane prosthetic valve leaflets causes a major functional impairment. Previously we showed that heart valves modified with covalently linked bisphosphonate groups were resistant to calcification in vivo . However, also found the highly polar anionic on surface attracted sodium counter ion adsorption, and thereby increased elastomer's water absorption 20% total weight. In this study address by investigating hypothesis attaching cationic diethylamino...
Abstract Leukemia stem cells (LSCs) are linked to relapse in acute myeloid leukemia (AML). The LSC17 gene expression score robustly captures LSC stemness properties AML and can be used predict survival outcomes response therapy, enabling risk-adapted, upfront treatment approaches. was developed validated a research setting. To enable widespread use of the clinical decision making, we established laboratory-developed test (LDT) for that deployed broadly molecular diagnostic laboratories. We...