A5101667759- Circular RNAs in diseases
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Botanical Studies and Applications
- Botany, Ecology, and Taxonomy Studies
- Protein Kinase Regulation and GTPase Signaling
- Traditional Chinese Medicine Analysis
- Plant tissue culture and regeneration
- Drug-Induced Hepatotoxicity and Protection
- Hybrid Renewable Energy Systems
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reconstructive Facial Surgery Techniques
- Seed Germination and Physiology
- Advanced Cellulose Research Studies
- Immune Response and Inflammation
- Zebrafish Biomedical Research Applications
- Genetics and Neurodevelopmental Disorders
- Plant Genetic and Mutation Studies
- Angiogenesis and VEGF in Cancer
- Bone and Joint Diseases
- Ion Transport and Channel Regulation
- 14-3-3 protein interactions
Zhejiang Sci-Tech University
2007-2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Hubei University
2022-2024
Fujian Medical University
2023
Second Affiliated Hospital of Fujian Medical University
2023
Beijing Tongren Hospital
2022
Capital Medical University
2012-2022
Zhangjiagang First People's Hospital
2021
Soochow University
2021
Signal transducer and activator of transcription 3 (STAT3) is involved in the growth metastasis breast cancer, represents a potential target for developing new anti-tumor drugs. The purpose this study to investigate whether Lycorine, pyrrolo[de]phenanthridine ring-type alkaloid extracted from Amaryllidaceae genera, could inhibit cancer by targeting STAT3 signaling pathway. human cell lines were incubated with various concentrations proliferation, colony formation, cycle distribution,...
MicroRNAs (miRNAs) are widely expressed in human cells and closely associated with various types of cancer, including breast cancer. miR-876-5p has been indicated to participate the tumorigenesis certain such as hepatocellular carcinoma. Nevertheless, roles cancer remain unclear. In present study, it was revealed that expression levels were decreased compared a normal cell line. ectopic suppressed proliferation arrested progression cycle. addition, migration invasion. demonstrated directly...
ErbB4, a type I transmembrane receptor tyrosine kinase, is member of the epidermal growth factor family. Its cleavage releases an intracellular C-terminal domain (ICD), which can be either degraded following ubiqitination or translocated to nucleus and regulate gene expression. There are 2 ErbB4 ICD isoforms: CYT-1 CYT-2. We others have previously reported that cleavage, CYT-2 selectively translocates nucleus. In current study we found levels decreased rapidly, while remained relatively...
Background/Aim: P21, a multifunctional cell cycle-regulatory molecule, regulates apoptotic death. In this study we examined the effect of altered p21 expression on sensitivity acute myeloid leukemia cells in response to HDAC inhibitor SAHA treatment and investigated underlying mechanism. Methods: Stably transfected HL60 lines were established RPMI-1640 with supplementation G-418. Cell viability was measured by MTT assay. Western blot applied assess protein levels target genes. apoptosis...
The purpose of this study is to use Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide (DCP) act on the NF-κB inflammatory pathway and Fas/FasL ligand system, in order find a new method improve immune liver injury. Lipopolysaccharide (LPS) was used establish an injury model vivo (Kunming mice) vitro (LO2 cells). In experiment, hematoxylin-eosin (H&E) staining related biochemical indicators were observe pathological changes tissues, oxidative stress reactions. Immunohistochemistry,...
Abstract Background The completion and reporting of baculovirus genomes is extremely important as it advances our understanding gene function evolution. Due to the large number viral now sequenced very that authors present significantly detailed analyses advance genomes. However, there no report Antheraea pernyi nucleopolyhedrovirus (AnpeNPV) genome. Results genome AnpeNPV, which infects Chinese tussah silkworm ( ), was analyzed. 126,629 bp in size. G+C content genome, 53.4%, higher than...
This research aimed to explore the molecular mechanism of microRNA (miR)-106b in cell apoptosis atherosclerosis (AS). Human aortic endothelial cells (HAECs) were divided into control group, oxidized-low-density lipoproteins (ox-LDL) miR-106b NC+ox-LDL mimics+ox-LDL mimics+PTEN+ox-LDL and mimics+empty+ox-LDL group. Real-time fluorescence quantitative polymerase chain reaction, cholecystokinin, TdT-mediated biotinylated nick end-labeling assay, luciferase reporter gene flow cytometry analysis...
In multiple malignant tumors, circular RNAs (circRNAs) are believed to play a crucial role. Our prior results demonstrated that circ_ZNF778_006 was significantly increased in esophageal squamous cell carcinoma (ESCC) tissues, but the roles of ESCC is still not clear. The expression compared different pathological grades ESCC. And levels circ_ZNF778_006, miR-18b-5p, HIF-1α were analyzed by qRT-PCR and Western blot, respectively. Plasmid transfection techniques applied prepare cells with...
Emerging documents revealed that E2 enzyme family has been implicated in regulating the progression of numerous human cancers. Ubiquitin-conjugating J1 (UBE2J1), a member family, reported to participate biological process medulloblastoma, while little is known about its functionality endometrial cancer (EC). Gene expression at mRNA and protein levels were identified using RT-qPCR western blot analysis, separately. The alteration on cell proliferation, adhesion, migration, invasion,...
Deinanthe caerulea is a rare perennial herb endemic to China that has high medicinal and ornamental value. Seeds of D. are tiny with thousand seed weight only 200 mg. Thus, classical germination tests difficult apply in this species rapid accurate method for determining viability becomes an important prerequisite conservation, introduction domestication. When using the tetrazolium (TTC) topographical staining method, removing coat TTC penetration not practical. Therefore, experiment, we...
Introduction:The aim of the study was to investigate effects metformin and sitagliptin on glycolipid metabolism in type 2 diabetes after different diets.Material methods: Seventy Male Sprague Dawley rats were fed with a high fat diet followed by streptozotocin treatment induce diabetes.Then all randomly divided into control group, group (200 mg/kg), (10 mg/kg).Each further 4 groups receiving one load carbohydrate (45% glucose, 4.5 ml/kg), (20% lipid emulsion, protein whey protein, 10 ml/kg)...
High-performance eco-friendly soft actuators showing large displacement, fast response, and long-term operational capability require further development for next-generation bioinspired robots. Herein, we report an electro-ionic actuator based on carboxylated cellulose nanocrystals (CCNC) nanofibers (CCNF), graphene nanoplatelets (GN), ionic liquid (IL). The exhibited exceptional actuation performances, achieving displacements ranging from 1.6 to 12.3 mm under ultralow voltages of 0.25–1.5 V....
Deinanthe caerulea is a rare plant endemic to China and narrowly restricted species native only Hubei Province. It endangered in the Chinese Red List (CSRL) at VU level. To date, research on it has been extremely limited. In this paper, SSR molecular marker technology was used study genetic diversity level structure of six existing populations. A total 178 Stapf. samples from populations were amplified by PCR using selected 10 pairs primers. The results showed following: (1) Based Nei’s...
Deinanthe caerulea Stapf. is a rare and endangered plant endemic to China of important medicinal value. In this paper, SSR molecular marker technology was used study the genetic diversity level structure six existing populations. A total 178 samples from populations were amplified by PCR using selected 10 pairs primers. The results showed following: (1) Based on Nei’s distance, UPGMA method construct relationship clustering map each population. (2) Stapf low, Shannon's index Nei's gene...