A5049818444- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Fuel Cells and Related Materials
- Organ Transplantation Techniques and Outcomes
- Anesthesia and Neurotoxicity Research
- Ion channel regulation and function
- Advanced MRI Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Adipose Tissue and Metabolism
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
Cedars-Sinai Smidt Heart Institute
2016-2024
Cedars-Sinai Medical Center
2014-2024
Wayne State University
2006-2015
Fleet Science Center
2014
San Diego State University
2009-2013
American College of Surgeons
2000-2013
Cardiovascular Institute Hospital
2011-2012
National Heart Lung and Blood Institute
1990-2011
Good Samaritan Regional Medical Center
2011
Good Samaritan Medical Center
2011
Background. After heart transplantation, 1-year and 5-year survival rates are 79% 63%, respectively, with rejection, infection, allograft coronary artery disease accounting for the majority of deaths. Mycophenolate mofetil (MMF), an inhibitor de novo pathway purine biosynthesis, decreases rejection in animals human renal transplantation. Methods. In a double-blind, active-controlled trial, 28 centers randomized 650 patients undergoing their first transplant to receive MMF (3000 mg/day) or...
In Brief Background: The Veterans Affairs ’ (VA) National Surgical Quality Improvement Program (NSQIP) has been associated with significant reductions in postoperative morbidity and mortality. We sought to determine if NSQIP methods risk models were applicable private sector (PS) hospitals implementation of the PS would be adverse outcomes. Methods: Data from patients (n = 184,843) undergoing major general or vascular surgery between October 1, 2001, September 30, 2004, 128 VA 14 academic...
Objective To assess the feasibility of implementing National Surgical Quality Improvement Program (NSQIP) methodology in non-VA hospitals. Summary Background Data Using data adjusted for patient preoperative risk, NSQIP compares performance all VA hospitals performing major surgery and anonymously these using ratio observed to expected adverse events. These results are provided each hospital used identify areas improvement. Since NSQIP's inception 1994, has reported consistent improvements...
In Brief Objective: The purpose of this study was to determine the relationship between American Society Anesthesiologists' Physical Status (ASA PS) classifications and other National Surgical Quality Improvement Program (NSQIP) preoperative risk factors. Background: ASA PS has been shown predict morbidity mortality in surgical patients but is inconsistently applied clinically imprecise. It desirable have a method for validating classification levels. Methods: NSQIP factors, including PS,...
Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD. Although a large number novel have been discovered research laboratory, their translation setting has largely disappointing. The reason for this failure can be attributed factors including inadequacy animal ischemia-reperfusion injury models used preclinical cardioprotection studies and inappropriate design execution...
To examine the role of alterations in myofibrillar function human dilated cardiomyopathies, we determined isometric tension-calcium relations permeabilized myocytesized preparations (n = 16) obtained from left ventricular biopsies nine patients with cardiomyopathy (DCM) during cardiac transplantation or assist device implantation. Similar 10) were six normal hearts used for transplantation. Passive and maximal Ca2+-activated tensions similar two groups. However, calcium sensitivity tension...
To evaluate the University of Kentucky experience in treating acute intestinal ischemia to elucidate factors that contribute survival.Acute is reported have a poor prognosis, with survival rates ranging from 0% 40%. This based on several reports, most which were published more than decade ago. Remarkably, there paucity recent studies report current outcome for mesenteric ischemia.A comparative retrospective analysis was performed patients who diagnosed between May 1993 and July 2000....
This single-center study tested the hypothesis that preoperative risk factors and surgical complexity predict more variation in hospital costs than complications.Complications after operations have been shown to significantly increase cost. The impact on complication-related of is less well known.The National Surgical Quality Improvement Program (NSQIP) factors, complexity, outcomes, along with costs, were analyzed for a random sample 5875 patients 6 services. Operation was assessed by work...
Based on growing evidence linking autophagy to preconditioning, we tested the hypothesis that is necessary for cardioprotection conferred by ischemic preconditioning (IPC). We induced IPC with three cycles of 5 min regional ischemia alternating reperfusion and assessed induction in mCherry-LC3 transgenic mice imaging fluorescent autophagosomes cryosections. found a rapid significant increase number risk zone preconditioned hearts. In Langendorff-perfused hearts subjected an protocol 3 x...
Emerging evidence suggests that "adaptive" induction of autophagy (the cellular process responsible for the degradation and recycling proteins organelles) may confer a cardioprotective phenotype represent novel strategy to limit ischemia-reperfusion injury. Our aim was test this paradigm in clinically relevant, large animal model acute myocardial infarction.Anesthetized pigs underwent 45 minutes coronary artery occlusion 3 hours reperfusion. In first component study, received chloramphenicol...
The purpose of this study was twofold: 1) to investigate the feasibility and usefulness cardiac microdialysis for simultaneous estimation regional interstitial fluid (ISF) adenosine (ADO) concentration coronary blood flow (CBF); 2) determine changes in ISF levels ADO CBF during stimulation or myocardial ischemia. Cardiac probes were implanted left ventricular myocardium chloralose-urethan-anesthetized dogs perfused with Krebs-Henseleit buffer. effluent dialysate used as an index...