A5047993836- Mass Spectrometry Techniques and Applications
- X-ray Diffraction in Crystallography
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Bioactive Natural Diterpenoids Research
- Eating Disorders and Behaviors
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Hungarian Social, Economic and Educational Studies
- Chemical Synthesis and Analysis
- Magnetic properties of thin films
- Nanoparticle-Based Drug Delivery
- Magnetic Properties of Alloys
- Plant-based Medicinal Research
- Ion-surface interactions and analysis
- Nuclear Physics and Applications
- DNA Repair Mechanisms
- Advanced Chemical Physics Studies
- Hormonal and reproductive studies
- Catalytic Processes in Materials Science
- Cancer, Hypoxia, and Metabolism
- Plasma Applications and Diagnostics
- Catalytic Cross-Coupling Reactions
- Biological Activity of Diterpenoids and Biflavonoids
HUN-REN Research Centre for Natural Sciences
2016-2025
Research Network (United States)
2021-2025
Szent János Kórház
2018-2024
Semmelweis University
2021-2024
Hungarian Research Network
2023-2024
Czech Academy of Sciences, Institute of Botany
2024
Masaryk University
2024
University of Debrecen
1982-2022
ORCID
2022
V. B. Sochava Institute of Geography
2022
The magnetic structures and transformations in the ordered phases of Mn-Pt system have been investigated a wide concentration range by magnetic, x-ray, neutron diffraction methods. properties ${\mathrm{Mn}}_{3}{\mathrm{Pt}}_{1\ensuremath{-}y}{\mathrm{Rh}}_{y}$ ${\mathrm{Mn}}_{3\ensuremath{-}z}{\mathrm{Fe}}_{z}\mathrm{Pt}$ systems also studied. triangular collinear antiferromagnetic structures, both found ${\mathrm{Mn}}_{3}$Pt phase, undergo first-order transformation into each other at...
Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in balancing excitatory inhibitory signals the brain. Increasing evidence suggest that they may act concertedly to regulate extracellular levels of neurotransmitters.Here we present glutamate uptake-induced release GABA from astrocytes has a direct impact on excitability pyramidal neurons hippocampus. We demonstrate GABA, synthesized polyamine putrescine, is released by reverse action glial transporter (GAT) subtypes...
Investigations of the magnetic properties in ordered CuAu-I-type manganese alloys are reviewed. The formation phase and possible structures discussed. New experimental results for Mn-Ni, Mn-Pd, Mn-Pt systems reported. Neutron diffraction shows basic antiferromagnetic structure to be same all investigated. In MnPt a magnetic-structure transformation has been observed. Below 800°K moments turn from basal plane gradually tetragonal axis. variation transition temperature system as well that Néel...
Therapy resistance has long been considered to occur through the selection of pre-existing clones equipped survive and quickly regrow, or acquisition mutations during chemotherapy. Here we show that following in vitro treatment by chemotherapy, epithelial breast cancer cells adopt a transient drug tolerant phenotype characterized cell cycle arrest, epithelial-to-mesenchymal transition (EMT) reversible upregulation multidrug (MDR) efflux transporter P-glycoprotein (P-gp). The persister (DTP)...
The effects of 15 jatrophane diterpene polyesters (1−3 and 5−16) isolated from lipophilic extracts Euphorbia serrulata, E. esula, salicifolia, peplus (Euphorbiaceae) on the reversion multidrug resistance mouse lymphoma cells were examined. structures five new compounds (1−5) elucidated by spectroscopic methods, including HRFABMS, ESIMS, 1H−1H homonuclear 1H−13C heteronuclear correlations, long-range correlation spectra, NOESY experiments. stereochemistry absolute configuration one compound...
Baicalein, the aglycone formed by hydrolysis of baicalin in intestine, is well absorbed passive diffusion but subjected to extensive intestinal glucuronidation. Efflux baicalin, low permeability glucuronide baicalein from enterocytes, likely depends on a carrier-mediated transport. The present study was designed explore potential drug-herb interaction investigating inhibitory effect transport reporter substrates transporters and identify responsible for efflux enterocytes hepatocytes. with...
Accumulating evidence indicate that astrocytes are essential players of the excitatory and inhibitory signaling during normal epileptiform activity via uptake release gliotransmitters, ions, other substances. Polyamines can be regarded as gliotransmitters since they almost exclusively stored in released by various mechanisms. The polyamine putrescine (PUT) is utilized to synthesize GABA, which also from provide tonic inhibition on neurons. spermine (SPM), synthesized form PUT through...
Historical ecology draws on a broad range of information sources and methods to provide insight into ecological social change, especially over the past ∼12000 yr. While its results are often relevant conservation restoration, insights from diverse disciplines, environments, geographies have frequently remained siloed or underrepresented, restricting their full potential. Here, scholars practitioners working in marine, freshwater, terrestrial environments 6 continents various archipelagoes...
Pseudoxanthoma elasticum (PXE) is a heritable disease characterized by calcified elastic fibers in cutaneous, ocular, and vascular tissues. PXE caused mutations ABCC6, which encodes protein of the ATP-driven organic anion transporter family. The inability this to secrete its substrate into circulation likely cause PXE. Vitamin K plays role regulation mineralization processes as co-factor carboxylation calcification inhibitors such Matrix Gla Protein (MGP). precursor or conjugated form has...
Recent studies demonstrated that cytosine methylation in the genome can be reversed without DNA replication by enzymatic mechanisms based on base excision-repair pathways. Both and demethylation are active cell nucleus at same time. One hypothesize actual level of CpG could result a balance between two antagonistic processes with rapid turnover. In present study, we used mass spectrometry to measure total methyl-cytosine content cultured human cells after short incubation known...
The effect of composition on the first-order transformation from triangular into collinear antiferromagnetic structure (AF-AF transformation) occurring in ordered Mn3Pt has been investigated ternary Mn3Pt1−xRhx and binary Mn3+yPt1−y alloys using x-ray neutron-diffraction methods. On increasing concentrations x y an increase both Néel transition temperatures with a simultaneous decrease lattice parameter were observed. magnetic moment Mn remained same irrespective concentration AF-AF...
The antiproliferative effects of n-hexane, chloroform and aqueous methanol extracts prepared from the whole plant Centaurea arenaria M.B. ex Willd. were investigated against cervix adenocarcinoma (HeLa), breast (MCF7) skin epidermoid carcinoma (A431) cells, using MTT assay. extract displayed high tumour cell proliferation inhibitory activity (higher than 85% at 10 μg/mL concentration), was therefore subjected to a bioassay-guided multistep separation procedure. Flavonoids (eupatilin,...