A5082403005- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Neonatal and Maternal Infections
- Liver Disease and Transplantation
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Infant Development and Preterm Care
- Ultrasound in Clinical Applications
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Blood groups and transfusion
- Acute Ischemic Stroke Management
- Sepsis Diagnosis and Treatment
- Urinary Tract Infections Management
- Respiratory viral infections research
- Global Maternal and Child Health
- Traumatic Ocular and Foreign Body Injuries
- Diabetes and associated disorders
- Ocular Infections and Treatments
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Trauma and Emergency Care Studies
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
Patan Academy of Health Sciences
2016-2025
University of California, Riverside
2025
Bir Hospital
2024
National Academy of Medical Sciences
2024
Kanchi Kamakoti CHILDS Trust Hospital
2021-2022
Patan Hospital
2014-2021
B.P. Koirala Institute of Health Sciences
2013
Manipal College of Medical Sciences
2013
ABSTRACT NDM-producing Klebsiella pneumoniae strains represent major clinical and infection control challenges, particularly in resource-limited settings with high rates of antimicrobial resistance. Determining whether transmission occurs at a gene, plasmid, or bacterial strain level within hospital and/or the community has implications for monitoring controlling spread. Whole-genome sequencing (WGS) is highest-resolution typing method available epidemiology. We sequenced...
Abstract Background Sepsis is an overwhelming and life-threatening response to bacteria in bloodstream a major cause of neonatal morbidity mortality. Understanding the etiology potential risk factors for sepsis urgently required, particularly low-income countries where burden infection high its epidemiology poorly understood. Methods A prospective observational cohort study was conducted between April 2016 October 2017 level three NICU at tertiary care hospital Nepal determine bacterial...
Introduction: Stroke is characterized as a sudden occurrence of neurologicdeficit caused by focal vascular reason. classified into two types:Hemorrhagic and Ischemic. The ABO blood groups can impact thrombosis byhaving elevated levels VWF factor VIIIc (possibly affected an O(H)antigen-related change in metabolism), along with increased acquiredresistance to activated protein C observed individuals without typeO. objective this research identify possible connection betweenABO group ischemic...
Pediatric acute liver failure is a rare and serious disease. Though transplantation considered as the established treatment option for patients who are unlikely to recover with medical management, however, advancement of care there has been an increase in spontaneous regeneration liver, obviating need transplantation. We identified etiologies, outcome prognostic factors validity existing criteria predict pediatric failure.This was retrospective study done from January 2014 December 2019...
In Nepal, Streptococcus pneumoniae (pneumococcus) is a common cause of bacterial pneumonia in children, and major health concern. There are few data on the effect vaccination disease or colonisation with pneumococci nasopharynx children this setting. The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced into routine infant immunisation schedule Nepal 2015. We aimed to investigate introduction PCV10 carriage Nepal.We did an observational cohort study Nepal. hospital surveillance...
Enterobacter kobei is an emerging cause of outbreak nosocomial infections in neonatal intensive care units (NICUs). Between July and September 2016, a NICU tertiary hospital Nepal observed abrupt increase the number sepsis cases caused by spp. infecting 11 out 23 admitted neonates, five whom died exacerbated sepsis.To confirm suspected outbreak, identify environmental source infection, characterize genetic determinants antimicrobial resistance (AMR) virulence pathogen.Whole-genome sequencing...
Background: Ocular injury is one of the major causes monocular visual impairment and blindness worldwide, with significant socioeconomic impact. The present study was done to establish incidence identify common ocular trauma in a tertiary care hospital western Nepal. Methods: This cross-sectional study, conducted at teaching Nepal from January 2012 2013. All cases attending emergency eye OPD were included study. A complete history detailed ophthalmological evaluation done. Results: Total...
Introduction: Kawasaki disease is an acute vasculitis of unknown etiology. The epidemiological data available for Nepal remains insufficient. In Nepal, has only been reported in cases brief reports, leaving the true burden unknown. Many go undiagnosed and untreated due to a lack knowledge regarding this entity. objective study was find prevalence tertiary care hospital.
 Methods: This descriptive cross-sectional carried out hospital from 2013 2018 after taking ethical approval...
Introductions: Perinatal mortality rate (PMR) of Nepal is 31 deaths per 1000 pregnancies and neonatal (NMR) 21 live births according to Demographic Health Survey (NDHS) 2016. This study aims analyse the trend PMR NMR babies delivered at Patan hospital, Nepal. 
 Methods: was a retrospective done in department Pediatrics perinatal outcome during three years from April 2016 March 2019 Hospital, Academy Sciences, Data collected hospital records audit. The mode delivery (vaginal,...
Introductions: Klebsiella sepsis is the most important nosocomial infection in neonates. The objectives of this study were to review an outbreak a neonatal unit caused by species, identify source infections, and control measures for eradication prevention these infections. Methods: case notes investigation reports all cases admitted units Patan hospital from July December 2011 species retrospectively reviewed. demographic profile, risk factors along with clinical features management Results:...
Introduction: Urinary tract infection is one of the most common infections in children. Antibiotics are usually given empirically before urine culture reports available. The primary aim this study was to see causative organisms and sensitivity pattern urinary hospitalized children.Material Methods: All children aged 0-15 years with positive who were admitted children’s ward from 14th April 2013 2014 included. for along its antibiotic retrospectively reviewed analyzed.Results: 48 cases...
Hand hygiene has been identified as the single most important factor in minimising hospital acquired infections. However, compliance of handwashing guidelines remained low. The aim this study was to practices Paediatric and Neonatal intensive care units nurseries Patan Hospital, secondly re-evaluate improvement on after intervention.Pre-intervention conducted by covertly observing healthcare workers. workers were then shown video demonstrating correct methods recommended World health...
We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for infection in children with pneumonia Nepal. Children did not have higher convalescent, or fold change, than other causes pneumonia. Caution needed interpreting antibody responses infections.
Introduction: COVID-19 is a disease caused by novel coronavirus SARS-CoV-2 that led to global epidemic resulting in significant morbidity across all ages. This study intended find out the clinical presentation of children and compare them among different age categories children. Method: retrospective done over period one year COVID facility Patan hospital. Demographic profile who were tested positive polymerase chain reaction (PCR) recorded. The data was compiled Microsoft Excel 2021...
Systemic lupus erythematosus (SLE) and Wilson's disease (WD) can present similar symptoms, complicating diagnosis.This case report details a rare instance of both conditions in 12-year-old girl, emphasizing the diagnostic challenges.It highlights need to explore possibility concurrent WD patients diagnosed with SLE.
Introduction: Echocardiography is an indispensable tool for the diagnosis and management of cardiac patients. It important to know spectrum abnormalities detected by echocardiography proper The aim this study was evaluate echocardiographic patients at a multispecialty tertiary care hospital find out prevalence various diseases diagnosed via echocardiography.Methods: This retrospective cross sectional carried lab National Academy Health Sciences. Records all who had done from February 2024...
Introduction: Stroke is characterized as a sudden occurrence of neurologic deficiency caused by focal vascular reason. classified into two types: Hemorrhagic and Ischemic. The ABO blood groups can impact thrombosis having elevated levels VWF factor VIIIc (possibly affected an O(H) antigen-related change in metabolism), along with increased acquired resistance to activated protein C observed individuals without type O. objective this research identify possible connection between group...
Diabetes mellitus is a disease of abnormal carbohydrate metabolism that are characterized by hyperglycemia which associated with relative or absolute impairment in insulin secretion, along varying degrees peripheral resistance to the action insulin. Type-2 diabetes (T2DM), responsible for significant morbidity and mortality continued scientific research. This study evaluated any association between ABO-RH blood groups among T2DM healthy individuals. A hospital-based comparative...