A5048245326- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Advanced Sensor and Energy Harvesting Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- Molecular Junctions and Nanostructures
- Nanowire Synthesis and Applications
- Analytical Chemistry and Sensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Surface Modification and Superhydrophobicity
- Plasmonic and Surface Plasmon Research
- 3D Printing in Biomedical Research
- Electrochemical sensors and biosensors
- Semiconductor materials and devices
- Gas Sensing Nanomaterials and Sensors
- Advancements in Semiconductor Devices and Circuit Design
- Electrochemical Analysis and Applications
- Advanced Chemical Sensor Technologies
- Reproductive Biology and Fertility
- Neuroscience and Neural Engineering
- Methane Hydrates and Related Phenomena
- Sperm and Testicular Function
- Pneumonia and Respiratory Infections
- Hemoglobin structure and function
National Yang Ming Chiao Tung University
2014-2025
National Hsinchu University of Education
2019-2020
National Taiwan University
2011-2013
Institute of Atomic and Molecular Sciences, Academia Sinica
2011-2013
Academia Sinica
2013
University of Edinburgh
2006-2008
University of Manchester
2006
Institute of Structural and Molecular Biology
2006
Institute of Biomedical Sciences, Academia Sinica
2004
Dopamine (DA) is an important neurotransmitter that involved in neuronal signal transduction and several critical illnesses. However, the concentration of DA extremely low patients difficult to detect using existing electrochemical biosensors with detection limits typically around nanomolar levels (∼10(-9) M). Here, we developed a nanoelectronic device as biosensor for ultrasensitive selective by modifying DNA-aptamers on multiple-parallel-connected (MPC) silicon nanowire field-effect...
Recent advances in microelectronics and electrochemical sensing platforms have preceded the development of devices for personal monitoring managing physiological metabolic information that exploit sweat as a noninvasive, convenient approach providing about underlying health conditions, such glucose level monitoring. Although most sensors targeted applications during exercise other active stimulation induced-sweat, natural sweating offers an attractive alternative with minimal effect on users...
Abstract High‐performance deep ultraviolet (DUV) spectroscopy is crucial in driving innovations for biomedical research, clinical diagnosis, and material science. DUV resonant nanostructures have shown capabilities significantly improving sensitivity. However, they encounter significant challenges practical applications, including instability due to oxidation light‐induced damage, the strong photoluminescent noise background from their constituent materials. An efficient robust platform...
Diabetes has become a chronic metabolic disorder, and the growing diabetes population makes medical care more important. We investigated using portable noninvasive contact lens as an ideal sensor for patients whose tear fluid contains glucose. The key feature is reversible covalent interaction between boronic acid glucose, which can provide glucose patients. present phenylboronic (PBA)-based HEMA that exhibits swelling/shrinking effect to change its thickness. difference in thickness be...
We have previously identified a new centrosomal protein, protein 4.1-associated (CPAP), which is associated with the gamma-tubulin complex. Here, we report that CPAP carries novel microtubule-destabilizing motif not only inhibits microtubule nucleation from centrosome but also depolymerizes taxol-stabilized microtubules. Deletion mapping and functional analyses defined 112-residue necessary sufficient for destabilization. This directly recognizes plus end of centrosome. Biochemical revealed...
Biofouling due to nonspecific proteins or cells on the material surfaces is a major challenge in range of applications such as biosensors, medical devices, and implants. Even though poly(ethylene glycol) (PEG) has become most widely used stealth pharmaceutical products, number reported cases PEG-triggered rare allergic responses continues increase past decades. Herein, new type antifouling poly(amine oxide) (PAO) been evaluated an alternative overcome foulant adsorption impart comparable...
Abstract Peripheral blood lymphocytes (PBLs) are mature that circulate in the rather than being localized to organs. A reliable label-free collection approach can viably and appropriately isolate PBLs establish vitro culture systems is crucial for basic research clinical requirements. However, isolation of from whole difficult, so development a rapid safe method perform this task required. Microfluidic technology offers opportunities challenge performance macroscale methods. In study, we...
Lung cancer is one of the leading causes death worldwide.
Assisted reproductive technology (ART) is an important invention for the treatment of human infertility, and isolation high-quality sperm with progressive motility one most critical steps that eventually affect fertilization rate. Conventional separation approaches include swim-up method density gradient centrifugation. However, quality isolated obtained from both can still be improved by improving sorted motility, minimizing DNA fragmentation rate, removing abnormal phenotypes. Here, we...
Abstract Since nucleic acid amplification technology has become a vital tool for disease diagnosis, the development of precise applied detection technologies in point-of care testing (POCT) more significant. The microfluidic-based platform offers great opportunity on-site diagnosis efficiency, and system is aimed at user-friendly access. Herein, we demonstrate microfluidic with simple operation that provides reliable results from 18 uniform droplets via LAMP detection. By using only...
During the COVID-19 pandemic, use of lateral flow assays (LFAs) expanded significantly, offering testing beyond traditional health care. Their appeal lies in ease use, affordability, and quick results. However, LFAs often have lower sensitivity specificity compared with ELISA PCR tests. Efforts to improve increased detection times complexity, limiting their large-scale point-of-care settings. To address this, we propose a novel approach using probes that generate multiple signals enhance...
High-performance DUV spectroscopy drives advancements in biomedical research, clinical diagnosis, and material science. Existing resonant nanostructures face instability photoluminescent noise challenges. We propose robust Si metasurfaces leveraging polaritonic resonances, a unique property driven by interband transitions, for enhanced nanophotonic sensing. Our Kerker-type void metasurface enables double-resonance Raman scattering to analyze 2D semiconductors, improves biomolecule...
Open-surface microfluidics is promising in terms of enabling economical and rapid biochemical analysis for addressing challenges associated with medical diagnosis food safety. To this end, we present a simple approach to develop an open-surface microfluidic platform suitable facile liquid transport mixing. Customizable patterns tailored wettability are deposited using plasma-assisted deposition technique under atmospheric pressure. The flow the dispensed driven by gravity, tilting angle...
Blood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood is interference red cells; however, conventional methods separation are often complicated time consuming. In this study, we devised a simple but high-efficiency system on self-strained microfluidic device separates 99.7 ± 0.3% plasma in only 6 min. Parameters, such as flow rate, design filter trench, relative positions trench channel, were optimized...