A5034429046- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Hemodynamic Monitoring and Therapy
- Enhanced Recovery After Surgery
- Treatment of Major Depression
- Medical History and Innovations
- Music Therapy and Health
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Tracheal and airway disorders
- Acupuncture Treatment Research Studies
- Respiratory Support and Mechanisms
- Pain Management and Treatment
- Epilepsy research and treatment
- Dental Anxiety and Anesthesia Techniques
- Laser Applications in Dentistry and Medicine
Naval Surface Warfare Center
2023-2025
The Mountain Institute
2015-2024
Cedars-Sinai Medical Center
2015-2024
University of the West of England
2024
University of Sheffield
2022
Radboud University Nijmegen
2022
Cambridge University Hospitals NHS Foundation Trust
2021
Anglia Ruskin University
2021
Imperial College London
2021
University of Michigan
2019-2021
Ketamine—Its Pharmacology and Therapeutic Uses Paul white;Walter Way;anthony Trevor; Anesthesiology
The use of the intravenous anesthetic etomidate for prolonged sedation has been associated with low levels plasma cortisol and increased mortality. We measured aldosterone responses to ACTH stimulation in five patients receiving etomidate, we also studied direct effects on enzymes rat steroidogenic pathway. One patient who was a 20-hour infusion (1.3 1.5 mg per kilogram body weight hour) had marked adrenocortical suppression that still evident four days after discontinued. Four surgical...
The pharmacokinetic and pharmacodynamic properties of propofol were studied in 50 surgical patients. Propofol was administered as a bolus dose, 2 mg/kg iv, followed by variable-rate infusion, 0-20 mg/min, intermittent supplemental boluses, 10-20 mg part general anesthetic technique that included nitrous oxide, meperidine, muscle relaxants. For majority the patients (n = 30), pharmacokinetics best described two-compartment model. mean total body clearance rate 2.09 +/- 0.65 1/min (mean SD),...
The bispectral (BIS) index and 95% spectral edge frequency (SEF) of the electroencephalograph (EEG) have been used to study anesthetic sedative effects intravenously (IV) administered drugs.This prospective was designed evaluate effectiveness BIS SEF for assessing level propofol-induced sedation amnesia during regional anesthesia. Ten consenting adult patients undergoing surgery with anesthesia were propofol in increments 10-20 mg IV, every 5-10 min until they became unresponsive tactile...
Background The bispectral (BIS) index has previously been shown to be a quantifiable measure of the sedative and hypnotic effects anesthetic drugs. This study was designed assess effect BIS monitoring on utilization volatile anesthetics their recovery profiles after ambulatory surgery. Methods Sixty consenting women undergoing outpatient laparoscopic tubal ligation procedures were randomly assigned one four treatment groups. After standardized induction, anesthesia maintained with either...
To assess the intraoperative and postoperative effects of optical isomers ketamine. compared with racemic mixture as sole anesthetics, equianesthetic doses ketamine (RK), 2 mg/kg, (+)ketamine (PK), 1 (−)ketamine (MK), 3 were administered intravenously in a ran
Bispectral analysis (BIS) of the electroencephalogram (EEG) has been shown in retrospective studies to predict whether patients will move response skin incision.This prospective multicenter study was designed evaluate real-time utility BIS predicting movement incision using a variety general anesthetic techniques. Three hundred from seven sites received an regimen expected give approximately 50% at incision. EEG continuously recorded via Aspect B-500 monitor and calculated real time...
In Brief BACKGROUND: Dexmedetomidine (Dex), an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this prospective, randomized, double-blind, placebo-controlled dose-ranging study to evaluate the effect of Dex on both early late recovery after laparoscopic bariatric surgery. METHODS: Eighty consenting ASA II–III morbidly obese patients were randomly assigned 1 4 treatment groups: (1) control group received a saline infusion during surgery, (2) 0.2 μg · kg−1 h−1...
The NaV1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role transmitting signals. effect of VX-548, an oral, highly selective inhibitor NaV1.8, on control acute pain is being studied.
A need exists for a safe and effective oral preanesthetic medication use in children undergoing elective surgical procedures. We evaluated the effectiveness of three different doses midazolam when administered combination with atropine prior to ambulatory surgery. In this randomized, double-blind, placebo-controlled study, 124 children, ages 1-10 yr, received midazolam, 0.25, 0.50, or 0.75 mg.kg-1 po, atropine, 0.03 mixed apple juice, placebo (containing vehicle, juice). blinded observer...
Bispectral analysis (BIS) of the electroencephalogram (EEG) has been shown in retrospective studies to predict whether patients will move response skin incision.This prospective multicenter study was designed evaluate real-time utility BIS predicting movement incision using a variety general anesthetic techniques. Three hundred from seven sites received an regimen expected give approximately 50% at incision. EEG continuously recorded via Aspect B-500 monitor and calculated real time...
The use of an ilioinguinal-hypogastric nerve block (IHNB) as part a monitored anesthesia care (MAC) technique has been associated with rapid recovery profile for outpatients undergoing inguinal herniorrhaphy procedures. This study was designed to compare the cost-effectiveness IHNB-MAC standardized general and spinal anesthetics techniques in ambulatory setting. We randomly assigned 81 consenting receive IHNB-MAC, anesthesia, or anesthesia. evaluated times, 24-h postoperative side effects...
Postoperative adrenocortical function was compared in 23 out-patients receiving either thiopental, 4 mg/kg, for induction and a thiopental infusion, 0.26 mg . kg-1 min-1, combination with nitrous oxide 70% maintenance of anesthesia (control); etomidate, 0.4 followed by an etomidate 0.02 (etomidate I); or 0.22 II). The norepinephrine response to surgery did not differ significantly between the three groups. postoperative cortisol ACTH stimulation normal control group (maximum rise plasma 20.1...
Given the inherent side effects associated with both opioid and nonopioid analgesic drugs, a nonpharmacologic therapy that could decrease need for medication would be valuable.We designed shamcontrolled study to assess effect of intensity transcutaneous acupoint electrical stimulation (TAES) on postoperative patient-controlled analgesia (PCA) requirement hydromorphone (HM), incidence opioid-related effects, recovery profile after lower abdominal surgery. One hundred one healthy consenting...