A5070015565- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Mechanisms and Treatments
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Inflammatory mediators and NSAID effects
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Acupuncture Treatment Research Studies
- Anesthesia and Neurotoxicity Research
- Pain Management and Placebo Effect
- Nerve injury and regeneration
- Pain Management and Treatment
- Neurogenetic and Muscular Disorders Research
- Congenital limb and hand anomalies
- Restraint-Related Deaths
- Autoimmune Neurological Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Optical Imaging and Spectroscopy Techniques
- Peripheral Neuropathies and Disorders
- Orthopedic Surgery and Rehabilitation
- Pain Management and Opioid Use
Cedars-Sinai Medical Center
2001-2023
Medical University of South Carolina
2023
University of Arizona
2023
Phoenix (United States)
2023
University of California, Los Angeles
2023
University of California, Riverside
2017
Policlinico Abano Terme
2012
The University of Texas Southwestern Medical Center
1997-2002
Abstract Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may contribute disease glial cell line-derived neurotrophic factor (GDNF) can be protective. Here we show that human neural progenitor cells transduced with GDNF (CNS10-NPC-GDNF) differentiated protected spinal neurons were safe in animal models. CNS10-NPC-GDNF transplanted unilaterally into the lumbar cord 18...
Given the inherent side effects associated with both opioid and nonopioid analgesic drugs, a nonpharmacologic therapy that could decrease need for medication would be valuable.We designed shamcontrolled study to assess effect of intensity transcutaneous acupoint electrical stimulation (TAES) on postoperative patient-controlled analgesia (PCA) requirement hydromorphone (HM), incidence opioid-related effects, recovery profile after lower abdominal surgery. One hundred one healthy consenting...
BACKGROUND: There is controversy regarding the relative perioperative benefits of desflurane versus sevoflurane when used for maintenance anesthesia in ambulatory setting. Although studies have consistently demonstrated a faster emergence with (versus sevoflurane), impact this difference on later recovery end points has not been definitively established. Furthermore, effect sevoflurane) incidence coughing also controversial. METHODS: We randomized 130 outpatients undergoing superficial...
Transcutaneous electrical nerve stimulation (TENS) has been used as a complementary (supplemental) therapy to opioid analgesics for pain relief after surgery. Simultaneous at classical Chinese acupoint site and periincisional dermatomes significantly decreases the postoperative analgesic requirement. This sham-controlled study was designed assess relative effectiveness of versus nonacupoint on hydromorphone (HM) requirement, incidence opioid-related side effects, overall recovery profile....
Background Office-based surgery is becoming increasingly popular because of its cost-saving potential Both propofol and sevoflurane are commonly used in the ambulatory setting their favorable recovery profiles. This clinical investigation was designed to compare effects, characteristics, cost-effectiveness when alone or combination for office-based anesthesia. Methods One hundred four outpatients undergoing superficial surgical procedures at an center were randomly assigned one three general...
We evaluated the cognitive recovery profiles in elderly patients after general anesthesia with desflurane or sevoflurane. After IRB approval, 70 ASA physical status I–III consenting (≥65 yr old) undergoing total knee hip replacement procedures were randomly assigned to one of two anesthetic groups. Propofol and fentanyl administered for induction anesthesia, followed by either 2%–4% sevoflurane 1%–1.5% nitrous oxide 65% oxygen. The (2.5 ± 0.6 MAC · h) (2.7 0.5 concentrations adjusted...
To compare three different video laryngoscope devices (VL) to standard direct laryngoscopy (DL) for tracheal intubation of obese patients undergoing bariatric surgery.VL (vs DL) would reduce the time required achieve successful and improve glottic view.Prospective, randomized controlled.Preoperative/operating rooms postanesthesia care unit.One hundred twenty-one (ASA physical status I-III), aged 18 80 years, body mass index (BMI) >30 kg/m(2) elective surgery.Patients were prospectively...
Background The analgesic efficacy and side effect profile of intravenous parecoxib, a novel cyclooxygenase type-2 (COX-2) inhibitor, was assessed in double-blinded, placebo-controlled study involving patients undergoing major gynecologic surgical procedures. Methods After Institutional Review Board approval, 60 consenting women, American Society Anesthesiologists (ASA) physical status I-III, lower abdominal surgery with standardized general anesthetic technique were randomly assigned to...
In Brief There is controversy regarding the optimal technique for maintaining hemodynamic stability during anesthesia. We designed this prospective, randomized, double-blinded study to test hypothesis that used general anesthesia can influence recovery after ambulatory surgery. Forty-five healthy consenting women undergoing gynecologic laparoscopy procedures were randomly assigned 1 of 3 treatment groups: Group (control, n = 15) received normal saline 5 mL and mL, followed by a infusion at...
In Brief BACKGROUND: Nonsteroidal antiinflammatory drugs have become increasingly popular as part of multimodal analgesic regimens for pain management in the ambulatory setting. We designed this randomized, double-blind, placebo-controlled study to evaluate effect postoperative administration either a nonselective nonsteroidal drug (ibuprofen) or cyclooxygenase-2 selective inhibitor (celecoxib when administered regimen) on severity pain, need rescue analgesics, and clinically relevant...
There is still controversy regarding the optimal strategy for managing postoperative nausea and vomiting (PONV) in high-risk surgical populations. Although acustimulation at P6 acupoint has been demonstrated to be effective preventing PONV, effect of this nonpharmacologic therapy on patient's recovery with respect resumption normal activities daily living not previously assessed when it used as part a multimodal antiemetic regimen. Therefore, we designed randomized, sham-controlled,...
IMPLICATIONS Compared to propofol, maintenance of anesthesia with desflurane provided significantly better intraoperative conditions during office-based surgery. In addition, routine antiemetic prophylaxis was associated a faster early recovery and similar incidence postoperative side effects.
Cerebral monitoring indices are associated with a large degree of inter-patient variability and electrical signal interference during surgery. We designed this clinical study to test the hypothesis that use spectral entropy (Entropy) module is less frequent intraoperative displayed than bispectral index (BIS) monitor when used general anesthesia propofol desflurane. Thirty consenting patients scheduled for major laparoscopic surgery procedures were enrolled in prospective study. The elapsed...
To compare the C-MAC video laryngoscope to standard flexible fiberoptic scope (FFS) with an eye piece (but without a camera or screen) for intubation of patients undergoing cervical spine surgery manual inline stabilization. The primary end point was time achieve successful tracheal intubation. Secondary points included glottic view at and number attempts.Prospective, randomized, single-blinded study.Cedars Sinai Medical Center in Los Angeles, CA.One hundred forty (American Society...
Non-opioid analgesics have become increasingly popular as part of a multimodal regimen for pain management in the ambulatory setting. We designed this randomized, double-blind, placebo-controlled study to evaluate effect perioperative administration cyclooxygenase-2 inhibitor rofecoxib on patient outcome after inguinal herniorrhaphy procedures. Sixty consenting outpatients undergoing elective hernia repair surgery were randomly assigned one two treatment groups: control (vitamin C, 500 mg)...
Background Office-based surgery has become increasingly popular because of its cost-saving potential. However, the occurrence postoperative nausea and vomiting (PONV) can delay patient discharge. Prophylaxis using a combination antiemetic drugs been suggested as an effective strategy for minimizing PONV. The authors designed this randomized, double-blinded, placebo-controlled study to assess efficacy ondansetron dolasetron when administered in with droperidol dexamethasone routine...
In Brief Based on comparative studies in patients receiving emetogenic chemotherapy, it has been suggested that granisetron would be more effective than ondansetron for the prevention of postdischarge nausea and vomiting (PDNV). However, there have no direct comparisons these two popular 5-HT3 antagonists with respect to PDNV quality recovery. We designed this randomized, double-blind study compare antiemetic efficacy oral (1 mg) a standard IV dose (4 when administered prophylaxis as part...
Dolasetron (12.5 mg IV) is effective in both preventing and treating postoperative nausea vomiting (PONV) after ambulatory surgery. However, the optimal timing of dolasetron administration its effect on patient’s quality life discharge have not been established. One-hundred-five healthy, consenting women undergoing gynecologic laparoscopic procedures with a standardized general anesthetic technique were enrolled this randomized, double-blinded study. Group 1 received 12.5 IV 10–15 min before...
Given the inherent side effects associated with both opioid and nonopioid analgesic drugs, a nonpharmacologic therapy that could decrease need for medication would be valuable.We designed shamcontrolled study to assess effect of intensity transcutaneous acupoint electrical stimulation (TAES) on postoperative patient-controlled analgesia (PCA) requirement hydromorphone (HM), incidence opioid-related effects, recovery profile after lower abdominal surgery. One hundred one healthy consenting...
Transcutaneous electrical nerve stimulation (TENS) has been used as a complementary (supplemental) therapy to opioid analgesics for pain relief after surgery.Simultaneous at classical Chinese acupoint site and periincisional dermatomes significantly decreases the postoperative analgesic requirement. This sham-controlled study was designed assess relative effectiveness of versus nonacupoint on hydromorphone (HM) requirement, incidence opioid-related side effects, overall recovery profile. One...
White, Paul F.; Tang, Jun; Wender, Ronald H.; Zhao, Manxu; Time, Michael; Zaentz, Alan; Yumul, Roya; Sloninsky, Alexander; Naruse, Robert; Kariger, Webb, Tom; Fermelia, David E.; Tsushima, Gregory K. Author Information
Rubinstein-Taybi Syndrome (RSTS) is an autosomal dominant disorder that classically characterized by prenatal and postnatal growth restriction, microcephaly, dysmorphic craniofacial features, broad thumbs toes, intellectual disability. We describe the first reported case of a pituitary macroadenoma associated with RSTS. A 39-year-old Caucasian female past medical history RSTS diagnosed at age two was found to have gadolinium-enhancing mass on magnetic resonance imaging (MRI) brain three...
Progressive post-traumatic postsurgical myelopathy (PPPM) is a known entity that can occur months to years after the initial insult. Symptomatic patients become myelopathic and have rapid progressive neurological decline. Surgical correction of PPPM usually involves intradural exploration lysis adhesions carries risk further injury spinal cord. In this manuscript, we provide report patient presenting more than 50 resection an intramedullary tumor. Additionally, present describe novel...