A5103220534- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Carbohydrate Chemistry and Synthesis
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
Capricor Therapeutics (United States)
2023
Friedrich Miescher Institute
2017
ETH Zurich
2015
Abstract Posttranslational modifications (PTMs) are an integral part of the majority proteins. The characterization structure and function PTMs can be very challenging especially for glycans. Existing methods to analyze require complicated sample preparations suffer from missing certain modifications, inability identify linkage types thus chemical structure. We present a direct, robust, simple NMR spectroscopy method detection identification in No isotope labeling is required, nor does...
Abstract Posttranslational modifications (PTMs) are an integral part of the majority proteins. The characterization structure and function PTMs can be very challenging especially for glycans. Existing methods to analyze require complicated sample preparations suffer from missing certain modifications, inability identify linkage types thus chemical structure. We present a direct, robust, simple NMR spectroscopy method detection identification in No isotope labeling is required, nor does...
Targeted Protein Degradation (TPD) is an emerging new modality of drug discovery that offers unprecedented therapeutic benefits over traditional protein inhibition. Most importantly, TPD unlocks the untapped pool proteome to date has been considered undruggable. Captor Therapeutics (Captor) fourth global, and first European, company develops small molecule candidates based on principles targeted degradation. located in Basel, Switzerland Wroclaw, Poland exploits best opportunities two sites...
Abstract A comparative analysis of recombinant expression in E. coli three HECT E3 ligases reveals a consistent preference for lower temperatures. Lower temperatures prevent aggregation and misfolding, enhancing the efficiency solubility expressed ligases. Isolated domains generally exhibit higher success compared to full-length counterparts, offering improved yields. However, levels vary among ligases, necessitating tailored strategies. Future studies may explore HECT-type covalent...