A5056577783- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Pediatric health and respiratory diseases
- Bacteriophages and microbial interactions
- Infant Health and Development
- Adolescent and Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Enzyme-mediated dye degradation
- Genomics and Phylogenetic Studies
- Gastrointestinal motility and disorders
- Infant Development and Preterm Care
- Plant tissue culture and regeneration
- Colorectal Cancer Screening and Detection
- Plant Gene Expression Analysis
- Inflammatory Bowel Disease
- Probiotics and Fermented Foods
- Microbial Community Ecology and Physiology
- Diabetes and associated disorders
University of Helsinki
2018-2023
Maastricht University
2023
APC Microbiome Institute
2018
University College Cork
2018
Birth mode and maternal intrapartum (IP) antibiotics affect infants' gut microbiota development, but their relative contribution to absolute bacterial abundances infant health has not been studied. We compared the effects of Cesarean section (CS) delivery IP on development well-being over first year. focused 92 healthy infants born between gestational weeks 37–42 vaginally without (N = 26), with penicillin 13) or cephalosporin 7) by CS 33) other 13). Composition temporal analysis...
Although the infant gut microbiota has been extensively studied, comprehensive assessment on determinants including technical variables not performed in large cohorts.
Bifidobacteria are common members of the gastro-intestinal microbiota a broad range animal hosts. Their successful adaptation to this particular niche is linked their saccharolytic metabolism, which supported by wide glycosyl hydrolases. In current study large-scale gene-trait matching (GTM) effort was performed explore glycan degradation capabilities in B. breve. By correlating presence/absence genes and associated genomic clusters with growth/no-growth patterns across dataset 20...
Purpose HELMi (Health and Early Life Microbiota) is a longitudinal, prospective general population birth cohort, set up to identify environmental, lifestyle genetic factors that modify the intestinal microbiota development in first years of life their relation child health well-being. Participants The cohort consists 1055 healthy term infants born 2016–2018 mainly at capital region Finland parents. characterised based on nine, strategically selected, faecal samples connected extensive online...
Birth mode and other early life factors affect a newborn's microbial colonization with potential long-term health effects. Individual variations in gut microbiota development, especially their effects on the functional repertoire of microbiota, are still poorly characterized. This study aims to provide new insights into microbiome developmental trajectories during first year life.Our comprised 78 term infants sampled at 3 weeks, months, 6 12 months (n = 280 total samples), mothers were late...
Biogeographic variations in the gut microbiota are pivotal to understanding global pattern of host–microbiota interactions prevalent lifestyle-related diseases. Pakistani adults, having an exceptionally high prevalence type 2 diabetes mellitus (T2D), one most understudied populations research date. The aim present study is examine across individuals from Pakistan and other non-industrialized industrialized lifestyles with a focus on T2D. fecal samples 94 urban-dwelling adults without T2D...
Abstract Background The role of intestinal microbiota in inflammatory bowel diseases is intensively researched. Pediatric studies on the relation between and treatment response are sparse. We aimed to determine whether absolute abundances gut microbes characterize infliximab induction pediatric disease. Methods recruited patients with disease introduced at Children’s Hospital, University Helsinki. Stool samples were collected 0, 2, 6 weeks for calprotectin analyses. defined as fecal value...
The acquisition and gradual maturation of gut microbial communities during early childhood is central to an individual's healthy development. Bacteriophages have the potential shape bacterial communities. However, complex ecological interactions between phages their host are still poorly characterized. In this study, we investigated abundance diversity integrated prophages in infant adult bacteria by detecting metagenome assembled genomes (MAGs) commensal bacteria.
Infants born by cesarean section have an intestinal microbiota that differs from of infants delivered vaginally. Here, we report a protocol for performing oral transplantation maternal fecal to newborn elective section. The crucial step this is the health screening process. This can only be applied healthy mothers and infants. For complete details on use execution protocol, please refer Korpela et al. (2020).
Abstract Background A complication of cesarean section delivery is its interference with the normal intestinal colonization infant, affecting development immune system in early life—a process that has been associated long-term morbidity, such as allergy and diabetes. We evaluated, CS-delivered infants, whether microbiome life could be restored by immediate postnatal transfer maternal fecal microbiota to newborn. Methods Seventeen healthy mothers planned elective CS were recruited screened...
Abstract Biogeographic variations in the gut microbiota reflect host and environmental factors delineating human populations, are pivotal to understand global patterns of host-microbiota interactions health prevalent lifestyle-related diseases, such as type 2 diabetes mellitus (T2D). Pakistani adults, having an exceptionally high prevalence T2D, one most understudied populations research date. The aim present study is examine across individuals from Pakistan other non-industrialized...
Abstract Background and aims Caesarean section (CS)-birth maternally administered intrapartum antibiotics (IP) affect colonization of the neonate. We compared effects CS delivery IP on infant gut microbiota development wellbeing over first year. To understand developing community dynamics, we focused absolute bacterial abundance estimates relative abundances. Methods studied 144 healthy infants born between gestational weeks 37-42 vaginally without (N=58), with penicillin (N=25) or...
Background: Although the infant gut microbiota has been extensively studied, comprehensive assessment on covariates including technical variables not performed in large cohorts.Methods:We studied effect of 109 16S rRNA gene amplicon-based profiles infants sampled longitudinally over first two years life Finnish HELMi birth cohort. Spot faecal samples from both parents were included for intra-family analyses, totalling to 7660 985 families that evaluated beta-diversity patterns using...