A5046569957- Gut microbiota and health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Clostridium difficile and Clostridium perfringens research
- Infant Health and Development
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Food composition and properties
- Dietary Effects on Health
- Nutrition, Genetics, and Disease
- Agriculture Sustainability and Environmental Impact
- Genomics and Phylogenetic Studies
- Microbial Metabolites in Food Biotechnology
- Nutritional Studies and Diet
- Infant Nutrition and Health
- Proteins in Food Systems
- Adolescent and Pediatric Healthcare
- Polysaccharides and Plant Cell Walls
- Oral microbiology and periodontitis research
- Complementary and Alternative Medicine Studies
- Phytoestrogen effects and research
- Ginger and Zingiberaceae research
- Animal Behavior and Welfare Studies
- Phytochemicals and Antioxidant Activities
University of Helsinki
2018-2025
Anhui Xinhua University
2025
Institute for Biomedicine
2018
OBJECTIVE Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis hepatic de novo lipogenesis (DNL) are the main pathways contributing IHTG. We hypothesized that dietary macronutrient composition influences pathways, mediators, magnitude of weight gain-induced changes in RESEARCH DESIGN AND METHODS overfed 38 overweight subjects (age 48 ± years, BMI 31 1 kg/m2, fat 4.7...
The use of relative abundance data from next generation sequencing (NGS) can lead to misinterpretations microbial community structures, as the increase one taxon leads concurrent decrease other(s) in compositional data. Although different DNA- and cell-based methods well statistical approaches have been developed overcome compositionality problem, biological relevance absolute bacterial abundances has demonstrated, human microbiome research not yet adopted these methods, likely due...
Obesity is a major risk factor for the development of type 2 diabetes and cardiovascular diseases, gut microbiota plays key role in influencing host energy homeostasis. Moreover, obese mice have different composition, associated with an alteration intestinal mucus layer, which represents interface between bacteria host. We previously demonstrated that prebiotic treatment oligofructose (FOS) counteracted effects diet-induced obesity, together changes but it not known if layer could be...
Abstract Background Low-energy diets (LEDs) comprise commercially formulated food products that provide between 800 and 1200 kcal/day (3.3–5 MJ/day) to aid body weight loss. Recent small-scale studies suggest LEDs are associated with marked changes in the gut microbiota may modify effect of LED on host metabolism We investigated how changed during 8 weeks total meal replacement determined their associations response a sub-analysis 211 overweight adults pre-diabetes participating large...
Small-scale studies investigating the relationship between pigs' intestinal microbiota and growth performance have generated inconsistent results. We hypothesized that on farms under favorable environmental conditions (e.g., promoting sow nest-building behavior, high colostrum production, low incidence of diseases minimal use antimicrobials), piglet gut may develop toward a population promotes reduces pathogenic bacteria. Using 16S rRNA gene amplicon sequencing, we sampled profiled fecal...
To decipher the mechanisms by which major human milk oligosaccharide (HMO), 2'-fucosyllactose (2'FL), can affect body weight and fat mass gain on high-fat diet (HFD) feeding in mice. We wanted to elucidate whether 2'FL metabolic effects are linked with changes intestinal mucus production secretion, mucin glycosylation degradation, as well modulation of gut microbiota, faecal proteome endocannabinoid (eCB) system.
Birth mode and maternal intrapartum (IP) antibiotics affect infants' gut microbiota development, but their relative contribution to absolute bacterial abundances infant health has not been studied. We compared the effects of Cesarean section (CS) delivery IP on development well-being over first year. focused 92 healthy infants born between gestational weeks 37–42 vaginally without (N = 26), with penicillin 13) or cephalosporin 7) by CS 33) other 13). Composition temporal analysis...
Food systems worldwide have become industrialized over the past century with impacts on diets, nutrition and health. The trade-offs between affordability higher-quality diets can be exemplified by industrially produced, refined wheat bread. There is substantial demand for designing healthier bread, host-microbiota commensalism has emerged as a key factor in food product development aiming to deliver health benefits. Based pre-clinical clinical studies, this review provides an overview of...
Perinatal and early-life factors reported to affect risk of allergic diseases may be mediated by changes in the gut microbiota. Here, we explored associations between infant microbiota morbidity childhood until 13 years age a subgroup FLORA probiotic intervention cohort. A mixture four strains with galacto-oligosaccharides was administrated mothers from 36th week pregnancy later their infants 6 months age. The were monitored for manifestations atopic eczema, food allergy, rhinitis, asthma...
Birch-derived glucuronoxylan (GX)-rich hemicellulose extract is an abundantly available by-product of the forest industry. It has multifunctional food stabilizing properties, and rich in fiber polyphenols. Here, we studied its effects on colonic metabolism gut microbiota healthy rats. Male female Wistar rats (n = 42) were fed AIN-93G-based diets with 10% (w/w) either cellulose (control), a polyphenol GX-rich (GXpoly), or highly purified (pureGX) for four weeks. Both GXpoly pureGX resulted...
While previously considered inert, recent studies suggest lignin metabolism with unknown metabolic fates is occurring in the gastrointestinal tract of several animal models. This study focuses on analyzing potential metabolites lignin.The diets rats include relatively pure birch glucuronoxylan (pureGX) residual or lignin-rich GX (GXpoly) their diet. Nuclear magnetic spectroscopy isolated from GXpoly-fed fecal sample shows high alteration chemical structure, whereas lignin-carbohydrate...
Biogeographic variations in the gut microbiota are pivotal to understanding global pattern of host–microbiota interactions prevalent lifestyle-related diseases. Pakistani adults, having an exceptionally high prevalence type 2 diabetes mellitus (T2D), one most understudied populations research date. The aim present study is examine across individuals from Pakistan and other non-industrialized industrialized lifestyles with a focus on T2D. fecal samples 94 urban-dwelling adults without T2D...
Ultrasound-assisted extraction technology was utilized to extract total flavonoids from Chaenomeles speciosa (Sweet) Nakai, and response surface methodology employed optimize the process. The anti-oxidant lipoxygenase inhibitory activities were evaluated, along with an analysis of type inhibition. results revealed that optimal conditions for Nakai as follows: ethanol concentration 62%, a liquid-to-solid ratio 15:1 mL/g, ultrasonic temperature 68°C, time 40 min, resulting in flavonoid rate...
Rheological tests performed under conditions relevant to those experienced during proof and oven rise are necessary for understanding the mechanisms of dextran addition on wheat dough baking performance. This study evaluated effect a high molecular weight (Mw) dextran, produced in situ by Weissella confusa A16 or externally added, rheological properties including, (i) proofing behavior using maturograph; (ii) bi-axial extensional profile inflation system; (iii) viscoelastic characters...
Abstract The use of relative next generation sequencing (NGS) abundance data can lead to misinterpretations microbial community structures as the increase one taxon leads concurrent decrease other(s). To overcome compositionality, we provide a quantitative NGS solution, which is achieved by adjusting 16S rRNA gene amplicon with PCR (qPCR-based) total bacterial counts. By comparing enumeration dominant groups on different taxonomic levels in human fecal samples using taxon-specific...
Abstract Background Intestinal botulism is primarily reported in small babies as a condition known infant botulism. The results from the ingestion of environmental or foodborne spores botulinum neurotoxin (BoNT) producing Clostridia , usually Clostridium and subsequent spore germination into active neurotoxinogenic cultures gut. It generally considered that are susceptible to C. colonization because their immature gut microbiota. Yet, it poorly understood which host factors contribute...
Pectin and its derivatives have been shown to modulate immune signaling as well gut microbiota in preclinical studies, which may constitute the mechanisms by supplementation of specific pectic polysaccharides confers protection against viral respiratory infections. In a double-blind, placebo-controlled rhinovirus (RV16) challenge study, healthy volunteers were randomized consume placebo (0.0 g/day) (N = 46), low-dose (0.3 49) or high-dose (1.5 51) carrot derived rhamnogalacturonan-I (cRG-I)...