A5012554277- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Preterm Birth and Chorioamnionitis
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Maternal and fetal healthcare
- Parvovirus B19 Infection Studies
- Plant Pathogens and Fungal Diseases
- Biomarkers in Disease Mechanisms
- RNA modifications and cancer
- Fetal and Pediatric Neurological Disorders
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Nuclear Receptors and Signaling
- Fungal Infections and Studies
- Pregnancy-related medical research
The University of Melbourne
2016-2025
Mercy Hospital for Women
2016-2025
Walter and Eliza Hall Institute of Medical Research
2024-2025
Northern Health
2021-2025
Tokyo University of Pharmacy and Life Sciences
2015-2017
Manchester University
2017
St Mary's Hospital
2017
Manchester Academic Health Science Centre
2017
St. Mary's Hospital
2017
Osaka University
2017
Preeclampsia is a severe complication of pregnancy. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and endoglin are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, multiorgan injury. Oxidative stress vascular inflammation exacerbate A drug that can block these pathophysiological steps would be an attractive treatment option. Proton pump inhibitors (PPIs) safe pregnancy where they prescribed for gastric reflux. We performed functional...
Fetal growth restriction (FGR) is a major obstetric complication stemming from poor placental development. We have previously demonstrated that paternal obesity in mice associated with impaired embryo development and significantly reduced fetal weights. hypothesised the FGR observed our rodent model of diet-induced alterations metabolic, cell signalling stress pathways. Male C57BL/6 were fed either normal or high-fat diet for 10 weeks before sperm collection IVF subsequent transfer. On...
Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. The antiangiogenic factor, sFlt-1 (soluble FMS-like tyrosine kinase-1) has been strongly implicated in the pathogenesis preeclampsia. secreted into circulation where it antagonizes VEGF (vascular growth factor) ultimately disrupts vascular homeostasis. However, upstream mechanisms regulating release are poorly characterized. We investigated roles key prosurvival...
Preeclampsia affects ∼2-8% of pregnancies worldwide. It is associated with increased long-term maternal cardiovascular disease risk. This study assesses the effect vasoconstrictor N(ω)-nitro-L-arginine methyl ester (L-NAME) in modelling preeclampsia mice, and its effects on health. In this study, we found that L-NAME administration mimicked key characteristics preeclampsia, including elevated blood pressure, impaired fetal placental growth, circulating endothelin-1 (vasoconstrictor), soluble...
Abstract Preeclampsia is a disease of pregnancy associated with placental oxidative stress, inflammation and elevated release anti-angiogenic factors sFlt-1 soluble endoglin. These cause generalized maternal endothelial dysfunction. There are no treatments to halt progression; delivery the only cure. Resveratrol modulates pathways involved in stress may offer potential therapeutic for preeclampsia. reduced sFlt-1, e15a endoglin secretion from primary trophoblasts HUVECs mRNA expression...
BACKGROUND: Many reports document the transmission of human parvovirus B19 (B19) infection by clotting factor concentrates manufactured from large plasma pools. Transmission via other blood components originating a single donor or small number donors, however, seems to occur only rarely. The study reported here identifies that was transmitted platelet donation. CASE REPORT: A multiply transfused allogeneic bone marrow transplant patient developed chronic anemia due persistent infection....
Preeclampsia is a severe complication of pregnancy, characterized by hypertension, oxidative stress, and endothelial dysfunction. Antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) endoglin, play key pathophysiological roles in preeclampsia. Heme oxygenase-1 (HO-1) cytoprotective, antioxidant enzyme reported to be downregulated Studies propose that inducing HO-1 may also decrease sFlt-1 production. Sofalcone, gastric antiulcer agent clinical use, known induce epithelium. We...
Introduction The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and endoglin (sENG) are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, multiorgan injury. We recently identified metformin esomeprazole as potential for preeclampsia. Both reduce placental secretion sFlt-1 endoglin, dysfunction. Objectives set out to assess whether combining...
Preeclampsia is one of the most serious complications pregnancy. Currently there are no medical treatments. Given placental oxidative stress may be an early trigger in pathogenesis preeclampsia, therapies that enhance antioxidant pathways have been proposed as Melatonin a direct free-radical scavenger and indirect antioxidant. We performed vitro assays to assess whether melatonin 1) enhances response element genes (heme-oxygenase 1, (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H:quinone...
Elevated placental release of the antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) and endoglin (sENG), is central to pathophysiology preeclampsia. It widely accepted that heme oxygenase-1 (HO-1) decreased in preeclamptic placenta negatively regulates sFlt-1 sENG production. We set out verify these contentions. There was no difference HO-1 mRNA or protein levels preterm placentas (n=17) compared with gestationally matched controls (n=27). In silico analysis microarray...
Abstract Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted acidemic, can demise. Preterm fetal restriction is a severe form of with high risk stillbirth. We set out to identify maternal circulating mRNA transcripts that are differentially expressed in preterm pregnancies complicated very insufficiency, utero acidemia, at Methods performed cohort study across six hospitals Australia New Zealand, prospectively...
The peptide relaxin has gained considerable attention as a new vasoactive drug, largely through its beneficial therapeutic effects in cardiovascular disease. In this study, we tested the hypothesis that treatment alleviates systemic vascular dysfunction characteristic of hypertensive diseases pregnancy. We investigated and mechanisms action (i) pregnant relaxin-deficient (Rln-/-) mice with enhanced responses to angiotensin II (AngII) (ii) arteries pre-incubated ex vivo trophoblast...
DNA methyltransferase 1 inhibitor (DNMT1i) therapy is a promising option for increasing immune response as part of combination cancer therapy. High–grade serous ovarian carcinoma (HGSOC) highly aggressive with poor survival outcomes, where DNMT1i being increasingly explored. HGSOC epigenetically silenced BRCA1 has been shown to respond PARP (PARPi) treatment – core targeted HGSOC. However, loss silencing even single allele causes PARPi and platinum chemotherapy resistance. We tested whether...
Amniotic fluid (AF) is a valuable source of extracellular vesicles (EVs) derived from the fetoplacental unit. Preclinical and clinical studies have highlighted promising applications AF-EVs their role in cellular communication, yet our understanding AF-EV physiology limited. This study aimed to examine physiological importance fetal development second trimester term gestation. We obtained AF samples routine second-trimester amniocentesis prelabour Caesarean section at term. isolated EVs...
Background: Preeclampsia is a leading cause of maternal and fetal morbidity mortality, with obesity recognised as significant risk factor. However, the direct contribution to pathophysiology underpinning preeclampsia remains unclear. Objectives: This study aimed develop characterise diet-induced obese mouse model superimposed better understand impact on disease pathogenesis. Methods: Female mice were fed either standard rodent chow or high-fat diet from weaning. At 8 weeks age, mated....
Congenital cytomegalovirus (CMV) infection is the leading preventable cause of childhood disability, including sensorineural hearing loss and cerebral palsy in high-income countries. Early maternal treatment with valaciclovir has been shown to reduce fetal infection. However, newer, more potent anti-CMV medications such as letermovir maribavir are not routinely used pregnancy due limited safety data. This study aimed assess effect aciclovir (the active metabolite valaciclovir), letermovir,...
Abstract Penicillium marneffei is an opportunistic human pathogen endemic to Southeast Asia. At 25° P. grows in a filamentous hyphal form and can undergo asexual development (conidiation) produce spores (conidia), the infectious agent. 37° pathogenic yeast cell that replicates by fission. Switching between these growth forms, known as dimorphic switching, dependent on temperature. To understand process of switching physiological capacity different types, two microarray-based profiling...