A5001155140- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Diagnosis and treatment of tuberculosis
- Congenital Diaphragmatic Hernia Studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Medical Imaging and Pathology Studies
- Infectious Diseases and Tuberculosis
- Ultrasound in Clinical Applications
- Esophageal and GI Pathology
- Cardiac tumors and thrombi
- Prenatal Substance Exposure Effects
- Tumors and Oncological Cases
- Gestational Diabetes Research and Management
- Foreign Body Medical Cases
- COVID-19 Clinical Research Studies
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Head and Neck Anomalies
- Congenital Anomalies and Fetal Surgery
- Parasitic infections in humans and animals
- Preterm Birth and Chorioamnionitis
Stellenbosch University
2016-2025
National Health Laboratory Service
2016-2025
Tygerberg Hospital
2016-2025
Western Cape Department of Health
2022
Tygerberg Children’s Hospital
2019
University of South Dakota
2016
Sanford Research
2016
Research Network (United States)
2016
Boston Children's Hospital
2010-2016
Harvard University
2016
Transthoracic ultrasound (US) has gained popularity as a tool for visualizing pleural effusions and assisting thoracentesis or chest drain placement. In the absence of effusion, US just well demonstrates solid masses involving abutting pleura, yet biopsy such lesions is not widely performed by physicians.To assess feasibility safety US-assisted cutting needle physicians in routine practice.Lesions pleura > =20 mm diameter on were sampled with 14-gauge under local anesthesia. Biopsy site,...
Objective. To compare histopathological differences in placentas from early- and late-onset preeclampsia, as well preeclampsia normal term deliveries. Methods. This prospective study was performed at Tygerberg Hospital, a secondary tertiary referral center South Africa. Placentas 100 women, 25 each with early an equal number of controls matched for gestational age, underwent routine preparation were evaluated independently by two pathologists strictly predetermined, standardized manner....
Sudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality. Although rate has plateaued, any unexpected an a family tragedy thus finding causes and contributors to risk remains major public health concern. The primary objective this investigation was determine patterns drinking smoking during pregnancy that increase SIDS.The Safe Passage Study prospective, multi-center, observational study with 10,088 women, 11,892 pregnancies, 12,029 fetuses, followed 1-year post...
The present study compared the diagnostic yield of ultrasound-assisted cutting-needle biopsy (CNB) and fine-needle aspiration (FNAB) in chest lesions. A physician performed ultrasound FNAB with a 22-G spinal needle all patients, directly followed by 14-G CNB patients without contraindication. total 155 consecutive lesions arising from lung (74%), pleura (12%), mediastinum (11%) or wall (3%) final diagnosis carcinoma other malignant tumours non-neoplastic disease (9%) unknown (5%) were...
Abstract Objectives To describe and correlate placental characteristics from pregnancies in HIV ‐infected ‐negative women with maternal infant clinical immunological data. Methods Prospective descriptive study of placentas term, uncomplicated vaginal births a cohort ( n = 120) 103) Cape Town, South Africa. Microscopic macroscopic features were used to determine pathological cluster diagnoses. The majority received some form drug treatment for the prevention vertical transmission . Data...
Anterior mediastinal masses in children can have different causes which includes, Mycobacterium tuberculosis (MTB) or malignant lymphadenopathy. Transbronchial needle aspiration (TBNA) has been described as a safe and effective diagnostic procedure adult patients with lung cancer.To describe the use of TBNA test large subcarinal lymphadenopathy to determine safety children.Prospective descriptive study lymph nodes who underwent TBNA. The majority were referred due treatment failure. Children...
Diagnosis of tuberculosis in children is challenging and fine needle aspiration biopsy (FNAB) used worldwide the diagnosis palpable masses including peripheral lymphadenopathy. Recent studies use nucleic acid amplification such as Xpert MTB/RIF test on FNAB adult patients have shown considerable promise. allows for rapid Mycobacterium identification rifampicin susceptibility. Studies to date been predominantly performed adults. This study aims determine accuracy detection M. complex from...
Ultrasound (US)-assisted transthoracic biopsy offers a less invasive alternative to surgical in the setting of mediastinal masses.The aim this 1-year prospective study was assess diagnostic yield and safety novel single-session sequential approach US-assisted fine-needle aspirations (TTFNA) with rapid on-site evaluation (ROSE) followed by cutting needle biopsies (CNB) performed physicians on patients anterosuperior masses.US-assisted TTFNA ROSE 45 consecutive (49.5 ± 27.7 years, 24 males),...
Physicians increasingly use transthoracic ultrasound (US) as an aid for diagnostic procedures. At the bedside, US helps to visualize neoplasms in chest wall, pleura, peripheral lung, and anterior mediastinum involving or abutting pleura. Histology specimens from cutting-needle biopsies have been shown be safe effective. This prospective study determined yield safety of US-guided fine-needle aspiration biopsy (FNAB) a first-line bedside investigation. We recruited 97 consecutive patients,...
Background This study investigated whether ‘unwanted pregnancy’ (i.e. a negative or ambivalent attitude towards the pregnancy/reproduction) is associated with schizophrenia-spectrum and affective disorders in offspring adulthood, if so, other pregnancy, perinatal, childhood genetic-risk factors account for this association. Method In prospective beginning during unwanted pregnancy (in combination early life risk factors) was studied relation to adult mental 75 genetic high-risk (HR) 91...
The yield and safety of ultrasound (US)-assisted transthoracic fine needle aspirations (TTFNA) cutting biopsies (CNB) in the setting superior vena cava (SVC) syndrome are unknown. aims present prospective study were to asses diagnostic US-assisted TTFNA CNB SVC with an associated mass lesion abutting chest wall. Over a 3-yr period, authors screened 59 patients syndrome, enrolled 25 who had that extended rapid on-site evaluation (ROSE) was performed all cases. CNBs where provisional diagnosis...
<i>Background:</i> Proximal lung tumors, though not discernable by means of transthoracic ultrasound (US), may cause varying degrees pulmonary collapse and postobstructive pneumonitis which give rise to a ‘drowned lung’ appearance on chest computed tomography (CT) US. The diagnostic yield for malignancy US-assisted fine-needle aspiration (FNA) these areas drowned is unknown. <i>Objectives:</i> We aimed explore the feasibility FNA in this setting prospectively...
The value of different staining methods for rapid analysis transbronchial needle aspirates during bronchoscopy has not been explored. In the present study, we compared a Papanicolaou-based stain, prepared by technologist and read cytopathologist, Wright-Giemsa-based cytopathologist alone. Gold standard was final laboratory report issued on each aspirate. We harvested 827 from 218 target sites in 126 consecutive patients. At least one positive aspirate found 99 (79%) those patients, 288 574...
Abstract Fine‐needle aspiration biopsy (FNAB) has been widely accepted as a reliable diagnostic modality in the general pediatric population, but its role oncology still remains elusive. With new treatment protocols subscribing to preoperative chemotherapy, need for quick, minimally invasive, and accurate procedure arisen. This study assesses feasibility of FNAB childhood malignancies render specific diagnosis on which can be initiated. An 11‐year retrospective was done FNABs patients 19...
Abstract Transbronchial needle aspiration (TBNA) via flexible bronchoscopy is a well‐established sampling modality for lung masses. The procedure useful in the diagnosis of neoplastic and non‐neoplastic lesions as well staging bronchogenic carcinoma. Rapid on‐site evaluation (ROSE) adds value it has advantage triaging material during so avoiding battery investigations. Frequently used rapid stains are modified Wright‐Giemsa water‐based stain (WG‐ROSE) alcohol‐based Papanicolaou (Pap‐ROSE)....