A5071549993- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- DNA and Nucleic Acid Chemistry
- Synthesis and Biological Evaluation
- Plant-based Medicinal Research
- Luminescence and Fluorescent Materials
- Metal complexes synthesis and properties
- Synthesis and Biological Activity
- Metal-Organic Frameworks: Synthesis and Applications
- Berberine and alkaloids research
- Essential Oils and Antimicrobial Activity
Instituto Tecnológico de Tijuana
2023
Tecnológico Nacional de México
2023
Universidad de Sonora
2018-2022
This work reports on the antibacterial activity of two tetrandrine derivatives, with acridine (MAcT) and anthracene (MAnT) units, against Gram-positive Gram-negative bacteria clinical importance by broth microdilution method as well their antioxidant ABTS•+ DPPH•+ radicals. Unlike natural tetrandrine, its derivatives inhibited bacterial growth, showing selectivity Staphylococcus aureus notable MAnT (MIC = 0.035 μg/mL); this compound also has good radical (IC50 4.59 μg/mL). Cell membrane...
Abstract Crystalline framework materials have gained interest because of their many potential applications. A novel chiral tetrandrine salt (DNT) has been synthesized and characterized by conventional analytical techniques single‐crystal X‐ray diffraction analysis, its self‐assembly behavior studied. In the solid state, 48 molecules compound self‐assemble into an organic based on nanospherical aggregates formed exclusively through weak noncovalent interactions. Additionally, it was...
A series of bis-N-substituted tetrandrine derivatives carrying different aromatic substituents attached to both nitrogen atoms the natural alkaloid were studied with double-stranded model DNAs (dsDNAs) examine binding properties and mechanism. Variable-temperature molecular recognition studies using UV-vis fluorescence techniques revealed thermodynamic parameters, ΔH, ΔS, ΔG, showing that exhibit high affinity toward dsDNA (K ≈ 105-107 M-1), particularly bis(methyl)anthraquinone (BAqT)...