A5050219177- Synthesis and Biological Evaluation
- Berberine and alkaloids research
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Synthesis and Biological Activity
- X-ray Diffraction in Crystallography
- Free Radicals and Antioxidants
- Crystallization and Solubility Studies
- Phytochemicals and Antioxidant Activities
- Bioactive natural compounds
- DNA and Nucleic Acid Chemistry
- Polysaccharides Composition and Applications
- Phytochemistry and Biological Activities
- Carbohydrate Chemistry and Synthesis
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Media, Journalism, and Communication History
- Inorganic and Organometallic Chemistry
- Essential Oils and Antimicrobial Activity
- Gut microbiota and health
- Synthesis and Reactivity of Heterocycles
- Biochemical and biochemical processes
- Hibiscus Plant Research Studies
- Political Theory and Democracy
- Chemical synthesis and pharmacological studies
Universidad de Sonora
2015-2025
Cancer is one of the leading causes death worldwide. Natural products have been regarded as important sources potential chemotherapeutic agents. In this study, we evaluated anti-proliferative activity Argemone gracilenta's methanol extract and its fractions. We identified those compounds most active fractions that displayed activity.The on different cancerous cell lines (M12.C3F6, RAW 264.7, HeLa) was in vitro using MTT colorimetric method. Identification present with highest achieved by...
We present the synthesis and characterization of organic Salphen compounds containing bromine substituents at para/ortho-para positions, in their symmetric non-symmetric versions, describe X-ray structure full for new unsymmetrical varieties. report first time antiproliferative activity metal-free brominated compounds, by evaluations four human cancer cell lines, cervix (HeLa), prostate (PC-3), lung (A549) colon (LS 180) one non-cancerous counterpart (ARPE-19). assessed vitro viability...
Triazoles occupy an important position in medicinal chemistry because of their various biological activities. The structural features 1,2,3-triazoles enable them to act as a bioisostere different functional groups such amide, ester, carboxylic acid, and heterocycle, being capable forming hydrogen bonds π-π interactions or coordinate metal ions with targets. In this work, the synthesis 1,2,3-triazole derivatives via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is reported....
Background: Despite advances for cancer treatment, it still remains a major worldwide public health problem. Compounds derived from natural sources are important alternatives to combat this mortal disease. Berberine is an isoquinoline alkaloid with wide variety of pharmacological properties, including antiproliferative activity. Previously, we have found that fatty acids also show activity against cell lines. Objective: To combine berberine and acids, or carboxylic in order improve their...
Cervical cancer is a malignant neoplastic disease, mainly associated to HPV infection, with high mortality rates. Among natural products, iridoids have shown different biological activities, including cytotoxic and antitumor effects, in cell types. Geniposide its aglycone Genipin been assessed against types of cancer. In this work, both were evaluated HeLa three cervical lines. Furthermore, we performed SAR analysis incorporating 13 structural similarity Genipin, also tested the line at same...
Background In Mexico, there is an ancestral custom about the knowledge of medicinal use plants. Bixa orellana L. a plant species that represents one main crops used in traditional medicine southeastern Mexico. studies on its biological properties have been conducted accessions harvested Conkal, Yucatan, Objectives this work, idea was to perform phytochemical analysis methanolic extracts B. orellana. Materials and Methods Phytochemical screening performed leaves seeds from two orellana, as...
Among the biological targets extensively investigated to improve inflammation and chronic inflammatory conditions, cyclooxygenase enzymes (COXs) occupy a prominent position. The inhibition of these enzymes, essential for mitigating processes, is chiefly achieved through Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). In this work, we introduce novel method-based on computational molecular docking-that could aid in structure-based design new compounds or description anti-inflammatory activity...
The synthesis, acid-base behavior, and Cu(2+) coordination chemistry of a new ligand (L1) consisting an azamacrocyclic core appended with lateral chain containing 3-hydroxy-2-methyl-4(1H)-pyridinone group have been studied by potentiometry, cyclic voltammetry, NMR UV-vis spectroscopy. studies showed that phenolate was protonated at the highest pH values [log K = 9.72(1)]. Potentiometric point out formation complexes 1:2, 2:2, 4:3, 1:1, 2:1 Cu(2+)/L1 stoichiometries. analysis electrochemical...
La medicina tradicional y estudios realizados a diferentes especies del género Prosopis, desierto sonorense, indican que es una fuente para la cualificación de compuestos bioactivos, con poder antioxidante ácidos grasos (linoleico linolénico) semilla. actividad biológica, atribuible alcaloides, flavonoides, terpenos fenólicos, lo cual, se realizó el perfil fitoquímico en los extractos acuoso, etanólico, hexanico clorofórmico (mediante técnicas colorimétricas), (método:...
A series of bis-N-substituted tetrandrine derivatives carrying different aromatic substituents attached to both nitrogen atoms the natural alkaloid were studied with double-stranded model DNAs (dsDNAs) examine binding properties and mechanism. Variable-temperature molecular recognition studies using UV-vis fluorescence techniques revealed thermodynamic parameters, ΔH, ΔS, ΔG, showing that exhibit high affinity toward dsDNA (K ≈ 105-107 M-1), particularly bis(methyl)anthraquinone (BAqT)...
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Antecedentes y Objetivos: Parkinsonia praecox,“palo brea”, es una planta medicinal distribuida en el Desierto de Sonora México. Sin embargo, existe poca información acerca la composición química del potencial biológico esta planta. Basado lo anterior, objetivo presente estudio fue determinar antioxidante antiproliferativo P. praecox. Métodos: Se prepararon extractos metanólicos tallos (PPS), frutos (PPB) flores (PPF). La se determinó a través los métodos perfil fitoquímico, Folin-Ciocalteu...