A5080494623- Subterranean biodiversity and taxonomy
- Environmental Toxicology and Ecotoxicology
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Fish biology, ecology, and behavior
- Marine Ecology and Invasive Species
- Animal Behavior and Reproduction
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- Recycling and Waste Management Techniques
- Microplastics and Plastic Pollution
- Fish Ecology and Management Studies
- Amphibian and Reptile Biology
- Lymphoma Diagnosis and Treatment
- Diverse Approaches in Healthcare and Education Studies
- Toxic Organic Pollutants Impact
- Ocean Acidification Effects and Responses
- Pharmaceutical and Antibiotic Environmental Impacts
- Oil Spill Detection and Mitigation
- Neurobiology and Insect Physiology Research
- Coral and Marine Ecosystems Studies
- Aquatic Invertebrate Ecology and Behavior
- Radiopharmaceutical Chemistry and Applications
- Environmental DNA in Biodiversity Studies
- Marine Bivalve and Aquaculture Studies
University of Minnesota
2020-2025
University of New Hampshire
2023-2025
University of California, Davis
2013-2024
Computational Physics (United States)
2022
St. Cloud State University
2011
Minnesota State University Moorhead
2007
Abstract The ubiquity of anthropogenic debris in hundreds species wildlife and the toxicity chemicals associated with it has begun to raise concerns regarding presence seafood. We assessed fishes shellfish on sale for human consumption. sampled from markets Makassar, Indonesia California, USA. All fish were identified where possible. Anthropogenic was extracted digestive tracts whole using a 10% KOH solution quantified under dissecting microscope. In Indonesia, found 28% individual 55% all...
The Deepwater Horizon oil rig disaster resulted in crude contamination along the Gulf coast sensitive estuaries. Toxicity from exposure to can affect populations of fish that live or breed oiled habitats as seen following Exxon Valdez spill. In an ongoing study effects on fish, killifish (Fundulus grandis) were collected site (Grande Terre, LA) and two reference locations (coastal MS AL) monitored for measures oil. Killifish Grande Terre had divergent gene expression liver gill tissue...
Identifying the genetic factors that underlie complex traits is central to understanding mechanistic underpinnings of evolution. Cave-dwelling Astyanax mexicanus populations are well adapted subterranean life and many appear have evolved troglomorphic independently, while surface-dwelling can be used as a proxy for ancestral form. Here we present high-resolution, chromosome-level surface fish genome, enabling first genome-wide comparison between cavefish populations. Using this resource,...
Environmental DNA (eDNA) is revolutionizing how we investigate biodiversity in aquatic and terrestrial environments. It increasingly used for detecting rare invasive species, assessing loss monitoring fish communities, as it considered a cost-effective noninvasive approach. Some environments, however, can be challenging eDNA analyses. Estuarine systems are highly productive, complex but samples collected from these settings may exhibit PCR inhibition low read recovery. Here present an...
Abstract Loss-of-function alleles are a pertinent source of genetic variation with the potential to contribute adaptation. Cave-adapted organisms exhibit striking loss ancestral traits such as eyes and pigment, suggesting that loss-of-function may play an outsized role in these systems. Here, we leverage 141 whole genome sequences evaluate evolutionary history adaptive single nucleotide premature termination codons (PTCs) Mexican tetra. We find cave populations contain significantly more...
The Astyanax mexicanus complex includes two different morphs, a surface- and cave-adapted ecotype, found at three mountain ranges in Northeastern Mexico: Sierra de El Abra, Guatemala la Colmena (Micos). Since their discovery, multiple studies have attempted to characterize the timing number of events that gave rise evolution these ecotypes. Here, using RADseq genome-wide sequencing, we assessed phylogenetic relationships, genetic structure gene flow between cave surface populations, estimate...
Abstract Androgen receptor (AR) inhibition is standard of care for advanced prostate cancer (PC). However, efficacy limited by progression to castration-resistant PC (CRPC), usually due AR re-activation via mechanisms that include amplification and structural rearrangement. These two classes alterations often co-occur in CRPC tumors, but it unclear whether this reflects intercellular or intracellular heterogeneity AR. Resolving important developing new therapies predictive biomarkers. Here,...
Abstract The genetic architecture of phenotypic traits can affect the mode and tempo trait evolution. Human‐altered environments impose strong natural selection, where successful evolutionary adaptation requires swift large shifts. In these scenarios, theory predicts that is due to a few adaptive variants effect, but empirical studies have revealed rapidly evolved phenotypes are rare, especially for populations inhabiting polluted environments. Fundulus killifish repeatedly resistance...
Abstract Patients with hormone receptor-positive (HR+) breast cancers frequently recur metastatic disease 5-20 years after initial diagnosis and completion of chemotherapy prolonged hormonal therapy treatment. A potential mechanism resistance in HR+ patients is the presence slow dividing or dormant well-differentiated cancer cells that result clinically detectable metastases a latency. One way to eliminate these immunotherapy. The objective this study target using natural killer (NK) cell...
This paper introduces a new bio-assessment tool, the mini-mobile environmental monitoring unit (MMU). The MMU is portable, lightweight, energy-efficient, miniaturized laboratory that provides low-flow system for on-site exposure of aquatic animals to local receiving waters in protected, controllable environment. Prototypes were tested twice week-long studies conducted during summers 2008 and 2009, 12-day study 2010. In 2008, fathead minnows polar organic chemical integrative samplers (POCIS)...
Abstract Killifish (Fundulus heteroclitus) are widely distributed among different aquatic environments where they demonstrate an impressive range of highly-plastic and locally adaptive phenotypes. High-throughput sequencing has begun to unravel the mechanisms evolutionary history these interesting features by establishing relationships in genotype-phenotype map. However, some analyses require a higher order contiguity than what initial scaffolded (fragmented genome assembly contigs have been...
Ocean acidification is expected to degrade marine ecosystems, yet most studies focus on organismal-level impacts rather than ecological perturbations. Field are especially sparse, particularly ones examining shifts in direct and indirect consumer interactions. Here we address such connections within tidepool communities of rocky shores, focusing a three-level food web involving the keystone sea star predator,
Pairs of species that exhibit broadly overlapping distributions, and multiple geographically isolated contact zones, provide opportunities to investigate the mechanisms reproductive isolation. Such naturally replicated systems have demonstrated hybridization rates can vary substantially among populations, raising important questions about genetic basis The topminnows,
Abstract Identifying the genetic factors that underlie complex traits is central to understanding mechanistic underpinnings of evolution. In nature, adaptation severe environmental change, such as encountered following colonization caves, has dramatically altered genomes species over varied time spans. Genomic sequencing approaches have identified mutations associated with troglomorphic trait evolution, but functional impacts these remain poorly understood. The Mexican Tetra, Astyanax...
Hospitals in the West of Scotland are to be surveyed as a first step what may become an all-Scottish hospital census that will provide background collated information for any projected scheme reorganization after war.The surveyors, appointed by Secretary State Scotland, two Glasgo,W University professors-Prof.J. M. Mackintosh (Chair Public Health) and Prof. C. F. W. Iilingworth Surgery)-together with Senior Deputy Medical Officer Health Glasgow (Dr.R. J
<h3>Background</h3> HCW9218 is a bifunctional protein complex comprising dimeric extracellular domains of the human transforming growth factor beta (TGF-β) receptor II and interleukin-15 (IL-15). acts to (1) stimulate immune effector cells (2) sequester soluble immunosuppressive TGF-β.<sup>1, 2</sup> The primary objective this Phase I first-in-human clinical trial determine maximum tolerated dose in advanced solid tumors. <h3>Methods</h3> administered subcutaneously outpatient setting once...
The genetic architecture of phenotypic traits can affect the mode and tempo trait evolution. Human-altered environments impose strong natural selection, where successful evolutionary adaptation requires swift large shifts. In these scenarios, theory predicts influence few adaptive variants effect, but empirical studies that have revealed rapidly evolved phenotypes are rare, especially for populations inhabiting polluted environments.
Abstract Inhibition of the androgen receptor (AR) transcription factor is mainstay therapeutic strategy for systemic prostate cancer. However, development a resistance phenotype termed castration resistant cancer (CRPC) enables disease progression that underlies virtually all mortality. In majority CRPC, AR transcriptionally re-activated in part due to accumulation numerous alterations gene. These genomic include missense mutations exons encode ligand binding domain AR, amplification gene...
Abstract Androgen deprivation therapies are employed for the treatment of advanced prostate cancer to suppress transcriptional activity androgen receptor (AR). However, over course therapy, AR re-emerges, and disease progresses castration resistant (CRPC). During CRPC progression, becomes heavily altered by genomic aberrations that include amplification, missense mutations, structural variants (SVs). SVs heterogeneous across specimens, with variability noted in SV class, breakpoint...
<h3>Background</h3> Natural killer (NK) cell effector function is suppressed in the tumor microenvironment (TME) of metastatic castration-resistant prostate cancer (mCRPC), lethal form cancer. This largely due to inherently 'cold' nature TME mCRPC that immunosuppressive, hypoxic and lacks cytolytic lymphocyte infiltration. To improve NK anti-tumor responses against TME, we designed a novel tri-specific engager (TriKE®) molecule consists three parts: an arm engages with CD16, activating...