A5100694067- Subterranean biodiversity and taxonomy
- Marine Ecology and Invasive Species
- Ichthyology and Marine Biology
- Developmental Biology and Gene Regulation
- Cancer, Lipids, and Metabolism
- Connexins and lens biology
- Animal Genetics and Reproduction
- Remote Sensing and LiDAR Applications
- Turtle Biology and Conservation
- Mercury impact and mitigation studies
- Land Use and Ecosystem Services
- Pluripotent Stem Cells Research
- Remote-Sensing Image Classification
- Retinal Development and Disorders
- Renal cell carcinoma treatment
- Venomous Animal Envenomation and Studies
- Genomics and Phylogenetic Studies
- Heat shock proteins research
- Landslides and related hazards
- Intraocular Surgery and Lenses
- Extracellular vesicles in disease
- Physiological and biochemical adaptations
- Marine animal studies overview
- Atmospheric and Environmental Gas Dynamics
- Synthetic Aperture Radar (SAR) Applications and Techniques
Osaka University
2024-2025
University College London
2007-2023
Aichi Institute of Technology
2011-2013
University of Maryland, College Park
2000-2009
Civil Engineering Research Institute for Cold Region
2003-2006
The University of Tokyo
2004
College of Industrial Technology
2002
Osaka City University
2000
Kumamoto University
1994-1998
Kumamoto Health Science University
1994
Astyanax mexicanus is a teleost with eyed surface-dwelling and eyeless cave-dwelling forms. Eye formation initiated in cave fish embryos, but the eye subsequently arrests degenerates. The surface lens stimulates growth development after transplantation into optic cup, restoring tissues lost during evolution. Conversely, are retarded following of cup or extirpation. These results show that evolutionary changes an inductive signal from involved degeneration.
How and why animals lose eyesight during adaptation to the dark food-limited cave environment has puzzled biologists since time of Darwin. More recently, several different adaptive hypotheses have been proposed explain eye degeneration based on studies in teleost Astyanax mexicanus, which consists blind cave-dwelling (cavefish) sighted surface-dwelling (surface fish) forms. One these is that regression result indirect selection for constructive characters are negatively linked development...
Although Astyanax mexicanus surface fish regenerate their hearts after injury, Pachón cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. Myocardial proliferation peaks at levels in both and 1 week injury. However, Pachón, this peak coincides with strong scarring immune response, ultimately, cavefish cardiomyocytes fail replace scar. We identified lrrc10 be upregulated compared Similar cavefish, knockout of zebrafish impairs heart...
Identifying the genetic factors that underlie complex traits is central to understanding mechanistic underpinnings of evolution. Cave-dwelling Astyanax mexicanus populations are well adapted subterranean life and many appear have evolved troglomorphic independently, while surface-dwelling can be used as a proxy for ancestral form. Here we present high-resolution, chromosome-level surface fish genome, enabling first genome-wide comparison between cavefish populations. Using this resource,...
Bacterial flora are present in various parts of the human body, including intestine, and thought to be involved etiology diseases such as multiple sclerosis, intestinal diseases, cancer, uterine diseases. In recent years, presence bacterial 16S rRNA genes has been revealed blood, which was previously a sterile environment, characteristic blood microbiomes have detected However, mechanism origin information unknown. this study, we performed metagenomic analysis DNA serum extracellular...
Abstract Background Circulating tumor DNA (ctDNA) is a promising tool for diagnosing and predicting cancer prognosis. However, its clinical utility in metastatic renal cell carcinoma (mRCC) remains unclear, particularly terms of Methods We enrolled 124 patients with mRCC the MONSTAR-SCREEN study (UMIN 000036749) between August 2019 February 2022, national observational ctDNA-based screening study, performed ctDNA sequencing before at time resistance to systemic therapy. Results were assessed...
Summary We studied the development and evolution of craniofacial features in teleost fish, Astyanax mexicanus . This species has an eyed surface dwelling form (surface fish) many different cave forms (cavefish) with various degrees reduced eyes pigmentation. The we examined are tooth‐bearing maxillary bones, nasal antorbital circumorbital opercular all which show evolutionary modifications cavefish populations. Manipulations eye formation by transplantation embryonic lens, lentectomy, or...
The activities of 228 Ra and 226 in the seawaters eastern Indian Ocean its adjacent seas were measured during 1996/1997 “Piscis Austrinus” Expedition using R/V Hakuho‐Maru . surface data are good agreement with those literature indicate that continental shelves southeast Asian Seas strong sources for and, to much lesser extent, which largely transported by currents into Ocean. vertical profiles obtained at six stations from different oceanic regimes along cruise track generally showed an...
We used the teleost <i>Astyanax</i><i>mexicanus</i> to examine role of lens in optic nerve and tectum development. This speciesis unusually suited for studies nervous system development evolution because its two extant forms: an eyed surface dwelling (surface fish) several blind cave (cavefish) forms. Cavefish embryos initially form eye primordia, but eventually dies by apoptosis, then retina ceases grow, finally degenerating eyes sink into orbits. Transplantation...
The evolutionary mechanisms responsible for the loss of eyes in cave animals are still unresolved. Hypotheses invoking natural selection or neutral mutation have been advanced to explain eye regression. Here we describe comparative molecular and developmental studies teleost Astyanax mexicanus that shed new light on this problem. A. is a single species consisting sighted surface-dwelling form (surface fish) many blind cave-dwelling forms (cavefish) from different caves. We first review...
Lens apoptosis plays a central role in cavefish eye degeneration. Heat shock proteins (hsps) can regulate apoptosis; therefore, we examined the relationship between constitutive hsp70 and hsp90 expression lens apoptosis. The model system is Astyanax mexicanus, teleost species consisting of an eyed surface-dwelling (surface fish) form numerous blind cave-dwelling (cavefish) forms. Optic primordia are formed embryo but they subsequently undergo apoptosis, arrest development degenerate. DNAs...
Combination therapy with immune checkpoint inhibitors has become the standard first-line treatment for metastatic renal cell carcinoma (mRCC), leading to changes in second-line options, such as nivolumab or tyrosine kinase (TKIs). However, very few studies have compared efficacy of these drugs patients mRCC, particularly those bone metastases (BM), which are associated a poor prognosis. This study and TKIs treatments mRCC BM examined microenvironments primary tumors lesions....
Teleost fishes display a remarkable diversity of adult dentitions; this is all the more in light uniformity first-generation dentitions. Few studies have quantitatively documented transition between generalized dentitions and specialized teleosts. We investigated Mexican tetra, Astyanax mexicanus (Characidae), by measuring aspects dentition an ontogenetic series individuals from embryos to 160 days old, addition adults unknown age. The its immediate successors consist small, unicuspid teeth...