A5041270925- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Research and Treatments
- Iron Metabolism and Disorders
- Pancreatic and Hepatic Oncology Research
- Zebrafish Biomedical Research Applications
- Trace Elements in Health
- Nanoparticles: synthesis and applications
- Pancreatic function and diabetes
- FOXO transcription factor regulation
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Adrenal Hormones and Disorders
- Autophagy in Disease and Therapy
- Ovarian cancer diagnosis and treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Tracheal and airway disorders
- Tannin, Tannase and Anticancer Activities
- MicroRNA in disease regulation
- Kidney Stones and Urolithiasis Treatments
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
Pusan National University
2016-2025
Institute for Basic Science
2019-2022
Inje University
2022
Asan Medical Center
2005
University of Ulsan
2005
Ulsan College
2005
Catholic University of Korea
1998
GLUT2 (SLC2A2), a vital glucose transporter in liver, pancreas, and kidney tissues, regulates blood levels energy metabolism. Beyond its metabolic role, SLC2A2 contributes to cell differentiation adaptation during embryogenesis tissue regeneration. Despite significance, the role of liver hepatocellular carcinoma (HCC) remains underexplored. This study investigated SLC2A2’s using silico, vitro, vivo approaches. Analysis GEO datasets (GSE132606, GSE25417, GSE67848) TCGA HCC data revealed that...
Accurate prediction of malignancies is important in choosing therapeutic strategies. Although there are many genetic and cytogenetic prognostic factors for acute myeloid leukemia (AML), prognosis difficult to predict because the heterogeneity AML. Prognostic factors, including messenger RNA (mRNA) expression, have been determined other malignancies, but not A total 402 patients from The Cancer Genome Atlas, GSE12417 (GPL96, 97), (GPL570) were included this study. In Kaplan-Meier curve...
Abstract Acute myeloid leukaemia (AML) is a blood cancer where undifferentiated cells are increased in the bone marrow and peripheral blood. As AML dangerous shows poor prognosis, many researchers categorised relevant cytogenetic factors according to risk prognosis. However, specific reasons for remain unknown. We analysed large data set from patients found that TPD52 expression elevated patient groups with factors. amino acid sequence of evolutionally conserved vertebrates, zebrafish...
Colorectal cancer (CRC) as an environmental disease is largely influenced by accumulated epithelial stress from diverse causes. We are exposed to ribosome-related insults, including ribosome-inactivating (RIS), the environment, dietary factors, and medicines, but their physiological impacts on chemotherapy of CRC not yet understood. Here we revealed effects RIS chemosensitivity other malignancy-related properties cells. First, led bidirectional inhibition p53-macrophage inhibitory cytokine 1...
<i>Objective:</i> X-linked adrenal hypoplasia congenita (AHC) is a condition clinically featuring insufficiency and hypogonadotropic hypogonadism caused by mutations of <i>DAX-1</i>. This study was undertaken to characterize the molecular defects <i>DAX-1</i> in 3 unrelated Korean patients with AHC. <i>Patients Methods:</i> Patient 1 6-year-old boy who presented salt-losing crisis neonatal period. 2 3-year-old manifested aspiration pneumonia at...
Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In present study, using databases such as TARGET, GSE60926 GSE28460, we determined that KIF2C its binding partner, KIF18B are overexpressed in patients with relapsed compared to diagnosed first time. As 50% residues exactly same signature domain highly conserved between human zebrafish, used zebrafish embryos a model...
With the growing requirement for novel prognostic biomarkers pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although been performed, carbohydrate antigen 19-9 is only biomarker in use. Therefore, present study examined whether γ-secretase genes, including presenilin (PSEN), nicastrin (NCSTN), enhancer protein 2 (PSENEN), and anterior pharynx-defective 1 (APH1-), could serve as factors cancer. The cohorts selected included >100 cancer patients. Patient data...
Abstract Cobll1 affects blast crisis (BC) progression and tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML). PACSIN2, a novel binding protein, activates TKI‐induced apoptosis K562 cells, this activation is suppressed by through the interaction between PACSIN2 Cobll1. also binds inhibits SH3BP1 which downstream Rac1 pathway induces TKI resistance. competitively interacts with or higher affinity for preferentially to releasing promote SH3BP1/Rac1 suppress...
Iron transfer across the basolateral membrane of an enterocyte into circulation is rate-limiting step in iron absorption and regulated by various pathophysiological factors. Ferroportin (FPN), only known mammalian exporter, transports from surface enterocytes, macrophages, hepatocytes blood. Patients with genetic mutations FPN or repeated blood transfusion develop hemochromatosis. In this study, non-mutagenic ribosomal inactivation was assessed as etiological factor FPN-associated...
Background/Aim: Since pathways involving LRRC17 are related to the survival of patients with various cancers, we analyzed as a prognostic gene in serous ovarian cancer. Materials and Methods: Data were collected from Gene Expression Omnibus (GSE9891, GSE13876, GSE26712) The Cancer Genome Atlas (TCGA). We performed analyses using C statistics, area under curve, plot optimal cutoff level, cox proportional regression. Zebrafish embryos used an vivo model. Results: prognosis high expression was...