A5107424288- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Organophosphorus compounds synthesis
- Sulfur-Based Synthesis Techniques
- Boron Compounds in Chemistry
- Organometallic Complex Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Click Chemistry and Applications
- Organoboron and organosilicon chemistry
Tianjin University
2018-2020
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2020
National University of Singapore
2020
Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction alkyl 3-aminoacrylates with aryldiazonium salts, both which readily available substrates. Furthermore, 2-aminoacrylates also viable Diverse and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike...
A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters H-phosphites is described. This C(sp2)–H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained grams added new modules to the toolkit for peptide modifications.
Abstract Organophosphorus compounds are essential structures in modern pharmaceutical, agrochemical, and material sciences. The development of new efficient methods for the synthesis C–P bonds has been an important focus research. We herein report a Pd‐catalyzed enamido C(sp 2 )–H phosphorylation direct construction under simple convenient conditions without need additional ligands or directing groups. present reaction can tolerate wide range functional groups, furnish variety products...
Herein we report a novel and straightforward protocol for the construction of valuable gem-BPs by means proton-coupled electron-transfer (PCET)-triggered enamido C(sp2 )-H diphosphorylation. This reaction represents rare example realizing challenging double C-P bond formation at single carbon atom, thus providing facile access to broad variety structurally diverse bisphosphonates from simple enamides under silver-mediated conditions. Initial mechanistic studies demonstrated that...