A5055212678- Inflammatory Bowel Disease
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Diagnosis and treatment of tuberculosis
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders Research
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Gastric Cancer Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Tuberculosis Research and Epidemiology
- Ocular Diseases and Behçet’s Syndrome
- Mesenchymal stem cell research
- Mycobacterium research and diagnosis
- Inflammatory Biomarkers in Disease Prognosis
Sun Yat-sen University
2016-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2010-2019
University of Pittsburgh
2019
Cheng Ching Hospital
2019
Guangzhou University
2019
Queen Elizabeth Hospital
2005
The University of Adelaide
2005
The IL23/Th17 pathway is essential for the onset of inflammatory bowel disease (IBD), yet specific mechanism by which this initiates remains unknown. In study, we identify mechanisms that mediate cross-talk between IL23 and intestinal barrier in IBD. downstream targets were identified RNA array profiling confirmed immunohistochemical staining. role miRNAs interact with was explored mice TNBS-induced colitis. Claudin-8 (CLDN8), a multigene family protein constitutes backbone tight junctions,...
Summary Background Thiopurine‐induced leukopenia is the most common dangerous adverse event in Asians. NUDT 15 R139C was recently proposed to be a promising biomarker for with thiopurine therapy Asians, but this has not been replicated Chinese population. Aim To investigate influence of R139C, S‐methyltransferase ( TPMT ), 6‐ TGN and MMPR on thiopurine‐induced patients Crohn's disease. Methods Clinical epidemiological characteristics were reviewed from medical records. genotyped. /6‐...
Abstract Background Mesenchymal stem cells (MSC) have shown promising potential for treating inflammatory bowel disease (IBD). The interactions between fibroblasts and epithelial play a crucial role in initiating the intestinal mucosal repair process. This study explored whether MSC therapy promoted via regulating fibroblast-epithelial interactions. Methods MSCs were isolated from human umbilical cord tissue. (2x106 cells/mouse) injected intraperitoneally into mice treated with dextran...
Background The gut microbiome and diet are important factors in the pathogenesis management of Crohn’s disease (CD). However, role phageome under dietary influences is unknown. Objective We aim to explore effect on phageome-bacteriome interaction linking CD protection. Design recruited patients healthy subjects (n=140) conducted a multiomics investigation, including paired ileal mucosa bacteriome profiling, survey phenome interrogation. screened for bacteriome, as well its epidemiological...
NUDT15 c.415C>T was a novel genetic marker confirmed in our center for thiopurine-induced leukopenia Chinese inflammatory bowel disease (IBD). For validation, large cohort study is needed. Meanwhile, the newly discovered coding variants (c.36_37insGGAGTC and c.52 G>A) have not been studied patients with IBD. We aimed to further confirm influence of 3 (c.415C>T, c.36_37insGGAGTC, c.52G>A) on Patients prescribed thiopurines at least 2 weeks were recruited from 4 tertiary hospitals. Clinical...
Specific members of the RING finger [RNF] protein family serve as E3 ubiquitin ligases and play important roles in regulation inflammation. However, their pathogenesis inflammatory bowel disease [IBD] have not been explored.Genomic microarray inflamed colon samples from Crohn's [CD] patients was performed to identify potential up-regulated genes. Expression identified highly RNF183 gene subsequently examined by quantitative reverse transcription polymerase chain reaction [qRT-PCR], western...
Identification of new biomarkers may help in the early diagnosis inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze untargeted lipidomics and compare plasma lipid profiles between IBD patients control subjects. The principal component analysis partial least-squares-discriminant were carried out distinguish from Using univariate multivariate analysis, 55...
Abstract Background To clarify the effect of human umbilical cord-derived mesenchymal stem cell (hUC-MSCs) treatment on colitis and to explore role CD5 + B cells in MSC therapy. Methods The trinitrobenzenesulfonic acid (TNBS)-induced mouse model was used. HUC-MSCs were transferred peritoneally. Survival rates, symptoms, macroscopic histologic scores evaluated. CD4 T helper (Th) subgroups regulatory (Bregs) lymphocytes quantitated by flow cytometry. Cytokine levels detected ELISA Bio-plex....
Summary Background Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. Aims To determine whether circulating microRNAs biomarkers IBD monitoring. Methods Serum levels 17 candidate were measured by quantitative real‐time polymerase chain reaction in a discovery cohort (n = 120). Differentially expressed serum further investigated an independent training 341). Correlations between relative microRNA activity...
Ustekinumab and vedolizumab are both effective for treating Crohn's disease (CD). However, no head-to-head trials have been conducted thus far. We aimed to compare the effectiveness of ustekinumab in CD patients either naïve or exposed tumor necrosis factor-alpha inhibitors (TNFi).Patients treated with luminal were included from six centers China May 2020 July 2023. Steroid-free remission, clinical objective response, remission at Weeks 26 52 evaluated a retrospective multicenter propensity...
The CD4(+) T-cell subgroups play central pathophysiological roles in Crohn's disease (CD); however, their clinical relevance requires additional clarification and remains controversial. We investigated balance Chinese CD patients explored significance.Peripheral blood mononuclear cells serum were collected from 46 23 healthy donors. Circulating Treg, Th1, Th2, Th17 flow cytometrically analyzed. Subgroup-restricted transcription factor expression was determined by real-time polymerase chain...
Thiopurine-induced leucopenia significantly hinders the wide application of thiopurines. Dose optimization guided by nudix hydrolase 15 (
AIM:To investigate the relationship between Apolipoprotein C3 (APOC3 ) (-455T>C) polymorphism and nonalcoholic fatty liver disease (NAFLD) in Southern Chinese han population. METHODS:In this prospective case-control study, we recruited 300 NAFLD patients healthy controls to a cohort representing population at The First Affiliated Hospital, Sun Yat-sen University, from January December 2012.Polymerase chain reaction-restriction fragment length DNA sequencing were used genotype APOC3 variants....
Cytokine interleukin-9 (IL9) plays an essential role in the pathogenesis of inflammatory bowel disease. However, molecular mechanism underlying IL9 pathway remains unknown. Here, we initiate a series studies to characterize components this pathway.The expression colon biopsies from Crohn's disease (CD) and controls were examined by quantitative polymerase chain reaction, immunoblot, immunohistochemistry. The trinitrobenzene sulfonic acid (TNBS)-induced colitis model was used verify...
This cross-sectional study investigated the prevalence and risk factors of high-risk human papilloma virus (HPV) infection, especially types 16 18, cervical neoplasia in female Inflammatory bowel disease (IBD) patients.From July 2014 to January 2017, sexually active, female, Chinese IBD patients (21-60 years) age-matched controls underwent ThinPrep cytology testing (TCT) HPV-DNA detection, completed questionnaires about awareness cancer HPV. Cervical dysplasia was categorized as...
Endoscopic healing (EH) is a key therapeutic target in Crohn's disease (CD). Proximal small bowel (SB) lesions patients with CD are associated significant risk of strictures and resection. Assessing SB necessary because its implications. The advent biologic therapies, including infliximab, ustekinumab, vedolizumab, has significantly altered treatment. However, data on the efficacy biologics achieving EH, specifically proximal CD, remain limited. To assess effectiveness for EH jejunal and/or...
Abstract Background Ustekinumab (UST) has been proved to be effective in the treatment of Crohn's disease (CD). However, data on efficacy UST treating CD patients with penetrating complications are limited. The objective this study was evaluate and safety CD. Methods In single-center, prospective, observational real-world study, we enrolled who were undergoing treatment. primary endpoint rate transmural healing at week 26 52 evaluated by computerized tomography enterography or magnetic...
Vedolizumab (VDZ), a humanized monoclonal antibody that selectively inhibits the binding of α4β7 integrin, has been approved for treating inflammatory bowel disease (IBD). Long-term safety studies VDZ in clinical trials identified Clostridium difficile infection (CDI) as major opportunistic infection. We aimed to address incidence and risk factors C. colonization (CDC) CDI real-world setting among IBD patients treated with VDZ. Retrospective multicenter study. retrospectively included who...