A5059011290- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Global Cancer Incidence and Screening
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Endometriosis Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Uterine Myomas and Treatments
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Reproductive Health and Contraception
- Electrolyte and hormonal disorders
- Ear Surgery and Otitis Media
- Cancer Diagnosis and Treatment
- Liver Diseases and Immunity
- BRCA gene mutations in cancer
- Cardiac, Anesthesia and Surgical Outcomes
Piedmont Reference Center for Epidemiology and Cancer Prevention
2017-2024
Karolinska Institutet
2024
Istituto per lo Studio e la Prevenzione Oncologica
2022
Istituto Oncologico Romagnolo
2013-2020
International Society for Prosthetics and Orthotics
2013
Ospedale del Ceppo
2009-2012
University of Florence
2004-2009
<h3>Background</h3> ITALUNG is contributing to the European evaluation of low-dose CT (LDCT) screening for lung cancer (LC). <h3>Methods</h3> Eligible subjects aged 55–69 years, smokers or ex-smokers (at least 20 pack-years in last 10 years), were randomised receive an annual invitation LDCT 4 years (active group) usual care (control group). All participants followed up vital status and cause death end 2014) LC incidence 2013). Pathological clinical information was collected from Tuscan...
One of the most important problems in segmentation lung nodules CT imaging arises from possible attachments occurring between and other structures, such as vessels or pleura. In this report, we address problem by proposing an automated correction method applied to initial rough nodule. The is based on a local shape analysis making use 3-D geodesic distance map representations. has advantage that it locally refines nodule along recognized vessel only, without modifying boundary elsewhere. was...
Computed tomography (CT) is the most sensitive imaging technique for detecting lung nodules, and now being evaluated as a screening tool cancer in several large samples studies all over world. In this report, we describe semiautomatic method 3-D segmentation of nodules CT images subsequent volume assessment. The distinguishing features our algorithm are following. 1) user interaction process. It allows introduction knowledge expert simple reproducible manner. 2) adoption geodesic distance...
Changes in smoking habits and predictors of cessation were examined the randomized ITALUNG lung cancer screening trial.In three centers, eligible smokers or ex-smokers (55-69 years, ≥20 pack-years last 10 years) to receive annual invitation for low-dose computed tomography 4 years usual care. At invitation, subjects received written information a free program. Quitting outcome was assessed at year 4.Among participants who completed baseline assessments screening, higher quitting (20.8% vs....
Smoking is the main risk factor for lung cancer (LC), which leading cause of cancer-related death worldwide. Independent randomized controlled trials, governmental and inter-governmental task forces, meta-analyses established that LC screening (LCS) with chest low dose computed tomography (LDCT) decreases mortality in smokers former smokers, compared to no-screening, especially women. Accordingly, several Italian initiatives are offering LCS by LDCT smoking cessation about 10,000 high-risk...
Few data are available on the effective dose received by participants in lung cancer screening programmes with low-dose CT (LDCT). We report collective delivered to 1406 current or former smokers enrolled ITALUNG trial who completed 4 annual LDCT examinations and related further investigations including follow-up LDCT, 2-[(18)F]flu-2-deoxy-d-glucose positron emission tomography (FDG-PET) CT-guided fine needle aspiration biopsy (FNAB). Using air index Monte Carlo simulations an...
Risk-Benefit Analysis of X-Ray Exposure Associated with Lung Cancer Screening in the Italung-CT TrialMario Mascalchi1, Giacomo Belli2, Marco Zappa3, Giulia Picozzi1, Massimo Falchini1, Riccardo Della Nave1, Germana Allescia1, Andrea Masi4, Lopes Pegna5, Natale Villari1 and Eugenio Paci3Audio Available | Share
Asymptomatic high-risk subjects, randomized in the intervention arm of ITALUNG trial (1,406 screened for lung cancer), were enrolled biomarker study (n = 1,356), which samples blood and sputum analyzed plasma DNA quantification (cut off 5 ng/ml), loss heterozygosity microsatellite instability. The panel (IBP) was considered positive if at least one two biomarkers included positive. Subjects with without cancer diagnosis end screening cycle LDCT 517) evaluated. Out 18 baseline screen detected...
Cardiovascular disease (CVD), lung cancer (LC), and respiratory diseases are main causes of death in smokers former undergoing low-dose computed tomography (LDCT) for LC screening. We assessed whether quantification pulmonary emphysematous changes at baseline LDCT has a predictive value concerning long-term mortality.In this longitudinal study, we with densitometry (volume corrected relative area below - 950 Hounsfield units) coronary artery calcifications (CAC) 0-3 visual scale 524...
Abstract Introduction: Low-dose computed tomography (LDCT) screening can reduce lung cancer (LC)-related mortality, but questions remain about the duration of this effect and differences by sex tumor histology. Methods: Extended follow-up data from ITALUNG LUSI trials were pooled to examine screening-related stage-shifts estimate relative hazards for LC-related Findings compared to, additionally combined with, those US National Lung Screening Trial (NLST). Results: In ITALUNG-LUSI, yielded a...
Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC subjects recruited the ITALUNG randomized clinical trial. Cases cytologically/histologically proven detected at LDCT or follow-up CT were selected and pathologically re-evaluated according to WHO 2015 classification. Overall 16 diagnosed (n=14, all present baseline) (n=2) six (4 one subject, 3 two 2 three subjects),...
Abstract The aim of this study was to explore biological interaction and pathophysiology mechanisms in a new mouse model cardiovascular–kidney–metabolic (CKM) syndrome, induced by chronic moderate renal failure combination with consumption customized Western diet rich carbohydrates, fat salt. Male C57BL/6J mice were subjected unilateral nephrectomy, fed not only sugar but also salt, followed for 12 weeks or 20 weeks. Sham-operated on standard chow served as healthy controls. Body...
Routine neonatal circumcision—the non-therapeutic circumcision of infant males—has generated considerable ethical controversy. In this article, I suggest that much the disagreement results from conflicting ideas about autonomy child. examine two questions autonomy. First, ask whether we should be realists or idealists future autonomous choices child—that is, account for fact child may not make best in future, assume his will reflect interests. Second, has a right to with respect...
The role of total plasma cell-free DNA (cfDNA) in lung cancer (LC) screening with low-dose computed tomography (LDCT) is uncertain. We hypothesized that cfDNA could support differentiation between malignant and benign nodules observed LDCT. baseline was measured 137 subjects the ITALUNG trial, including 29 screen-detected LC (17 prevalent 12 incident) 108 nodules. predictive capability to differentiate compared Lung-RADS classification Brock score at initial LDCT (iLDCT). Subjects showed...