A5004371130- RNA and protein synthesis mechanisms
- RNA regulation and disease
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
Fujian Medical University
2023
eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual remain poorly defined. Using multiomic profiling upon acute depletion eIF3 subunits, we observed that while eIF3a, b, e, and f markedly differed their impact on holo-complex formation translation, they were each required for cancer cell proliferation tumor growth. Remarkably, eIF3k showed the opposite pattern with promoting global...
SUMMARY ∼30% of clear cell renal carcinoma (ccRCC) patients present with metastatic disease at the time diagnosis, causing a dire 5-year survival rate 13%. Whereas anti-PD-1 immunotherapy has improved survival, strong need remains for new therapeutic options. Using integrated network analysis, we identified mitotic regulator NDC80 as predictor ccRCC progression. Overexpression fosters malignant phenotype by promoting cycle progression through S phase well boosting glycolysis and...