A5068639178- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Nuclear Structure and Function
Northwestern University
2022-2023
Summary Many Lamin A-associated proteins (LAAP’s) that are key constituents of the nuclear envelope (NE), assemble at “core” domains chromosomes during NE reformation and mitotic exit. However, identity function chromosomal core remain ill-defined. Here, we show a distinct section domain overlaps with centromeres/kinetochores telophase. The can thus be demarcated into kinetochore proximal (KPC) on one side segregated distal (KDC) opposite side, close to central spindle. We next tested if...
ABSTRACT Mitotic kinetochores are initially captured by dynamic microtubules via a ‘search-and-capture’ mechanism. The microtubule motor, dynein, is critical for kinetochore capture as it has been shown to transport microtubule-attached chromosomes towards the spindle pole during early mitosis. In metaphase, localized, microtubule-binding complex, Ndc80, plays central role in stabilizing kinetochore-microtubule (kMT) attachments. It not yet clear, however, if which recruited very mitosis...
Mitotic kinetochores are initially captured by dynamic microtubules via a "search-and-capture" mechanism. The microtubule motor, dynein, is critical for kinetochore capture as it has been shown to transport microtubule-attached chromosomes toward the spindle pole during prometaphase. microtubule-binding nuclear division cycle 80 (Ndc80) complex that recruited in prophase known play central role forming kinetochore-microtubule (kMT) attachments metaphase. It not yet clear, however, how Ndc80...