Destiny Ariel Wallace

ORCID: 0000-0003-2367-9485
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About
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Research Areas
  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • Microtubule and mitosis dynamics
  • Photosynthetic Processes and Mechanisms
  • RNA Research and Splicing
  • Nuclear Structure and Function

Northwestern University
2022-2023

Summary Many Lamin A-associated proteins (LAAP’s) that are key constituents of the nuclear envelope (NE), assemble at “core” domains chromosomes during NE reformation and mitotic exit. However, identity function chromosomal core remain ill-defined. Here, we show a distinct section domain overlaps with centromeres/kinetochores telophase. The can thus be demarcated into kinetochore proximal (KPC) on one side segregated distal (KDC) opposite side, close to central spindle. We next tested if...

10.1101/2023.09.25.559341 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-09-26

ABSTRACT Mitotic kinetochores are initially captured by dynamic microtubules via a ‘search-and-capture’ mechanism. The microtubule motor, dynein, is critical for kinetochore capture as it has been shown to transport microtubule-attached chromosomes towards the spindle pole during early mitosis. In metaphase, localized, microtubule-binding complex, Ndc80, plays central role in stabilizing kinetochore-microtubule (kMT) attachments. It not yet clear, however, if which recruited very mitosis...

10.1101/2022.02.10.479964 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2022-02-10

Mitotic kinetochores are initially captured by dynamic microtubules via a "search-and-capture" mechanism. The microtubule motor, dynein, is critical for kinetochore capture as it has been shown to transport microtubule-attached chromosomes toward the spindle pole during prometaphase. microtubule-binding nuclear division cycle 80 (Ndc80) complex that recruited in prophase known play central role forming kinetochore-microtubule (kMT) attachments metaphase. It not yet clear, however, how Ndc80...

10.1016/j.jbc.2023.104711 article EN cc-by Journal of Biological Chemistry 2023-04-14
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