A5075941901- Magnesium Alloys: Properties and Applications
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Aluminum Alloys Composites Properties
- Advanced ceramic materials synthesis
- Medicinal Plant Pharmacodynamics Research
- Advanced materials and composites
- Hydrogen Storage and Materials
- Intermetallics and Advanced Alloy Properties
- Corrosion Behavior and Inhibition
- Wireless Power Transfer Systems
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Antimicrobial Peptides and Activities
- Microbial Natural Products and Biosynthesis
- Parathyroid Disorders and Treatments
- Additive Manufacturing Materials and Processes
- Advanced Welding Techniques Analysis
- Extracellular vesicles in disease
- Metallic Glasses and Amorphous Alloys
- Cell Adhesion Molecules Research
- Caveolin-1 and cellular processes
- E-commerce and Technology Innovations
- Cellular and Composite Structures
- Magnesium in Health and Disease
Shenzhen Institute of Information Technology
2021-2024
Shanghai East Hospital
2023
Peking University Shenzhen Hospital
2020-2022
Shanghai Jiao Tong University
2015-2021
University of Hong Kong - Shenzhen Hospital
2020-2021
Hong Kong University of Science and Technology
2020
Taiyuan University of Technology
2013
Inspired by the process of bone reconstruction, porous scaffolds with robust osteogenesis and biodegradability would provide an ideal substitute for clinical practice. In this study, a novel Mg–Nd–Zn–Zr (JDBM) alloy scaffold coated brushite (i.e., DCPD), denoted as JDBM-DCPD, is fabricated using special patent template technique, which forms main spherical pores (400–450 μm) smaller (150–250 interconnected between adjacent pores, facilitating nutrient penetration cell in-growth, exhibiting...
Bone tissue engineering is considered as a promising pathway for bone regeneration and defect reconstruction, in which scaffolds play an important role. Zn alloy, biodegradable metal material that has advantages of metallic characteristics, its special features, especially the ideal degradation rate acceptable biocompatibility, make it worthy to be further investigated medical applications. In this study, new porous alloy with Ca–P coating were attempted repair cranial defect, vitro vivo...
Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration, blood vessels invasion and transport nutrient waste. However, efforts understanding interconnectivity porous Mg limited due to diverse architectures pore struts size distribution systems. In this work, biomimetic hierarchical scaffolds with tailored as well were prepared by template replication infiltration casting. better showed lower mechanical strength. Enlarging interconnected pores...
The influence of cells on the corrosion behavior biomedical magnesium alloy is an important but less studied topic, which helpful for understanding inconsistent rates between in vitro and vivo experiments. In this work, macrophages were directly cultured Mg-2.1Nd-0.2Zn-0.5Zr (wt %, abbreviated as JDBM) surface 72 or 168 hours. Macrophages retained good viability generation reactive oxygen species (ROS) was greatly promoted alloy. Weight loss, Mg(2+) concentration, cross-section observation...
Bone defects seriously affect patients' quality of life and are difficult to repair, the use biodegradable porous scaffolds for bone defect repair has gradually become a hot spot in field repair. The metal scaffold constructed with Zn covered calcium phosphorus coating is high-quality material. However, rapid cannot be achieved only by trace elements Ca, P, Zn, which beneficial regeneration, so material that promotes regeneration must compounded. Platelet-rich plasma class liquid complexes...
Background: The removal of permanent internal fixation devices by secondary surgery could be avoided if these were made degradable magnesium and alloys. Before such implants can used clinically, however, the biological effect exposure on surrounding bone must evaluated. Previous studies have focused formation; few examined effects quality that affect many biomechanical properties.
In this study, biomimetic porous magnesium alloy scaffolds were prepared to repair femoral bone defects in ovariectomized osteoporotic rats. The purpose of the study was investigate effect on repairing and possible mechanisms. animal model osteoporosis established female SD Three months later, a defect 3 mm diameter depth created lateral condyle right femur. rats then randomly divided into two groups: an experimental group control group. Four weeks after surgery, gross specimens observed...
Yinhua pinggan granule (YHPGKL), a traditional Chinese medical compound, could treat pneumonia. Although previous studies demonstrated the protective and therapeutic effects of YHPGKL on pneumonia, its potential molecular mechanisms effective components are still elusive. Herein, we performed network pharmacology analysis to determine possible signaling pathways involved in YHPGKL. A total 119 257 target proteins were identified, among which 117 interacted with 113 related Then,...
Cartilage defects caused by joint diseases are difficult to treat clinically. Tissue engineering materials provide a new means promote the repair of cartilage defects. The purpose this study is design novel scaffold porous magnesium alloy loaded with icariin and sustained release in order explore effect possible mechanism repairing SD rat knee articular defect. We constructed type icariin/porous scaffold, observed structure electron microscope, detected drug biological safety, established an...
The development of Mg and its alloys as bone screws has garnered significant attention due to their exceptional biocompatibility unique biodegradability. Notably, the controlled release Mg2+ ions during degradation can positively influence fracture healing. advantages raise appeal for application in tissue engineering. However, porous scaffolds, while offering high surface areas, face challenges maintaining slow rates preserving interconnectivity, which are crucial features ingrowth. To...
Understanding the interaction of T-cell receptor (TCR) with major histocompatibility-peptide (MHC-peptide) complex is extremely important in human immunotherapy and vaccine development. However, due to limited available data, performance existing models for predicting receptors complexes still unsatisfactory. Deep learning have been applied prediction tasks various fields achieved better results compared other traditional models. In this study, we leverage gMLP model combined attention...
Degradability of bone tissue engineering scaffold that matching the regeneration rate could allow a complete replacement host tissue. However, porous structure biodegradable Mg scaffolds certainly generated high specific surface area, and three-dimensional interconnected pores provided fast pervasive invasion entrance for corrosive medium, rising concern structural integrity during degradation. To clarify evolution (3D) structure, semi-static immersion tests were carried out to evaluate...