Ayed A. Alshamrani

ORCID: 0000-0003-2384-943X
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About
Contact & Profiles
Research Areas
  • Regulation of Appetite and Obesity
  • Pancreatic function and diabetes
  • Stress Responses and Cortisol
  • Neuroendocrine regulation and behavior
  • Diabetes Management and Research
  • Neuroscience of respiration and sleep
  • Adipose Tissue and Metabolism
  • Hypothalamic control of reproductive hormones
  • Hormonal and reproductive studies
  • Diet and metabolism studies
  • Growth Hormone and Insulin-like Growth Factors
  • Pharmacological Effects and Toxicity Studies
  • Quality and Safety in Healthcare
  • Pesticide Exposure and Toxicity
  • Metabolism and Genetic Disorders
  • Occupational Health and Safety Research
  • Insect Pest Control Strategies
  • Pregnancy and Medication Impact
  • Immune Cell Function and Interaction
  • Curcumin's Biomedical Applications
  • Metabolism, Diabetes, and Cancer
  • Chemotherapy-induced organ toxicity mitigation
  • Neuroscience and Neuropharmacology Research
  • Sleep and Wakefulness Research

Jazan University
2023-2025

University of Louisiana at Monroe
2017-2023

Cisplatin (CP) is a platinum compound of the alkylating agent class that used for treatment various types cancer. However, CP treatments in cancer patients are accountable nephrotoxicity, as it major adverse effect. Hence, this research study was proposed to investigate nephroprotective effect diosmin, flavonoid glycoside hesperidin derivatives against cisplatin-induced kidney damage. Wistar rats received single intraperitoneal (i.p) injection (7.5 mg/kg, i.p) induce nephrotoxicity. The...

10.3390/molecules28031302 article EN cc-by Molecules 2023-01-30

Astrocyte glycogen is dynamically remodeled during metabolic stability and provides oxidizable l-lactate equivalents neuroglucopenia. Current research investigated the hypothesis that ventromedial hypothalamic nucleus (VMN) metabolism controls glucostimulatory nitric oxide (NO) and/or glucoinhibitory gamma-aminobutyric acid (GABA) neuron 5’-AMP-activated protein kinase (AMPK) transmitter marker, e.g., neuronal synthase (nNOS), glutamate decarboxylase 65/67 (GAD) expression. Adult...

10.1152/ajpregu.00292.2020 article EN AJP Regulatory Integrative and Comparative Physiology 2021-04-07

This review delves into personal protective equipment (PPE) usage and adherence among healthcare professionals. The research highlights the role of knowledge awareness in shaping compliance behaviors, stressing importance education training initiatives. Factors like discomfort, perceived risk, cognitive beliefs at a level with organizational culture, leadership, positive safety environment impact result. benefits using PPE range from preventing healthcare-associated infections to promoting...

10.18203/2394-6040.ijcmph20250043 article EN International Journal of Community Medicine and Public Health 2025-01-22

The glucose polymer glycogen is a vital fuel reserve in the brain. mediobasal hypothalamic energy sensor AMP-activated protein kinase (AMPK) maintains glucostasis via neurotransmitter mechanisms that suppress [γ-aminobutyric acid; GABA] or stimulate [nitric oxide; steroidogenic factor-1 (SF1)] counter-regulatory outflow. This study investigated whether glycogen-derived supply critical screened variable ventromedial nucleus (VMN) monitoring of neuro-metabolic stability during and/or insulin...

10.14814/phy2.13484 article EN cc-by Physiological Reports 2017-12-01

Glycogen metabolism shapes ventromedial hypothalamic nucleus (VMN) control of glucose homeostasis. Brain glycogen mass undergoes compensatory expansion post-recovery from insulin-induced hypoglycemia (IIH). Current research utilized combinatory high-resolution microdissection/high-sensitivity Western blotting to investigate whether IIH causes residual adjustments in within the metabolic-sensory ventrolateral VMN (VMNvl). Micropunch-dissected tissue was collected rostral, middle, and caudal...

10.21307/ane-2021-019 article EN Acta Neurobiologiae Experimentalis 2021-01-01

The ventromedial hypothalamic nucleus (VMN) glucoregulatory neurotransmitters γ-aminobutyric acid (GABA) and nitric oxide (NO) signal adjustments in glycogen mobilization. Glucocorticoids control astrocyte metabolism vitro. classical (type II) glucocorticoid receptor (GR) is expressed key brain structures that govern glucostasis, including the VMN. Current research addressed hypothesis forebrain GR regulation of VMN synthase (GS) phosphorylase (GP) protein expression correlates with...

10.15226/2374-6890/8/1/001148 article EN Journal of Endocrinology and Diabetes 2021-01-13

Ventromedial hypothalamic nucleus (VMN) glycogen metabolism affects local glucoregulatory signaling. The hindbrain metabolic-sensitive catecholamine (CA) neurotransmitter norepinephrine controls VMN phosphorylase (GP)-muscle (GPmm) and -brain (GPbb) type expression in male rats. Present studies addressed the premise that CA regulation of hypoglycemic patterns metabolic enzyme protein is sex-dimorphic, this signal responsible for sex differences acclimation these profiles to recurrent...

10.1016/j.endmts.2021.100087 article EN cc-by-nc-nd Endocrine and Metabolic Science 2021-02-16
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