A5051224941- Chemotherapy-induced organ toxicity mitigation
- Nigella sativa pharmacological applications
- Essential Oils and Antimicrobial Activity
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic function and diabetes
- Ion Transport and Channel Regulation
- Renal function and acid-base balance
- Neuroinflammation and Neurodegeneration Mechanisms
- Forensic Toxicology and Drug Analysis
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Curcumin's Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Biological Activities
- Renin-Angiotensin System Studies
- Pesticide Exposure and Toxicity
- Natural Antidiabetic Agents Studies
- Effects and risks of endocrine disrupting chemicals
- Biochemical effects in animals
- Pain Mechanisms and Treatments
- Selenium in Biological Systems
- Advanced Drug Delivery Systems
- Sesame and Sesamin Research
- Carcinogens and Genotoxicity Assessment
- Stress Responses and Cortisol
Jazan University
2018-2025
Maternity and Children's Hospital
2022-2025
Princess Nourah bint Abdulrahman University
2024
McGill University
2023
King Khalid University
2023
Institute of Pharmacology
2021
King Saud bin Abdulaziz University for Health Sciences
2021
King Abdullah International Medical Research Center
2021
National University of Malaysia
2020
University of Cincinnati
2015-2018
Abstract The present study was carried out to develop cisplatin-loaded chitosan nanoparticles (CCNP) and nanoparticle surface linked rituximab (mAbCCNP) as targeted delivery formulations. two formulations (CCNP mAbCCNP) exhibited significant physicochemical properties. zetapotential (ZP) values of CCNP mAbCCNP were 30.50 ± 5.64 26.90 9.09 mV, respectively; while their particle sizes 308.10 1.10 349.40 3.20 z.d.nm, respectively. poly dispersity index (PDI) 0.257 0.030 (66.6% PDI), that 0.444...
<bold>Background:</bold> Coronavirus disease-2019 (COVID-19) was declared a "pandemic" by the World Health Organization (WHO) in early March 2020. Globally, extraordinary measures are being adopted to combat formidable spread of ongoing outbreak. Under such conditions, people's adherence preventive is greatly affected their awareness disease. <bold>Aim:</bold> This study aimed assess level and preparedness fight against COVID-19 among healthcare workers (HCWs) other residents South-West...
Thymoquinone is the active constituent of Nigella sativa , having antioxidant and anti-inflammatory actions. In present study, we have analyzed effects thymoquinone on doxorubicin (DOX) induced cardiotoxicity in mice. this experiment, thirty mice (25–35 gm) were divided into five groups (Groups A, B, C, D, E) each containing six animals. Normal saline was given to a control group (Group A) for 14 days. Cardiotoxicity by DOX (15 mg/kg, i.p.) Group once 13th day Groups C D also received then...
The present study was designed to discover novel secondary antibiotic metabolites from Actinomycetes species the soil of Rijal Almaa, Saudi Arabia. A laboratory-scale benchtop fermentation utilized for demonstration antibiotics actinomycetes. Fourier transform-infrared spectroscopy (FT-IR) analysis fermented product (FP) carried out, which showed unique fingerprint regions indicating presence phenolic hydroxyl groups, aliphatic compounds, carboxylic esters, isothiocyanate, etc. GC-MS FP...
Chitosan is a biocompatible polysaccharide that has been widely exploited in biomedical and drug delivery applications.This study explores the renoprotective effect of chitosan nanoparticles vivo rats.Chitosan were prepared via ionotropic gelation method, several vitro characterizations performed, including measurements particle size, zeta potential, polydispersity index, Fourier transform-infrared spectroscopy, differential scanning calorimetry, transmission electron microscopy (TEM)...
This study investigated the potential hepatoprotective activity of curcumin-incorporated nano-lipid carrier (Cur-NLC) against cypermethrin (Cyp) toxicity in adult Wistar male rats. All animals groups III, IV, V, and VI were subjected to Cyp (50 mg/kg) for 15 days. Three different doses Cur-NLC (1, 2.5, 5 mg/kg/day) administered orally 10 The toxic effects evaluated considering increases serum hepatic biomarkers alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP),...
Cyclophosphamide (CPM) is a classical alkylating agent used in different cancer chemotherapy regimens and restricted due to severe adverse effects, including hepatotoxicity. Natural or plant-derived antioxidants such as capsaicin were utilized this study examine the hepatoprotective benefits against cyclophosphamide-induced The rats divided into five groups: normal control group, toxic group (CPM), an intraperitoneal injection of single dose 200 mg/kg b.w. on fourth day, pretreated with two...
MicroRNAs (miRNAs) have been extensively examined in pathological cardiac hypertrophy. However, few studies focused on profiling the miRNA alterations physiological hypertrophic hearts. In this study we generated a transgenic mouse model with cardiac-specific overexpression of miR-223. Our results showed that elevation miR-223 caused hypertrophy enhanced function but no fibrosis. Using next generation RNA sequencing, observed most dys-regulated genes (e.g. Atf3/5, Egr1/3, Sfrp2, Itgb1,...
Abstract The purpose of this study was to develop a novel nano antibacterial formulation dextran sulfate sodium polymer. (DSS) nanoparticles were formulated with gelation technique. exhibited significant physicochemical and effective properties, zeta potential − 35.2 mV, particle size 69.3 z d nm, polydispersity index 0.6, percentage 77.8. DSS stable up 102 °C. Differential scanning calorimetry revealed an endothermic peak at 165.77 °C in 12.46 min, while XRD analysis 2 θ depicted various...
Acetaminophen (APAP) is used as a primary drug due to its antipyretic and analgesic activity. The mechanism of action APAP toxicity in the liver depletion glutathione which elicited free radicals generation. Therefore, objective our work investigate induced damage repair by radical scavenging activity cinnamon oil (CO) male Wistar rats. To effects CO at different doses (50, 100 200 mg/kg b.w.), animals were given single oral dose per day for 14 days between 12:00−1:00 PM. biochemical...
Background: Artemisia absinthium L is an ornamental plant widespread in Saudi Arabia. Traditionally, the has been used Arabic medicine. But scientific evidence of bioactive compounds and their medicinal value was not yet explored widely. Objective: The study designed to analyse principles properties L, a traditional herb grown southern part Methods: present Hot Methanolic Extract Leaves (HMEL) L. by GC-MS analysis. cytotoxicity effect HMEL determined against MCF-7 breast cancer cells ATCC...
Cyclophosphamide is an anticancer drug with a wide spectrum of clinical uses, but its typical side effects are multiple complications, including nephron toxicity. The possible molecular mechanism the nephroprotective action sesamin (SM) against cyclophosphamide (CP) induced renal toxicity was investigated in rats by understanding oxidative stress and inflammatory cytokines. In this study, were arbitrarily grouped into following four groups: normal control group (CNT); CP-induced group;...
Cisplatin (CP) is a platinum compound of the alkylating agent class that used for treatment various types cancer. However, CP treatments in cancer patients are accountable nephrotoxicity, as it major adverse effect. Hence, this research study was proposed to investigate nephroprotective effect diosmin, flavonoid glycoside hesperidin derivatives against cisplatin-induced kidney damage. Wistar rats received single intraperitoneal (i.p) injection (7.5 mg/kg, i.p) induce nephrotoxicity. The...
The study aimed to develop cisplatin-loaded PEGylated chitosan nanoparticles. optimal batch of nanoparticles had a + 49.9 mV zeta potential, PDI 0.347, and % 58.9. Nanoparticle size was 741.4 z. d.nm, the in diameter 866.7 ± 470.5 nm, nanoparticle conductivity colloidal solution 0.739 mS/cm. Differential scanning calorimetry (DSC) revealed that sharp endothermic peaks at temperatures 168.6 °C. thermogravimetric analysis (TGA) showed weight loss nanoparticles, which observed as 95% 262.76 XRD...
Cypermethrin (CPM) is the most toxic synthetic pyrethroid that has established neurotoxicity through oxidative stress and neurochemical agitation in experimental rats. The effects are supposed to be mediated by modifying sodium channels, reducing Na-K ATPase, acetylcholine esterase (AchE), monoamine oxidase (MAO). use of curcumin nanoparticles (NC) have potent antioxidant, anti-inflammatory antiapoptotic properties with improved bioavailability attenuates rat brains. To test this hypothesis,...
Cyclophosphamide is an antineoplastic agent that has a broad range of therapeutic applications; however, it numerous side effects, including cardiotoxicity. Furthermore, chili peppers contain substance called capsaicin, having antioxidant and anti-inflammatory effects. Thus, this research paper focuses on the potential mechanism capsaicin's cardioprotective activity against cyclophosphamide-induced cardiotoxicity by measuring expression oxidative inflammatory marker such as interleukins...