A5047069276- Retinal Development and Disorders
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Adipose Tissue and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- CRISPR and Genetic Engineering
- Corneal Surgery and Treatments
- Photochromic and Fluorescence Chemistry
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Graphene and Nanomaterials Applications
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Tissue Engineering and Regenerative Medicine
- Peroxisome Proliferator-Activated Receptors
- Retinal and Macular Surgery
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Retinal Diseases and Treatments
Royan Institute
2014-2025
Academic Center for Education, Culture and Research
2013-2025
University of Isfahan
2021
University of Science and Culture
2018
The mammalian retina contains multiple cellular layers, each carrying out a specific task. Such controlled organization should be considered as crucial factor for designing retinal therapies. maintenance of layered complexity through the use scaffold-free techniques has recently emerged promising approach clinical ocular tissue engineering. In an attempt to fabricate such model, we are proposing herein unique inkjet bioprinting system applied deposition photoreceptor cells (PRs) layer on top...
Biological and biomimetic decellularized scaffolds can mimic a natural tissue environment to derive cell proliferation differentiation without eliciting adverse immune responses during regeneration. Polymeric nanofibrous membranes also served as appropriate matrices for cellular behavior because of their resemblance physical dimensions extracellular matrix (ECM), while they often have insufficient biological cues address the phenotype. In this study, we designed bio-engineered through...
Cotransplantation of neural progenitors (NPs) with Schwann cells (SCs) might be a way to overcome low rate neuronal differentiation NPs following transplantation in spinal cord injury (SCI) and the improvement locomotor recovery. In this study, we initially generated from human embryonic stem (hESCs) investigated their potential for functional recovery when cocultured SCs vitro cotransplanted rat acute model contused SCI. Cocultivation results revealed that presence provided consistent...
Transplantation of retinal cells has recently provided a promising therapeutic approach for degeneration. Here, we differentiated initially progenitors (RPs) from adherent feeder-free human embryonic stem (hESCs) with the use defined media supplemented specific combination growth factors. The RPs highly (>80%) expressed related molecular features that included Six3 at an early stage in addition to Crx, Rx, Pax6, Otx2, and Chx10 later stage. Next, examined induction photoreceptors by Shh...
Abstract A critical element in tissue engineering involves the fabrication of a three‐dimensional scaffold. The scaffold provides space for new formation, supports cellular ingrowth, and proliferation mimics many roles extracellular matrix. Poly(3‐hydroxybutyrate) (PHB) is most thoroughly investigated member polyhydroxyalkanoates (PHAs) family that has various degrees biocompatibility biodegradability applications. In this study, we fabricated PHB scaffolds by utilizing electrospinning...
Purpose: Despite the significant advances in modeling of biomechanical aspects cell microenvironment, it remains a major challenge to precisely mimic physiological condition particular niche. Here, metal–organic frameworks (MOFs) have been introduced as feasible platform for multifactorial control cell-substrate interaction, given wide range physical and mechanical properties MOF materials their structural flexibility. Results: In situ crystallization zeolitic imidazolate framework-8 (ZIF-8)...
Abstract Ciliary neurotrophic factor (CNTF) promotes survival and/or differentiation of a variety neuronal cells including retinal ganglion (RGCs). Delivery CNTF requires suitable medium capable mediating diffusion and premature release within the target tissue. Polymeric tissue-engineered scaffolds have been readily used as substrates for cell transplantation, expansion, and, carriers growth factors. Their functions to RGC proliferation remained so far unexplored, especially affinity...
Increased possibility of universality ooplasmic reprogramming factors resulted in a parallel increased interest to use interspecies somatic cell nuclear transfer (iSCNT) address basic questions developmental biology and improve the feasibility therapy. In this study, interactions between human cells ovine oocytes were investigated. Nuclear remodeling events first observed 3 h post-iSCNT as swelling, chromosome condensation, spindle formation. A time-dependent decrease maturation promoting...
ABSTRACT Recently, there are significant interests in the development of biomaterials with nonlinear response to an external stimulus. Thermoresponsive polymers as a well‐known class stimuli‐responsive materials represent reversible hydrophilicity/hydrophobicity characteristics around critical temperature. This switchable behavior applies for nondestructive cellular detachment from cultivation substrates. In this study, poly (N‐isopropylacrylamide) (PNIPAAm)‐grafted dishes were made up...
Human embryonic stem cells (hESCs) are vulnerable to cell death upon dissociation. Thus, dissociation is an obstacle in culturing, maintaining, and differentiating of hESCs. To date, apoptosis has become the focus research into nature triggered by cellular detachment; it remains baffling whether another form can occur Here, we demonstrate that iron accumulation subsequently lipid peroxidation responsible for dissociation-mediated hESC death. Moreover, found a decrease glutathione peroxidase...