A5041933394- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Immune Cell Function and Interaction
- Growth Hormone and Insulin-like Growth Factors
- Testicular diseases and treatments
- Radiomics and Machine Learning in Medical Imaging
- Reproductive System and Pregnancy
- HER2/EGFR in Cancer Research
- Child Nutrition and Water Access
- Immune cells in cancer
- AI in cancer detection
- Obesity, Physical Activity, Diet
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Breast Cancer Treatment Studies
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Ovarian function and disorders
- Breast Lesions and Carcinomas
- Trauma and Emergency Care Studies
- GDF15 and Related Biomarkers
- Body Composition Measurement Techniques
- Osteoarthritis Treatment and Mechanisms
- Ubiquitin and proteasome pathways
St Göran's Children's Hospital
2023-2025
Karolinska Institutet
2010-2025
Saint Göran Hospital
2020-2024
University of Wisconsin–Madison
2024
Universidad Mariano Galvez
2019
Stockholm South General Hospital
2014-2017
Karolinska University Hospital
2014-2016
Health and Human Development (2HD) Research Network
2010-2013
New York University
2013
Boston Children's Hospital
2004-2006
BackgroundArtificial intelligence (AI) as an independent reader of screening mammograms has shown promise, but there are few prospective studies. Our aim was to conduct a clinical trial examine how AI affects cancer detection and false positive findings in real-world setting.MethodsScreenTrustCAD prospective, population-based, paired-reader, non-inferiority study done at the Capio Sankt Göran Hospital Stockholm, Sweden. Consecutive women without breast implants aged 40–74 years participating...
Adoptive natural killer (NK) cell transfer is being increasingly used as cancer treatment. However, clinical responses have so far been limited to patients with hematological malignancies. A potential limiting factor in solid tumors defective homing of the infused NK cells tumor site. Chemokines regulate migration leukocytes expressing corresponding chemokine receptors. Various tumors, including renal carcinoma (RCC), readily secrete ligands for receptor CXCR2. We hypothesize that infusion...
PURPOSE The proven efficacy of human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate therapy for treating HER2-low breast cancers necessitates more accurate and reproducible HER2 immunohistochemistry (IHC) scoring. We aimed to validate performance utility a fully automated artificial intelligence (AI) solution interpreting IHC in carcinoma. MATERIALS AND METHODS A two-arm multireader study 120 whole-slide images from four sites assessed scoring by surgical pathologists...
The present investigation examines the influence of IGF-I and role receptor (IGF-IR) in apoptosis/survival Leydig cells. Immunohistochemical analysis rat testis at different ages revealed that level phosphorylated IGF-IR increases from birth to d 20 postnatal life, remaining high adult testis. Western blotting this is higher cells isolated 40-d-old than 10- or 60-d-old rats. Application terminal deoxyribonucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling assay...
Renal cell carcinoma (RCC) is recognized as an immunogenic tumor, yet tumor-infiltrating lymphocytes often exhibit diminished effector function. However, the mechanisms underlying reduced T and NK activity in RCC remain unclear. Here, we examined immune contexture patients undergoing nephrectomy to identify immune-related biomarkers associated with disease progression. Immune phenotypes secretion profiles were assessed using flow cytometry Luminex multiplex analysis. Supervised multivariate...
Abstract Humanin (HN) is a 24 amino acids peptide with potent neuro‐survival properties that protects against damage associated Alzheimer's disease. In the present report, we have demonstrated by immunohistochemical analysis and Western blotting pattern of expression rat humanin (HNr) in testis 10‐ to 60‐day‐old rats. The Leydig cells 40‐ day‐old rats expressed this at high levels; HNr expanded include Leydig, endothelial, peritubular germ cells. As monitored blotting, was released into...
Published Growth studies from Latin America are limited to growth references Argentina and Venezuela. The aim of this study was construct reference curves for height, weight, body mass index (BMI) head circumference Colombian children in a format that is useful following the individual child as tool public health.Prospective measurements 27 209 middle upper socio-economic level families were processed using generalised additive models location, scale shape (GAMLSS).Descriptive statistics...
The cytokine IL-1α is produced constitutively by the intact testis, but its function in this organ remains largely unknown. In study we examined cooperation between and GH IGFs with regard to stimulation of steroidogenesis Leydig cells from 40-d-old rats vitro. alone stimulated testosterone (T) dihydrotestosterone (DHT) production. GH, IGF-I, or IGF-II was without effect on T production, they were found elevate DHT release, albeit an obvious dose-response effect. Costimulation IGF-I elevated...
The origin of pelvic serous carcinoma continues to be controversial. Recent studies patients undergoing primary surgery for ovarian, peritoneal, and uterine carcinomas have indicated the value complete fimbrial sampling detecting occult tubal intraepithelial (STIC). Evidence suggests that a significant proportion may arise from in situ lesions on distal fallopian tube. In this study, 14 consecutive cases interval debulking after neoadjuvant chemotherapy were reviewed, using both hematoxylin...
The secretory insulin-like growth factor-binding protein-3 (IGFBP-3) induces apoptosis via both factor-I (IGF-I)-dependent and -independent mechanisms.Here, we have examined the effects of IGFBP-3 on Leydig cell apoptosis, proliferation steroidogenesis.Immunohistochemical analysis testes rats at different ages revealed that is expressed first after 20 days postnatal life present a high level in adult testis.In addition, Western blotting showed expression cells isolated from 60-day-old higher...
El crecimiento infantil está condicionado por factores genéticos, ambientales, sociales y económicos, lo que es útil elaborar gráficas de locales. La Fundación Cardio-Infantil, Instituto Cardiología, la Asociación Colombiana Endocrinología Pediátrica, con el apoyo del Karolinska Institutet en Suecia Colciencias están desarrollando los estándares normativos para evaluar expresión potencial biológico niños Colombia. Establecer datos antropométricos/auxológicos referencia adolescentes...
Viruses are key drivers of microbial diversity, nutrient cycling, and co-evolution in ecosystems, yet their study is hindered due to challenges culturing. Traditional gene-centric methods, which focus on a few hallmark genes like for capsids, miss much the viral genome, leaving proteins functions undiscovered. Here, we introduce two powerful annotation-free metrics, V-score VL-score, designed quantify virus-likeness protein families genomes create an open-access searchable database,...
It is uncommon for extramammary tumors to metastasize the breast, and very few cases describing metastasis of primary uterine leiomyosarcoma breast have been reported. We present case a 51-year-old woman diagnosed with 10 years ago after hysterectomy. Ultrasonography, mammography, cytology were used establish preliminary diagnosis that was confirmed upon examination excised tumor show rare soft tissue composed atypical spindle cells increased proliferation rate. discuss importance...