A5003684140- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Proteoglycans and glycosaminoglycans research
- Botulinum Toxin and Related Neurological Disorders
- Inflammatory mediators and NSAID effects
- Neurological disorders and treatments
- Orthopaedic implants and arthroplasty
- Musculoskeletal synovial abnormalities and treatments
- Rheumatoid Arthritis Research and Therapies
- Hereditary Neurological Disorders
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Estrogen and related hormone effects
- Orthopedic Infections and Treatments
- Effects and risks of endocrine disrupting chemicals
- Hip and Femur Fractures
- Tendon Structure and Treatment
- Medicinal plant effects and applications
- Orthopedic Surgery and Rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biomedical Ethics and Regulation
- Pancreatic function and diabetes
- Polysaccharides Composition and Applications
- Dyeing and Modifying Textile Fibers
Curtin University
2022
New York University
2011-2021
CytoDel (United States)
2016-2021
New York University Langone Orthopedic Hospital
2010-2021
NYU Langone Health
2015-2018
Brigham and Women's Hospital
2016
Harvard University
2016
Weatherford College
2013
Hospital for Special Surgery
2011
Columbia University Irving Medical Center
1981-2011
Objective. This randomized controlled study addressed whether sonographic needle guidance affected clinical outcomes of intraarticular (IA) joint injections. Methods. In total, 148 painful joints were to IA triamcinolone acetonide injection by conventional palpation-guided anatomic or image-guided enhanced with a one-handed control syringe (the reciprocating device). A one-needle, 2-syringe technique was used, where the first used introduce needle, aspirate any effusion, and anesthetize...
Background: Preoperative risk stratification and optimization of preoperative care may be helpful in reducing readmission rates after primary total joint arthroplasty. Assessment the predictive value individual modifiable factors without a tool to assess cumulative not provide proper patients with regard potential readmissions. As part Perioperative Orthopaedic Surgical Home model, we developed scoring system, Readmission Risk Tool (RRAT), which allows for undergoing elective arthroplasty at...
We studied whether sonographic needle guidance affected the outcomes of intraarticular (IA) injection for inflammatory arthritis.Joints with arthritis (n = 244; 76% rheumatoid arthritis, 3% small joints, 51% intermediate, and 46% large) were randomized to by conventional palpation-guided anatomic (120 joints) or image-guided enhanced a 1-handed reciprocating procedure device mechanical syringe (124 joints). A 1-needle, 2-syringe technique was used. After IA placement synovial space dilation...
The present randomized controlled study investigated whether sonographic needle guidance affected the outcomes of intra-articular injection for osteoarthritis knee.Ninety-four noneffusive knees with were to by conventional palpation-guided anatomic landmark or image-guided enhanced a 1-handed mechanical (the reciprocating procedure device) syringe. After placement and synovial space dilation confirmed sonography, syringe exchange was performed, 80 mg triamcinolone acetonide injected second...
Intraneuronal delivery of a therapeutic, single-domain antibody reverses botulism symptoms and increases survival mice, guinea pigs, monkeys.
Background Greater levels of self-reported pain, pain catastrophizing, and depression have been shown to be associated with persistent functional limitation after surgeries such as TKA. It would useful for clinicians able measure these factors efficiently. Questions/purposes We asked: (1) What is the association whole-body osteoarthritis (OA)-related knee function, mental health? (2) sensitivity specificity different cutoffs body diagram region categories in relation catastrophizing? Methods...
The cytosol fraction of rat pancreas [100,000 X g (for 1 h) supernatant] demonstrated specific but nonsaturable binding [3H]estradiol in the concentration range 2-50 10(-9) M. Scatchard analysis specifically bound [3H]estradiol, determined by isotope dilution technique (competition with excess unlabeled estradiol), indicated a single class sites (approximately 4.4 pmol/mg protein) an apparent Kd 5 10(-8) Such fractions, prepared from homogenates that contained protease inhibitors, when...
Abstract Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has potential eliminate toxicity without disrupting neuron-specific targeting, thereby creating a molecular vehicle capable delivering therapeutic cargo neuronal cytosol. Building upon previous work, we have developed an toxic d erivative ( ad ) BoNT/C1 through rationally designed amino acid...
Abstract Background The extended knee lateral midpatellar portal for intraarticular injection of the is accurate but not practical all patients. We hypothesized that a modified anteriolateral where synovial membrane medial femoral condyle target would be highly and effective knee. Methods 83 subjects with non-effusive osteoarthritis were randomized to using bent versus standard portal. After hydrodissection lidocaine mechanical syringe (reciprocating procedure device), 80 mg triamcinolone...
Supernatant fractions from rat pancreas bind approximately 300 fmol of [3H]estradiol per mg protein when incubated with 5 nM for 1 hr at room temperature. Passage through gel filtration columns reduces binding in the eluate to 1% its initial activity. Extracts supernatant contain a factor that reactivates filtrates. Addition accessory fractional eluates gives one sharp peak Since cannot be reactivated as much or more can reactivated, it is concluded interaction and [3H]estradiol-binding...
We have previously described genetic constructs and expression systems that enable facile production of recombinant derivatives botulinum neurotoxins (BoNTs) retain the structural trafficking properties wt BoNTs. In this report we describe one such derivative, BoNT/A ad, which was rendered atoxic by introducing two amino acid mutations to light chain (LC) BoNT/A, is being developed as a molecular vehicle for delivering drugs neuronal cytoplasm. The binding, internalization, intracellular ad...
Inter-α-inhibitor, TSG-6, and hyaluronan have important functions in fertility inflammation. Two subunits of inter-α-inhibitor, the heavy chains, form covalent bonds with TSG-6 or vitro. TSG-6-heavy chain complexes serve as intermediates transfer chains from inter-α-inhibitor to hyaluronan. In vivo, addition these complexes, stable ternary both been demonstrated ovulatory cumulus oophorus. our ongoing efforts characterize multiple interactions between hyaluronan, we recently characterized...