Abstract Background Differentiated thyroid carcinoma (DTC) generally has a favourable prognosis with standard treatments; however, the risks of local recurrence and distant metastases remain concern, affecting substantial proportion patients. Radioactive iodine (RAI) refractoriness further complicates DTC management, leading to substantially reduced survival rates. In this study, we aimed identify anexelekto (AXL) expression TERT promoter mutation as potential predictors RAI-refractory DTC....

Luka akan menimbulkan masalah jika penanganannya kurang baik sehingga menyebabkan luka kronik. Mengkudu ( Morinda citrifolia L .) merupakan tanaman khas daerah tropis termasuk Indonesia, yang buah, daun, dan akarnya sering digunakan dalam pengobatan tradisional, di antaranya untuk menyembuhkan luka. Penelitian dengan rancangan eksperimental sederhana ini bertujuan mengetahui efek penggunaan ekstrak etanol daun mengkudu terhadap penyembuhan pada pemberian topikal, melihat gambaran...

Background . The diagnosis of Osteosarcoma (OSA) is not always straightforward. OSA may resemble Other Primary Bone Tumours (OPBT). osteosarcoma sometimes difficult especially in a very small specimen. Immunohistochemistry one ancillary testing types that can help the many tumours. aim this study was to evaluate validity Osteocalcin (OCN) and Alkaline Phosphatase (ALP) immunohistochemistry discriminating from OPBT. Method This included 50 selected human primary bone tumours, 25 cases...

Aim: To obtain clinicopathological characteristics of colorectal cancer among young native Indonesians and to assess MLH1, MSH2, SMAD4 protein expressions, comparing them with a matched population patients aged 60 years old older.Methods: Medical records 40 or younger older from several hospitals in three Indonesian cities – Jakarta, Makassar, Bandung - were reviewed. The "native" ethnic groups selected those originating Java, Makassar (South Celebes), Minangkabau (West Sumatra). Ethnicity...

Cancer stem cells are involved in radioresistant cancers. Transcription factors Sry-related HMG box (SOX2) and octamer binding transcription factor 4 (OCT4) can confer pluripotent cell characteristics self-renewal ability carcinogenesis, metastasis, tumor recurrence, resistance to therapy. Apoptosis, DNA repair, telomerase also contribute radioresistance. We sought identify the role of SOX2 OCT4 as cancer markers their effects on apoptosis (via caspase 3), repair (Chk1) (hTERT) conferring...

Background: As in other developing countries, cervical cancer is the most frequent gynecologic malignancy Indonesia. Persistent high risk genotypes of human papillomavirus (HPV) that infect tissue have been established as etiology cancer. This study aimed to explore profile patients and infected HPV at Dr. Hasan Sadikin General Hospital-Bandung. Materials Methods: During year 2010, 554 were registered. In a subset during July - November 40 randomized fresh biopsies tested for genotype after...

Endometriosis is a gynecological disease characterized by the presence of endometrial-like tissue outside uterine cavity. Remodeling extracellular matrix (ECM) prerequisite for implantation. The metalloproteinase (MMP) and its inhibitor, inhibitor metalloproteinase-1 (TIMP-1), in shed endometrium cells has significant role ECM degradation. A case-control study was performed to find other diagnostic markers using menstrual blood. We examined sample 68 women who visited gynecology clinic Dr...

Testicular epidermoid cysts (TECs) are rare benign testicular neoplasms. Recently, listed as teratoma of prepubertal type, however it is still difficult to differentiate the cyst from malign tumor. Therefore, we would like report at our institution. A 67-year-old man Indonesia, presented with chronical painless mass testis since one year ago. On physical examination obtained normal penile structure descended testicles, palpable intrascrotal size 10 × 7 5 cm, firm consistency, immobile,...

Bladder leiomyoma is a rare, benign tumor of the bladder. We present first large endovesical case report in Indonesia and largest bladder without any post-operation symptoms. A 42-year-old female came with painless hematuria irritative symptoms past year. Cystoscopy open excision showed well-encapsulated papillary solid mass at trigone (7 x 6.5 × 4 cm weight 800 g). Postoperative histopathology confirmed diagnosis urinary Open had good outcomes on patients.

Background: Tumour-infiltrating lymphocytes CD8+ (TILs CD8+) as an anticancer immune response and Programmed Death-Ligand 1 (PD-L1) checkpoint molecule expression are important in colorectal cancer (CRC) their correlates with the status progression of cancer. The primary objective this study is to examine relationship between TILs PD-L1 levels CRC metastasis provide insights into microenvironment’s role metastasis, potentially improving patient outcomes treatment response. Methods: This was...

BACKGROUND: Colorectal Adenocarcinoma (ADCCR) is the third most cancer not only in world but also Indonesia. There were 623 cases of ADCCR at Dr Hasan Sadikin hospital within 2015-2017. Both KRAS and TP53 mutation are known as genes which involve carcinogenesis through same pathway, namely chromosomal instability pathway. In West Java, researches focusing on p53 a correlation between both biomarkers among patients still limited. AIM: Therefore, this research aimed to perceive gene expression...

Medulloblastoma is a highly malignant embryonal tumor which commonly arises in the cerebellum. It relatively rare and accounts for less than 2% of all primary brain tumors. The primarily occurs childhood; however, rarely, it may be found adult population. In addition, medulloblastoma population shows features are quite distinct from pediatric group.We report case 33-year-old man who presented to our institution with history blurred vision both eyes 5 months preceded by intermittent headache...

Pemberian Air Susu Ibu (ASI) yang dilakukan sejak usia dini dan dilanjutkan dengan ASI eksklusif selama 6 bulan dapat menurunkan angka kesakitan kematian bayi, serta meningkatkan tumbuh kembang bayi secara optimal. Namun, global masih sedikit di bawah enam diberikan eksklusif, yaitu sebesar 40%. Beberapa studi telah tentang pentingnya ASI, tetapi pemberian belum memuaskan. Salah satu penyebab rendahnya karena ketidaktahuan ibu proses laktasi menyebabkan kurangnya keyakinan untuk menyusui...

<ns4:p>Background: Using immunohistochemical stains to target specific breast cancer markers has become indispensable for evaluation of small diagnostic tissue specimens, and therefore novel marker cocktails cancers are required. This study was conducted assess the immunoexpression P63 SOX2 in triple negative (TNBC), evaluate predictive value these types TNBC.</ns4:p><ns4:p>Methods: Histological slides paraffin blocks TNBC cases were collected from Dr. Hasan Sadikin Hospital, Bandung,...

BACKGROUND Persistent infection of high risk genotypes human papilloma virus (hrHPV) has been established as the etiological cause for cervical cancer, and most prevalent that infect tissue are HPV-16 HPV-18. However, HPV genotype profile shown to differ according geographical distribution across globe. The present study aimed determine in cancer patients from Bandung, Indonesia. METHODS During period July – November 2010 viral DNA was extracted randomly chosen biopsies subjected...

<ns4:p>Endocrine therapy resistance in Luminal Breast Cancer is a significant issue to be tackled, but currently no specific biomarker could used anticipate this event. p53 mutation widely known as one of Cancer’s most prominent genetic alterations. Its generate various effects Estrogen Receptor and Progesteron molecular works, tangled events leading the aggravation endocrine resistance. Hence possibility utilization an predictive plausible. The purpose review explore latest knowledge role...

<ns4:p><ns4:bold>Background</ns4:bold>: Using immunohistochemical stains to target specific breast cancer markers has become indispensable for evaluation of small diagnostic tissue specimens, and therefore novel marker cocktails cancers are required. This study was conducted assess the immunoexpression P63 SOX2 in triple negative (TNBC), evaluate predictive value these types TNBC.</ns4:p><ns4:p><ns4:bold>Methods</ns4:bold>: Histological slides paraffin blocks TNBC cases were collected from...

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is an uncommon tumor of the stomach that only comprises around 1–6% all tumors stomach. Non-Hodgkin more commonly affects lymph nodes and may spread to spleen bone marrow, whereas extranodal non-Hodgkin less common. Primary gastric further divided based on histologic features; one types MALT lymphoma, which strongly associated with &lt;i&gt;Helicobacter pylori&lt;/i&gt; infection. The first sign disease usually mimicking gastritis....

Purpose: Enhanced recovery after surgery (ERAS) protocol has proven to lower both length of stay and time, while being cost-effective at the same time. There are three ERAS protocols implemented for radical cystectomy (RC). All those were published by different institutions, such as European Association Urology, Société Internationale d'Urologie, American Urological Association. We modified proposed components from preoperative care until postoperative evaluate implementation RC. Standard is...

Terapi target (targeted therapy) pada karsinoma kolorektal merupakan terapi alternatif yang diharapkan memberikan hasil lebih baik diantaranya dengan pemberian metabolit aktif vitamin D, yaitu calcitriol dan inhibitor Phosphatidyl Inositol 3 Kinase (PI3K). Penelitian ini bertujuan untuk mengetahui korelasi imunoekspresi VDR PI3K terhadap derajat diferensiasi adenokarsinoma kolorektal. menggunakan desain potong lintang analisis kategorik dari 30 blok parafin (kelompok low grade high...

<ns4:p>Endocrine therapy resistance in Luminal Breast Cancer is a significant issue to be tackled, but currently, no specific biomarker could used anticipate this event. p53 mutation widely known as one of Cancer’s most prominent genetic alterations. Its generate various effects Estrogen Receptor and Progesterone molecular works, tangled events leading the aggravation endocrine resistance. Hence possibility utilization an predictive plausible. The purpose review explore latest knowledge role...