A5044589939- Global Cancer Incidence and Screening
- Head and Neck Cancer Studies
- Public Health and Nutrition
- Radiation Therapy and Dosimetry
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Tannin, Tannase and Anticancer Activities
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Nutrition and Health in Aging
- Meningioma and schwannoma management
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Economic and Financial Impacts of Cancer
- Edcuational Technology Systems
- Viral gastroenteritis research and epidemiology
- Health and Education Studies
- Mental Health and Well-being
- Computer Science and Engineering
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2013-2023
University of Indonesia
2013-2023
PURPOSE In 2016, there were 1,308,061 cases of cancer being treated in Indonesia, with 2.2 trillion rupiahs spent, amounting to $486,960,633 US dollars (purchasing power parity 2016). The high burden cancers Indonesia requires a valid data collection inform future cancer-related policies. purpose this study is report epidemiological from 2008 2012 based on Hospital-Based Cancer Registry (HBCR) Cipto Mangunkusumo Hospital, Indonesia. METHODS This was descriptive cross-sectional design. Data...
BACKGROUND Diffusion-weighted magnetic resonance imaging (DW-MRI) is a noninvasive, non-contrast sequence for cancer detection. Research involving DW-MRI in cervical has revealed lower apparent diffusion coefficient (ADC) values. This study aimed to evaluate the difference tumor ADC values and ratios (tumor-to-urine tumor-to-muscle) with respect staging (early versus late) histopathology (squamous cell carcinoma adenocarcinoma). METHODS retrospective included 56 patients cancer, divided into...
BACKGROUND Cancer is a complex disease requiring multidisciplinary approach in establishing prompt diagnosis and treatment. Treatment timely manner crucial for the outcomes. Hence, this study aimed to provide information on treatment delay including patient provider delays its associated factors. METHODS patients were recruited conveniently outpatient clinic of Department Radiation Oncology, Cipto Mangunkusumo Hospital, Indonesia between May August 2015. All asked fill questionnaire...
Cancer stem cells are involved in radioresistant cancers. Transcription factors Sry-related HMG box (SOX2) and octamer binding transcription factor 4 (OCT4) can confer pluripotent cell characteristics self-renewal ability carcinogenesis, metastasis, tumor recurrence, resistance to therapy. Apoptosis, DNA repair, telomerase also contribute radioresistance. We sought identify the role of SOX2 OCT4 as cancer markers their effects on apoptosis (via caspase 3), repair (Chk1) (hTERT) conferring...
ALDH1 is a cervical cancer stem cell marker that has radioresistance profile. Recurrence and metastasis following radiotherapy are still being problems of most patients. This study aimed to determine the correlation between response in stage III squamous carcinoma (SCCC) cervix.A total 58 360 patients SCCC who received external beem radiation brachytherapy (2016-2021) at Cipto Mangunkusumo Hospital met eligibility criteria this study. Pre- post-irradiation MRI examinations ALDH expression...
Chemoradiation is the standard therapy for advanced stages of cervical cancer. In developing countries, where 80% cancers occur, this not always available. Carbogen breathing and oral nicotinamide (CON) therapy, aimed at overcoming tumor hypoxia, has shown to improve treatment efficacy in some epithelial tumors. This study investigates effect CON during (chemo)radiation cancer on overall survival, local regional control, toxicity.From December 2006 February 2010, 139 patients with stage IB2...
BACKGROUND: It has not been well understood whether the quality and quantity of protein intake could affect life. Quality life is associated with nutritional status, but usage prognostic index (PNI) to reflect head neck cancer patients undergoing radiotherapy also still widely studied.METHODS: A cross sectional study was performed in 61 patient radiotherapy. The were obtained using semiquantitative food frequency questionnaire (FFQ) which analized by analyzed Nutrisurvey 2007, PNI a...
Cervical cancer is a leading cause of death among women worldwide, particularly in Indonesia. The main treatment advanced-stage cervical radiation; however, the outcomes do not meet required expectations. [1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione] has been reported several studies for its potency therapy. This study aims to investigate clinical and molecular [(malondialdehyde (MDA) NF-κB levels] effects, apoptotic index, safety Biocurcumin (BCM-95) as radiosensitiser...
BACKGROUND: According to the World Health Organization reports in 2020, cancer was second leading cause of death developing countries following cardiovascular diseases and infections. As one strategies prioritize control Indonesia, it is crucial establish a population-based registry, thus necessitating well-recorded study with robust methodology documentation reporting profile. AIM: This aims describe profile Jakarta based on data from Cipto Mangunkusumo Hospital as registry center for...
Background: Nasopharyngeal carcinoma (NPC) remains as a health burden in Indonesia. It is one of most common cancers Indonesia, with an overall incidence estimated at 6.2/100,000 or 12,000 new cases per year. Unfortunately, many these are unregistered due to several factors, such lack national cancer registry. In developing countries, registration often begins hospitals. Hospital-Based Cancer Registry (HBCR) provides the initial and major source information on patients that leads set-up...
Glioma adalah tumor otak yang berasal dari sel glia dan merupakan pal-ing sering terjadi yaitu 51 % dibandingkan primer lain Astrositoma tipe tersering glioma dengan frekuensi >75%. terbagi dua menjadi low grade (LGG) high (HGG). High atau disebut pula malignant mengalami pertumbuhan cepat walaupun jarang metastasis ke luar SSP. Glioblastoma multiforme (GBM) diklasifikasikan sebagai HGG WHO IV, kejadian sekitar 75 HGG. Dan umumnya pada usia dewasa angka harapan hidup glioblastoma hanya 12-15 bulan.
Kanker kolorektal masih merupakan salah satu masalah kesehatan di dunia. Beberapa studi terdahulu melaporkan adanya hubungan antara pemanjangan waktu terapi dengan penurunan kontrol lokal, namun studi-studi tersebut dilakukan pada kasus-kasus keganasan organ lain. Untuk mengetahui profil pasien kanker rektum Departemen Radioterapi RS Cipto Mangunkusumo dan faktor-faktor yang mempengaruhi keberhasilan terapi, maka penelitian ini. Penelitian bersifat retrospektif deskriptif analitik, terhadap...
Background: Global Burden of Cancer 2012 (GLOBOCAN 2012) estimated 14.1 million new cases cancer worldwide in 2012. This data was obtained from countries that have a population-based registry. registration is useful classifying information all to generate statistics incidence particular population as well providing framework for interpreting and controlling the impact community. Indonesia has not had registry currently. The Minister Health designated Dr. Cipto Mangunkusumo Hospital control...
Immunotherapy is a developing field in cancer treatment. using immune checkpoint inhibitors has been successful treating patients with metastatic disease, as well who are refractory to standard treatments. Although immunotherapy yielded considerably positive outcomes, its clinical benefits limited small subset of patients. A combination radiotherapy and shown provide greater more Radiation, particularly hypofractionated radiation stereotactic radiosurgery or body radiotherapy, works by...
Toksisitas akut radiasi merupakan suatu proses yang diawali dengan kerusakan sel normal. Malondialdehyde (MDA) produk akhir dari peroksidasi lipid biomarker stres oksidatif. Catalase (CAT) adalah antioksidan enzimatik mengkatalisis H2O2 menjadi air dan oksigen. Penelitian ini bertujuan untuk mengetahui apakah kadar MDA aktivitas CAT dapat dijadikan prediktor derajat toksisitas pada kanker serviks stadium lanjut lokal. studi kohort prospektif terhadap 30 pasien lokal memenuhi kriteria inklusi...
Cancer has caused a tremendous burden in developing countries. Oncolytic virus (OV) therapy is an emerging modality with the potential to be single or combination agent radiation (RT). Following entry of OV cell, will replicate and assemble before exiting from tumor cells. Construction can done by modifying capsid, genome, chemical material viruses. Irradiation induce double-strand breaks, further integration DNA damage response pathway interact MRE11-Rad50-Nbs1 complex regulate mobilization...
Background : Cervical cancer ranks in the second place based on malignancy among female sex Indonesia with a prevalence of 14.4% and mortality rate 10.3%. Hospital-Based Cancer Registry (HBCR) is system registration hospital that can provide information about general patients, treatment, outcome treatment. This study was conducted to obtain profile cervical dr. Cipto Mangunkusumo (RSCM) 2013 data from HBCR RSCM. Methods The by extracting epidemiological tumor RSCM which then analyzed...
One of the expected elimination pathways cancer cells in process radiation is apoptosis. Nuclear factor kappa-B (NFkB) a transcription related to mechanism apoptosis resistance cell, which can affect post-radiation response. The aim this study assess relative expression NFkB locally advanced cervical and its relation radiotherapy was conducted with observational cohort design on January-October 2015. Pre-radiotherapy biopsy specimen collected from 17 subjects, while only 10 subjects were...