A5014878219- Nutrition and Health in Aging
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Public Health and Nutrition
- Epigenetics and DNA Methylation
- COVID-19 and healthcare impacts
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Inflammatory Biomarkers in Disease Prognosis
- Head and Neck Anomalies
- Parathyroid Disorders and Treatments
- Fibroblast Growth Factor Research
- Nutritional Studies and Diet
- Global Health and Surgery
- Tannin, Tannase and Anticancer Activities
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2018-2025
University of Indonesia
2000-2025
Dharmais Cancer Hospital
2014
PURPOSE In 2016, there were 1,308,061 cases of cancer being treated in Indonesia, with 2.2 trillion rupiahs spent, amounting to $486,960,633 US dollars (purchasing power parity 2016). The high burden cancers Indonesia requires a valid data collection inform future cancer-related policies. purpose this study is report epidemiological from 2008 2012 based on Hospital-Based Cancer Registry (HBCR) Cipto Mangunkusumo Hospital, Indonesia. METHODS This was descriptive cross-sectional design. Data...
BackgroundComplementary medicine, which refers to therapies that are not part of conventional comprising both evidence-based and non-evidence-based interventions, is increasingly used following a diagnosis cancer. We aimed investigate out-of-pocket spending patterns on complementary medicine its association with adverse financial outcomes cancer in middle-income countries southeast Asia.MethodsIn this prospective cohort study, data newly diagnosed patients were derived from the ASEAN Costs...
Background This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index breast cancer. Method is a multicenter case-control conducted in six public referral hospitals Indonesia. Cases are individuals aged 19 years or above who were diagnosed with cancer within 1 year of diagnosis, based on histopathology immunohistochemistry. Controls recruited from corresponding hospitals. TyG was determined by formula: ln (fasting TG [mg/dl] × fasting glucose...
Abstract Background Squamous cell carcinoma of the oral cavity (OSCC) is sixth most common malignancy. Surgery mainstay treatment for cancers. in locally advanced OSCC presents many challenges primarily because head and neck have critical structures that can be damaged by tumor or treatment. It thought neoadjuvant chemotherapy (NC) able to shrink size. Chemoresistancy a problem due hypoxic microenvironment characterized increased expression HIF-1α. also regulated miR-210 as well CD44 CD133....
Breast cancer is the most common with an increasing incidence in Asia. About 20% of all breast cancers are triple-negative (TNBCs). BCSC a subset tumor cells that has stem cell-like characteristics, such as high capacity for self-renewal and initiation, which implies may cause aggressiveness TNBC. ALDH1 role early cell differentiation through its function oxidation retinol to retinoic acid, proposed be strong candidate cells. Various studies have shown one markers CSC can used prognosis...
Abstract Background Triple-negative breast cancer (TNBC) has been documented as the most aggressive subtype of cancer. This study aimed to analyze antitumor and protumor immune activities, their ratios significant prognostic biomarkers in metastatic TNBC (mTNBC). Methods A multicenter cohort was conducted among 103 de novo mTNBC patients. The expression CD8 CD163 evaluated using immunohistochemistry staining, CD4 FOXP3 double-staining immunohistochemistry, PD-L1 RT-PCR. Results Multivariate...
Breast cancer subtypes can be categorized based on their gene expression profiles using immunohistochemistry into Luminal A, B, human epidermal growth factor receptor 2-positive (HER2+), and triple-negative breast (TNBC) subtypes. However, has certain limitations that lead to misclassification. DNA methylation is an epigenetic modification, changes in the promoter region alter quantity of functional protein synthesized, disrupting function. The aim this study was identify biomarkers for...
Background: The LYMPH-Q Upper Extremity module is a patient-reported outcome measurement tool developed by the Q-Portfolio team at McMaster University, Canada, and widely used to determine health-related quality of life patients with upper extremity lymphedema. However, translation these tools Indonesian language has not been attempted any institution. Methods: was performed according International Society Pharmacoeconomics Outcomes Research guidelines. steps included forward reconciliation,...
Background: The BRCA1/2 mutation rate was found to be higher in triple-negative breast cancer (TNBC) patients depending on young age, and the presence of a family history ovarian cancer. Research germline mutations that focused premenopausal TNBC Indonesia has never been carried out. objective this research is determine gene status West Sumatra.Methods: This descriptive study conducted at Surgical Oncology Division DR. M. Djamil Hospital, Padang from April July 2023. included aged 50 years...
Background: Breast cancer is a type of malignancy with the highest number cases in world and Indonesia. The C-reactive protein-albumin ratio (RCA) simple, feasible, objective breast serum marker representing inflammatory nutritional status. There are not many studies regarding relationship between RCA metastasis, especially advanced-stage case population Indonesia.Method: Study cross-sectional design 180 patients stage III IV at Cipto Mangunkusumo Hospital, who were diagnosed 2018 until...
Background: The BREAST-Q reconstruction module, a patient-reported outcome measurement tool, is widely used to assess the impact of breast surgery on patient satisfaction and health-related quality life. However, translation Indonesian language has not been attempted or for Indonesian-speaking women with cancer. Methods: module was performed in accordance International Society Pharmacoeconomics Outcomes Research guidelines, which included forward reconciliation, back review, cognitive...
Background: Breast reconstruction in women with breast cancer has not been thoroughly investigated or measured Indonesia. A pioneering study is needed to identify the rate, treatment outcomes, and factors influencing a smaller population support nationwide epidemiological studies future. Methods: The secondary data of 105 who underwent post-breast surgery at several centers Jakarta were collected retrospectively from 2020—the first quarter 2024. Univariate bivariate analyses subsequently...
BRAFV600E and RAS mutations are the most common gene in papillary thyroid carcinoma (PTC) that may be correlated with its biological behavior. There still limited data about Indonesia. This study aims to determine prevalence of mutations, their association clinicopathologic characteristics.Patients who had total thyroidectomy from 2019 2021 those met our criteria underwent PCR DNA sequencing analysis for BRAFV600E, BRAFK601E, exon 2 3 NRAS, HRAS, KRAS. Analyses were performed associations...
BACKGROUND Cancer is a complex disease requiring multidisciplinary approach in establishing prompt diagnosis and treatment. Treatment timely manner crucial for the outcomes. Hence, this study aimed to provide information on treatment delay including patient provider delays its associated factors. METHODS patients were recruited conveniently outpatient clinic of Department Radiation Oncology, Cipto Mangunkusumo Hospital, Indonesia between May August 2015. All asked fill questionnaire...
Chemoresistance is a major issue in patients with locally advanced oral squamous cell carcinoma (OSCC). In this study, we evaluated the effectiveness of melatonin conjunction neoadjuvant chemotherapy (NC) on hypoxia-inducible factor-1α (HIF-1α) expression and clinical response OSCC patients.To study effects HIF-1α its effect OSCC.A randomized controlled trial was conducted, wherein were recruited from several hospitals Jakarta, Indonesia. Patients into two groups using computerized block...
•Type of Research: Single-center retrospective cohort study•Key Findings: Immediate supermicrosurgery lymphatic reconstruction is technically feasible after ALND, with the 1-year and 2-year BCRL rate being 14% (95% CI 4.0-23.9%) 22% 10.1-33.9%), respectively.•Take Home Message: In breast cancer patients who have immediate technique a surgical for primary prevention BCRL, although comparison control group long-term follow-up should be elaborated to confirm effectiveness. ObjectiveTo describe...
A thyroglossal duct cyst is a lesion that occurs as result from failure of the to obliterate during fetal development. Malignant progression rare event might occur in less than 1% all cases. Because its rarity, there are conflicting opinions regarding management case. In present study, 46-year-old male presented with painless neck mass had increased size over last 6 months. There was no difficulty swallowing and breathing, change voice, significant weight loss, or any signs hyperthyroidism....
Abstract Approximately 60%–70% of breast cancer patients in Indonesia are diagnosed the locally advanced stage. The stage carries a higher risk lymph node metastasis which increases susceptibility to obstruction. Hence, cancer‐related lymphedema (BCRL) could present before axillary dissection (ALND). purpose this case report is describe immediate‐delayed lymphatic reconstructions with lymphaticovenous anastomosis two subclinical cases that ALND. There were 51 and 58 years old IIIC IIIB,...
BACKGROUND: Amino acids are important for proliferation and maintenance of tumor cells. Breast cancer patients were found to have significant changes in the number amino acids, which assumed be correlated with molecular subtypes breast cancer. Therefore, current study was conducted analyze plasma luminal A B subtypes.METHODS: control subjects recruited, venous blood collected measurement acids. Total 19 measured using reverse-phase high-performance liquid chromatography C18 column. Mean...
Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity hyperparathyroidism. It consists fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic brown-colored result hemosiderin deposition into osteolytic cysts. Two cases young women aged 26 29 years old, respectively, are known with history end-stage renal disease (ESRD). Dialysis performed two times/week over last 7 years. Our patients presented an intraoral mass...
Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END).The purpose of the study was determine association between CYP2D6*10 (c.100C>T) genotype and attainment plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women cancer.A cross-sectional performed 125 ambulatory consuming TAM at 20 mg/day least 4 months. The frequency distribution genotypes...