A5101981162- Membrane Separation Technologies
- Enzyme Catalysis and Immobilization
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- DNA and Nucleic Acid Chemistry
- Supramolecular Self-Assembly in Materials
- Ionic liquids properties and applications
- Membrane Separation and Gas Transport
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Membrane-based Ion Separation Techniques
- Electrochemical sensors and biosensors
- Lipid Membrane Structure and Behavior
- Advanced Sensor and Energy Harvesting Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- Protein Interaction Studies and Fluorescence Analysis
- Chemical Synthesis and Analysis
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Molecular Junctions and Nanostructures
- Nanofabrication and Lithography Techniques
- Enzyme-mediated dye degradation
- Biochemical and Molecular Research
- Glycosylation and Glycoproteins Research
- Surface Modification and Superhydrophobicity
Kobe University
2016-2025
Kyushu University
2002-2021
Graduate School USA
2014-2021
Kumamoto University
1987-2015
Tokushima Bunri University
1990-2007
Japan Science and Technology Agency
2004-2005
Japan Society for the Promotion of Science
2005
The University of Tokyo
2000-2003
Food Research Institute
2000-2002
Food Research Institute
2001
We report cancer cell death initiated by the intracellular molecular self-assembly of a peptide lipid, which was derived from gelator precursor. The precursor designed to form nanofibers via self-assembly, after cleavage cancer-related enzyme (matrix metalloproteinase-7, MMP-7), leading hydrogelation. exhibited remarkable cytotoxicity five different lines, while low normal cells. Cancer cells secrete excessive amounts MMP-7, converted into supramolecular prior its uptake Once inside cells,...
Extraction of rare earth metals into ionic liquids (ILs) from aqueous solutions was investigated using octyl(phenyl)-N,N-diisobutylcarbamoylmethyl phosphine oxide (CMPO) as an extractant. Use ILs greatly enhanced the extraction efficiency and selectivity CMPO for metal ions compared to when n-dodecane used extracting solvent. The mechanism has been studied by slope analysis tests, these confirmed that proceeds via a cation-exchange mechanism. Furthermore, stripping phase complexing agents...
Organelle targeting is a useful approach in drug development for cancer therapy. Peptide amphiphiles are good candidates specific organelles because they can be engineered into wide range of molecular structures, enabling customization functional needs. We have developed peptide amphiphile, C16‐(EY)3, that respond to tyrosine kinase activity and undergo phosphorylation inside cells. C16‐(EY)3 selectively induced apoptosis cells overexpressed kinase. The amphiphile self‐assembled nanofibers...
A three-phase flow, water/n-heptane/water, was constructed in a microchannel (100-μm width, 25-μm depth) on glass microchip (3 cm × 7 cm) and used as liquid membrane for separation of metal ions. Surface modification the by octadecylsilane groups induced spontaneous phase flow microfluidic device, which allows control interfacial contact time off-chip analysis using conventional analytical apparatus. Prior to selective transport ion through microchannel, forward backward extraction yttrium...
Background.p -Cresyl sulfate (PCS), a recently identified anionic uremic toxin, is the main circulating metabolite of p -cresol. In cases chronic kidney disease (CKD), it might be associated with cardiovascular outcomes and progression CKD. However, renal excretion pathway PCS currently unknown. The objective present study was to determine whether organic anion transporters (OATs), which are tubular basolateral membrane transporters, play an important role in this process. Methods. uptake...
We developed novel supramolecular gelators with simple molecular structures that could harden a broad range of solvents: aqueous solutions wide pH range, organic solvents, edible oil, biodiesel, and ionic liquids at gelation concentrations 0.1-2 wt %. The were composed long hydrophobic tail, amino acids gluconic acid, which prepared by liquid-phase synthesis. Among seven types the synthesized, containing L-Val, L-Leu, L-Ile exhibited high ability to various solvents. These soluble in also...
Self-assembly of synthetic molecules has been drawing broad attention as a novel emerging approach in drug discovery. Here, we report selective cell death induced by peptide amphiphile that self-assembles to form entangled nanofibers (hydrogel) based on intracellular pH (pHi). We found palmitoylated hexapeptide (C16-VVAEEE) formed hydrogel below 7. The formation the nanofibrous self-assembly was responsive small change around cytotoxicity C16-VVAEEE correlated with pHi cells. Microscope...
Enzymatic degradation of p-chlorophenol was carried out in a two-phase flow microchannel (100 µm width, 25 depth) fabricated on glass plate (70 mm × 38 mm). This is the first report enzymatic reaction microfluidic device. The surface partially modified with octadecylsilane groups to be hydrophobic, thus allowing clear phase separation at end-junction microchannel. enzyme (laccase), which active, solubilized succinic aqueous buffer and substrate (p-chlorophenol) isooctane. occurred mainly...