A5101668400- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Genomics and Chromatin Dynamics
- Crystallography and molecular interactions
- Circadian rhythm and melatonin
- Optimism, Hope, and Well-being
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Nutrition, Genetics, and Disease
- Glycosylation and Glycoproteins Research
- Digestive system and related health
- Cognitive Abilities and Testing
- Mental Health Research Topics
Kobe University
2022-2025
Yamaguchi University
2022
Kindai University
2010-2013
Organelle targeting is a useful approach in drug development for cancer therapy. Peptide amphiphiles are good candidates specific organelles because they can be engineered into wide range of molecular structures, enabling customization functional needs. We have developed peptide amphiphile, C16‐(EY)3, that respond to tyrosine kinase activity and undergo phosphorylation inside cells. C16‐(EY)3 selectively induced apoptosis cells overexpressed kinase. The amphiphile self‐assembled nanofibers...
Cell-selective killing using molecular self-assemblies is an emerging concept for cancer therapy. Reported are triggered by hydrolysis of well-designed molecules inside or outside cells. This can occur in and normal cells because the abundance water living systems. Here, we report situ synthesis a self-assembling molecule tyrosine kinase overexpressed We designed tyrosine-containing peptide amphiphile (C16-E4Y) that transformed into phosphorylated (C16-E4pY) kinase. Phosphorylation C16-E4Y...
After fertilization, the sperm and oocyte genomes undergo extensive epigenetic reprogramming to form a totipotent zygote. The dynamic changes during early embryo development primarily involve DNA methylation demethylation. We have previously identified Gse (gonad-specific expression gene) be expressed specifically in germ cells embryos. Its encoded protein GSE is predominantly localized nuclei of from zygote blastocyst stages, suggesting possible roles occurring development. Here, we report...
Degradation of maternally stored mRNAs after fertilization is an essential process for mammalian embryogenesis. Maternal mRNA degradation depending on deadenylases in early embryos has been mostly speculated, rather than directly demonstrated. Previously, we found that gene expression nocturnin, which functions as a circadian clock-controlled deadenylase cells, was clearly changed during the maternal-to-zygotic transition (MZT). Here, investigated possible role nocturnin mouse MZT. First,...
We have examined the role of Fam60a, a gene highly expressed in embryonic stem cells, mouse development. Fam60a interacts with components Sin3a-Hdac transcriptional corepressor complex, and most Fam60a–/– embryos manifest hypoplasia visceral organs die utero. is recruited to promoter regions subset genes, expression these genes being either up- or down-regulated embryos. The DNA methylation level target Adhfe1 maintained at day (E) 7.5 but markedly reduced E9.5 embryos, suggesting that...
Germ cells are the only that possible to communicate next generation and having pluripotency. In development of primordial germ (PGCs), specific molecular mechanisms such as epigenetic regulation signal transduction involved. Recently, several reports have showed PGCs expression genes essential for mutants lack normal development. We identified novel gene named GSE (gonad gene), which expressed at ovary testis adult mice. Subsequently, we isolated a GIAP (GSE-interacting protein), by yeast...