Christen L. Ebens
A5037348152- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Skin and Cellular Biology Research
- Cytomegalovirus and herpesvirus research
- Autoimmune Bullous Skin Diseases
- Blood disorders and treatments
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- DNA Repair Mechanisms
- Virus-based gene therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cellular Mechanics and Interactions
- Immune Cell Function and Interaction
- Dermatological and Skeletal Disorders
- Porphyrin Metabolism and Disorders
- Telomeres, Telomerase, and Senescence
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- Renal Transplantation Outcomes and Treatments
- Wound Healing and Treatments
- Autoimmune and Inflammatory Disorders Research
- Blood groups and transfusion
- CAR-T cell therapy research
University of Minnesota
2016-2025
University of Minnesota Medical Center
2016-2024
Fairview Health Services
2021-2024
University of Minnesota Children's Hospital
2020-2023
Minneapolis Institute of Arts
2021
University of Minnesota System
2020
University of Michigan
2013-2017
Cohort (United Kingdom)
2014
Pediatrics and Genetics
2013
University of Illinois Chicago
2006
Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation. Current strategies to control GVHD rely on global immunosuppression. These are incompletely effective and decrease anticancer activity graft. We previously identified Notch signaling in T cells as a new therapeutic target for preventing GVHD. Notch-deprived showed markedly decreased production inflammatory cytokines, but normal vivo proliferation, increased accumulation regulatory cells,...
Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) ligands has emerged as major regulator GVHD pathogenesis, little is known about the timing essential signals and cellular source after allo-BMT. Here, we have shown that critical DLL1/4-mediated are delivered to donor cells during short 48-hour window in mouse allo-BMT model. Stromal, but...
Abstract Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral prior studies. We performed phase II multicenter study (NCT03475212) the patients with inborn errors immunity and/or post allogeneic hematopoietic stem transplant using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus. Primary endpoints were feasibility, safety, clinical...
BACKGROUNDRecessive dystrophic epidermolysis bullosa (RDEB) is a rare, devastating, and life-threatening inherited skin fragility disorder that comes about due to lack of functional type VII collagen, for which no effective therapy exists. ABCB5+ dermal mesenchymal stem cells (ABCB5+ MSCs) possess immunomodulatory, inflammation-dampening, tissue-healing capacities. In Col7a1-/- mouse model RDEB, treatment with MSCs markedly extended the animals' lifespans.METHODSIn this international,...
Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, incurable blistering skin disease caused by biallelic mutations in type VII collagen (C7). Advancements treatment of RDEB have come from harnessing the immunomodulatory potential mesenchymal stem cells (MSCs). Although human bone marrow-derived MSC (BM-MSC) trials demonstrate improvement clinical severity, mechanisms migration to and persistence injured their contributions wound healing are not completely understood. A...
Fanconi anemia (FA)-associated severe aplastic (SAA) requires allogeneic hematopoietic cell transplantation (HCT) for cure. With the evolution of conditioning regimens over time, outcomes alternative donor HCT (AD-HCT) have improved dramatically. We compared HLA-matched sibling (MSD-HCT; n = 17) and AD-HCT (n 57) performed FA-associated SAA at a single institution between 2001 2016. Overall survival 5 years was 94% MSD-HCT versus 86% AD-HCT, neutrophil engraftment 100% 95%, platelet recovery...
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe systemic genodermatosis lacking therapies beyond supportive care for its extensive, life‐limiting manifestations. To report the safety and preliminary responses of 10 patients with RDEB to bone marrow transplant (BMT) post‐transplant cyclophosphamide (PTCy BMT) after reduced‐intensity conditioning infusions immunomodulatory donor‐derived mesenchymal stromal cells (median follow‐up 16 months). BMT toxicities, donor blood skin...
Allogeneic hematopoietic cell transplantation (HCT) can be curative for many inborn errors of immunity (IEI). Timely neothymopoiesis is paramount to favorable clinical outcomes after HCT. Neothymopoiesis quantified by flow cytometric measurement circulating recent thymic emigrants (RTE; CD31+CD4+CD45RA+ T cells). We hypothesized that decreased RTE would associated with baseline HCT characteristics older age at time and exposure greater conditioning intensity, as well including mixed (<95%)...
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine (1,2) and loss-of-function mutations in IL-10 or the receptor (IL-10R) have been implicated as common cause of infantile inflammatory bowel disease (IBD) (3–6). These patients typically present first months life with severe colitis, perianal disease, folliculitis, and, on occasion, arthritis, are classically refractory to various immunosuppressive agents. Hematopoietic stem cell transplantation (HSCT) has shown be curative, but not...
IL10 receptor (IL10R) deficiency causes severe infantile-onset inflammatory bowel disease. Intact IL10R-dependent signals have been shown to be important for innate and adaptive immune cell functions in mice. We previously reported a key role of the generation function human anti-inflammatory macrophages. Independent defects, aim current study was determine IL10R signaling regulating CD4 T-cell function.Peripheral blood mononuclear cells intestinal biopsies were collected from...