A5037067259- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- Malaria Research and Control
- Mathematical Biology Tumor Growth
- COVID-19 epidemiological studies
- Genetic Neurodegenerative Diseases
- Mosquito-borne diseases and control
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Stochastic processes and statistical mechanics
- Influenza Virus Research Studies
- Parasite Biology and Host Interactions
- Wheat and Barley Genetics and Pathology
- Fungal and yeast genetics research
- Complex Systems and Time Series Analysis
- Theoretical and Computational Physics
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Nonlinear Differential Equations Analysis
- Nonlinear Dynamics and Pattern Formation
- Evolutionary Game Theory and Cooperation
- Neuroscience and Neuropharmacology Research
Centre National de la Recherche Scientifique
2018-2025
Université de Montpellier
2018-2025
Université de Bordeaux
2020-2025
Allen Institute for Brain Science
2024
Institut du Cerveau
2022-2024
Sorbonne Université
2022-2023
University of Koudougou
2023
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2018-2022
Inserm
2022
Institut de Recherche pour le Développement
2018-2021
In an epidemic, individuals can widely differ in the way they spread infection depending on their age or number of days have been infected for. absence pharmaceutical interventions such as a vaccine treatment, non-pharmaceutical ( e.g . physical social distancing) are essential to mitigate pandemic. We develop original approach identify optimal age-stratified control strategy implement function time since onset epidemic. This is based model with double continuous structure terms host and...
Host age variation is a striking source of heterogeneity that can shape the evolution and transmission dynamic pathogens. Compared with vertebrate systems, our understanding impact host on invertebrate–pathogen interactions remains limited. We examined influence mosquito key life-history traits driving human malaria transmission. Females Anopheles coluzzii , major vector, belonging to three classes (4-, 8- 12-day-old), were experimentally infected Plasmodium falciparum field isolates. Our...
The Covid-19 pandemic outbreak was followed by a huge amount of modelling studies in order to rapidly gain insights implement the best public health policies. Most these compartmental models involved ordinary differential equations (ODEs) systems. Such formalism implicitly assumes that time spent each compartment does not depend on already it, which is at odds with clinical data. To overcome this “memoryless” issue, widely used solution increase and chain number compartments unique reality (...
We have modeled the evolutionary epidemiology of spore-producing plant pathogens in heterogeneous environments sown with several cultivars carrying quantitative resistances. The model explicitly tracks infection-age structure and genetic composition pathogen population. Each strain is characterized by pathogenicity traits determining its infection efficiency a time-varying sporulation curve taking into account lesion aging. first derived general expression basic reproduction number
Abstract Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene encoding Huntingtin protein (Htt). While symptoms, primarily characterized progressive deterioration of striatum and motor cognitive functions, typically manifest adulthood, recent studies have also highlighted developmental defects HD. Indeed, alterations cortical striatal development been observed individuals carrying as early embryonic stages. However, despite being one most...
Abstract In an epidemic, individuals can widely differ in the way they spread infection, for instance depending on their age or number of days have been infected for. The latter allows to take into account variation infectiousness as a function time since infection. absence pharmaceutical interventions such vaccine treatment, non-pharmaceutical ( e.g . social distancing) are great importance mitigate pandemic. We propose model with double continuous structure by host and By applying optimal...
In this article, we study the behavior of a nonlinear age-structured predator-prey model that is generalization Lotka-Volterra equations. We prove global existence, uniqueness and positivity solution using semigroup approach. make some analytically explicit thresholds ensure, or not depending their values, boundedness time asymptotic stability equilibria. The latter theoretical results limits are enlightened by simulations.
This work revisits and extends in various directions a by J.Z. Farkas P. Hinow (Math. Biosc Eng, 8 (2011) 503-513) on structured populations models (with bounded sizes) with diffusion generalized Wentzell boundary conditions. In particular, we provide first self-contained $L^{1}$ generation theory making explicit the domain of generator. By using Hopf maximum principle, show that semigroup is always irreducible regardless reproduction function. weak compactness arguments, stability result...
Related DatabasesWeb of Science You must be logged in with an active subscription to view this.Article DataHistorySubmitted: 10 May 2019Accepted: 18 June 2020Published online: 16 September 2020KeywordsLotka--Volterra equations, age-structured population, time delay, asymptotic stability, Lyapunov functional, periodic solutions, global attractivenessAMS Subject Headings34D23, 34K20, 35B40, 92D25Publication DataISSN (print): 0036-1410ISSN (online): 1095-7154Publisher: Society for Industrial...
Abstract We model the evolutionary epidemiology of spore-producing plant pathogens in heterogeneous environments sown with several cultivars carrying quantitative resistances. The explicitly tracks infection-age structure and genetic composition pathogen population. Each strain is characterized by pathogenicity traits describing its infection efficiency a time-varying sporulation curve taking into account lesion ageing. first derive general expression basic reproduction number ℛ 0 for fungal...
This work provides a general spectral analysis of size-structured two-phase population models. Systematic functional analytic results are given. We deal first with the case finite maximal size. characterize irreducibility corresponding $ L^{1} semigroup in terms properties different parameters system. also gap property semigroup. It turns out that implies existence gap. In particular, we provide criterion for asynchronous exponential growth. show how to time asymptotics lack irreducibility....
Abstract The Covid-19 pandemic outbreak was followed by a huge amount of modelling studies in order to rapidly gain insights implement the best public health policies. Most these compartmental models involved ordinary differential equations (ODEs) systems. Such formalism implicitly assumes that time spent each compartment does not depend on already it, which is at odds with clinical data. To overcome this “memoryless” issue, widely used solution increase and chain number compartments unique...
Abstract Tumor-associated macrophages and microglia (TAMs) are highly abundant myeloid cells in gliomas, with their phenotypes immune responses shaped by ontogeny microenvironment. TAMs display distinctive transcriptional programs based on the IDH status of tumors, yet underlying signaling mechanisms remain largely unknown. Herein, we uncover that CD11B+ human IDH-mutant gliomas exhibit DNA hypermethylation, predominantly at distal enhancers. This hypermethylation impairs binding core...
Abstract BACKGROUND Resident microglia are highly plastic myeloid cells. Their phenotype and immune response determined by the microenvironment composition. Although microglial cells abundant in IDH-mutated (IDHm) gliomas, how this particular environment modulates transcriptional programs cell states of these remain largely uncharacterized. Herein we investigated whether D-2HG, oncometabolite produced IDH mutation released into tumor microenvironment, impinges upon phenotypic functional...
We study a competitive infection-age structured SI model between two diseases. The well-posedness of the system is handled by using integrated semigroups theory, while existence and stability disease-free or endemic equilibria are ensured, depending on basic reproduction number $R_0^x$ $R_0^y$ each strain. then exhibit Lyapunov functionals to analyse global we prove that equilibrium globally asymptotically stable whenever $\max\{R_0^x, R_0^y\}\leq 1$. With respect explicit basin attraction,...
Huntington's disease (HD) is an inherited neurodegenerative disorder that usually starts during midlife with progressive alterations of motor and cognitive functions. The caused by a CAG repeat expansion within the huntingtin gene leading to severe striatal neurodegeneration. Recent studies conducted on pre-HD children highlight early developmental starting as soon 6 years old, earliest age assessed. These findings, in line data from mouse models HD, raise question when development do first...
Abstract BACKGROUND Tumor-associated macrophages and microglia (TAMs) are highly abundant myeloid cells in diffuse gliomas. Their composition transcriptional programs differ according to the IDH mutation status of glioma cells. The underlying mechanisms remain until now little known. MATERIAL AND METHODS We compared bulk DNA methylome (Methylation EPIC array) transcriptome TAMs (CD11b+ purified by magnetic-activated cell sorting) from 25 IDH-mutant 11 IDH-wildtype contamination CD11b+...