A5070586291- Ovarian function and disorders
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Toxic Organic Pollutants Impact
- Cancer Risks and Factors
- Nutrition and Health Studies
- Effects and risks of endocrine disrupting chemicals
- Thyroid Disorders and Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Biology and Fertility
- Menopause: Health Impacts and Treatments
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Cardiovascular Disease and Adiposity
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Per- and polyfluoroalkyl substances research
- Regulation of Appetite and Obesity
- Cardiac Valve Diseases and Treatments
- Lipid metabolism and disorders
Jagiellonian University
2015-2024
John Paul II Hospital
2016
Children's Clinical University Hospital
2005
Uniwersytecki Szpital Dziecięcy
2005
CARE Fertility
2003
The type of diet not only affects the composition oral microflora but is also one more critical factors associated with an increased risk Parkinson's disease, PD. This study compared preferences and microbiota profiles in patients PD vs. healthy controls. 59 108 controls (without neurodegeneration) using 16S rRNA gene amplicon sequencing. According to results, different from In particular, decreased abundance Proteobacteria, Pastescibacteria, Tenercutes was observed. cavity characterized by...
Recent animal studies have indicated possible reproductive endocrine effects of levetiracetam (LEV). The aim the present study was to investigate LEV compared valproate (VPA) using human ovarian follicular cells.Cell cultures granulosa cells were prepared. First, effect drugs on basal and follicle-stimulating hormone (FSH)-stimulated estradiol secretion investigated at different concentrations (12, 20, 50, or 80 microg/ml) VPA (75, 100, 250, 350 microg/ml). Second, CYP19 aromatase activity...
Gut microbiome and colonic inflammation can be associated with the predisposition progression of Parkinson's disease (PD). The presented study aimed to compare gastrointestinal microbiota composition between patients diagnosed PD treated only Levodopa healthy controls. In this prospective study, were recruited in 1 academic hospital from July 2019 2020. detailed demographic data medical history collected using a set questionnaires. Fecal samples obtained all participants. Next-Generation...
Polycystic ovary syndrome (PCOS) affects 4-18% of women reproductive age. The number reports exploring the lipid profiles among PCOS patients and studied are limited. aim our study was to assess profile separately in lean non-lean with polycystic divided according hyperandrogenemia, defined as free androgen index (FAI)≥5. second compare respect hyperandrogenemia regularity menstruation cycles. We evaluated 232 from Department Endocrinological Gynecology, Jagiellonian University Medical...
Previously, we demonstrated the expression of apelin and G-protein-coupled receptor APJ in human placenta cell lines as well its direct action on proliferation endocrinology. The objective this study was to examine effect apoptosis BeWo cells villous explants from third trimester pregnancy. were incubated with (2 20 ng/mL) alone or staurosporine for 24 72 h. First, analysed dose- time-dependent apoptotic factors mRNA level by real-time PCR protein using Western blot. Next, checked caspase 3...
Abstract Background Hyperandrogenism is among the most common endocrine disorders in women. Clinically, it manifests as hirsutism, acne, and alopecia. A healthy lifestyle, including nutritious dietary patterns physical activity, may influence clinical manifestation of disease. This study determined effect a low-glycemic index anti-inflammatory diet on testosterone levels sex hormone-binding globulin (SHBG) symptoms hyperandrogenic women at their reproductive age. Methods The included 44...
O bjectives:To determ ine and com pare the prevalence o f insulin resistance carbohydrate metabolism param eters in wom en with endometrial pathology. Material M ethods: 100 perim enopausal abnormal uterine bleeding and/or abnorm al endometriumw ere included into study, H ystero sco p y b iop sy w as perform ed, The study population divided four groups according to histopathological results endometrium: non-atypical hyperplasia, polyp, cancer, controls, Fasting glu co se levels OGTT, IR...
Despite the strong preclinical rationale, there are only very few data considering utility of metformin as a potential pain therapeutic in humans. The aim this study was to determine association between therapy and pressure threshold (PPT) lean women with polycystic ovary syndrome (PCOS). We hypothesized that PCOS increases PPT.Twenty-seven free androgen index phenotype >5 18 healthy controls were enrolled study. Fifteen randomly assigned be treated 1,500 mg daily for 6 months. PPT plasma...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Milewicz T, Mrozińska S, Szczepański W, et al. Dysgerminoma and gonadoblastoma in the course of Swyer syndrome. Polish Journal Pathology. 2016;67(4):411-414. doi:10.5114/pjp.2016.65876. APA Milewicz, T., Mrozińska, S., Szczepański, W., Białas, M., Kiałka, & Doroszewska, K. (2016). Pathology, 67(4), 411-414. https://doi.org/10.5114/pjp.2016.65876 Chicago Tomasz, Sandra Wojciech Magdalena Marta Katarzyna Monika...
Objective. Women who develop GDM present a metabolic condition similar to that found in type 2 diabetes, characterized by impaired insulin response. Due pathophysiologic mechanisms between 2DM and GDM, there is great interest finding markers will lead the understanding of possible common origin both diseases. The aim this study was determine serum FGF21 levels its correlation with selected parameters. Method. included 54 patients 52 nondiabetic individuals (control group 1) as well 74 women...
AbstractThe aim of the study was to evaluate potential human breast cancer tissue secrete growth hormone (GH) ,insulin-like factor I (IGF-I) and prolactin in response 10−7 M progesterone stimulation. Explants were divided according estrogen receptor (ER)/progesterone (PR) phenotype (ER(−)PR(−); ER(+)PR(−); ER(+)PR(+); ER(−)PR(+)). Our results show distinct differences cultured responses stimulation with regard secretion proliferative agents such as GH ,IGF-I prolactin. All but ER(−)PR(−)...
<b>Aim:</b> The evaluation the β-endorphin plasma levels in lean women with polycystic ovary syndrome as well without this disorder. associations between β-endorphins and other laboratory parameters were also investigated. <b>Materials methods:</b> 31 lean, defined normal range body mass index, 15 16 disorder included to study. In all patients level of was measured. Also diagnostic profile including hormone assessment made patients. <b>Results:</b> There significant differences 2 groups....
Explants of human placental tissue harvested immediately after expulsion were used to determine differences between accumulation 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated dibenzo-p-dioxin (PCDD)-polychlorinated dibenzo-p-furans (PCDF) environmental mixture, their influence on steroidogenesis. cultured in vitro for 5 days media supplemented each day with either TCDD or a mixture PCDD-PCDF. Media collected every steroid content analysis by radioimmunoassay. At 24 h the...
Explants of human placenta were used to study the effects two isomers DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) [p,p′-DDT and o,p′-DDT] their DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) metabolites [p,p′-DDE o,p′-DDE] on secretion progesterone chorionic gonadotropin (hCG). treated with 1, 10, 100 or 1000 ng/ml each compound for 24 h 72 h. We found opposite (stimulatory after short-term inhibitory long-term exposure) all compounds secretion. However, both short- exposure...