A5086722812- Inflammatory Bowel Disease
- Microscopic Colitis
- Animal Nutrition and Physiology
- Gut microbiota and health
- Diet and metabolism studies
- Liver Diseases and Immunity
- Livestock and Poultry Management
- Probiotics and Fermented Foods
- Clinical Nutrition and Gastroenterology
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Click Chemistry and Applications
- Cancer-related gene regulation
- Meat and Animal Product Quality
- Tendon Structure and Treatment
- Chemical Synthesis and Analysis
- Diverticular Disease and Complications
- Cancer-related molecular mechanisms research
- Insect Utilization and Effects
- Pregnancy and Medication Impact
- Cholesterol and Lipid Metabolism
- Food Security and Socioeconomic Dynamics
- Oral Health Pathology and Treatment
University of Kentucky
2022-2025
University of Alabama in Huntsville
2020-2024
Tennessee State University
2016-2021
The research involving the beneficial aspects of amino acids being added to poultry feed pertaining performance, growth, intake, and conversion ratio is extensive. Yet currently effects on gut microbiota aren’t fully understood nor have there been many studies executed in explain relationship between microbiota. overall outcome health has linked bird due functionality gastrointestinal tract (GIT) for digestion/absorption nutrients as well immune response. These essential functions GI are...
ABSTRACT Background Mitochondrial (Mito) dysfunction in IBD reduces mucosal O2 consumption and increases delivery to the microbiome. Increased enteric promotes blooms of facultative anaerobes (eg. Proteobacteria ) restricts obligate Firmicutes ). Dysbiotic metabolites negatively affect host metabolism immunity. Our novel compound (AuPhos) upregulates intestinal epithelial cell (IEC) mito function, attenuates colitis corrects dysbiosis humanized Il10-/- mice. We posit that AuPhos...
There are well documented complications associated with the continuous use of antibiotics in poultry industry. Over past few decades, probiotics have emerged as viable alternatives to antibiotics; however, most these candidate probiotic microorganisms not been fully evaluated for their effectiveness potential poultry. Recent evaluation a metagenome broiler chickens our laboratory revealed prevalence Lactobacillus reuteri (L. reuteri) and Actinobacteria class bacteria gastrointestinal tract....
Abstract BACKGROUND Intestinal microbial patterns of IBD patients are characterized by decreased abundance Firmicutes phylum (Walker et al., 2011, PMID: 21219646). produce short-chain fatty acids, such as acetate, butyrate, and propionate, bacterial fermentation dietary fibers, that serve >70% the energy substrate for intestinal epithelial cells (IEC) function in homeostasis (Salvi 2021, 34359944). In mammalian cells, butyrate is a signaling molecule protein posttranslational...
Abstract BACKGROUND Uncontrolled oxidative stress due to reactive oxygen species (ROS) overproduction and impaired antioxidant defense system are central IBD pathogenesis. Damaging effect of excessive ROS activates pro-inflammatory signaling pathways, compromising intestinal epithelial barrier function exacerbates existing inflammation. In the present study, we investigate underlying mechanism our previously tested mitochondria-targeted drug, AuPhos (CCC2022-24). We postulate that...
The continuous use of antibiotics is associated with many complications in the poultry industry. Probiotics have emerged as a viable alternative over past few decades to counter adverse effects antibiotics. No candidate probiotic microorganisms been fully evaluated industry for their effectiveness potential probiotics guinea fowls (GFs) compared chickens. Recently, metagenome evaluation GFs our laboratory revealed predominance Lactobacillus reuteri (L. reuteri) and actinobacteria class...
Probiotics are live microbial feed supplements that promote growth and health to the host by minimizing non-essential pathogenic microorganisms in host’s gastrointestinal tract (GIT). The campaign minimize excessive use of antibiotics poultry production has necessitated development probiotics with broad application multiple species. Design such requires understanding diversity or similarity profiles among avian species economic importance. Therefore, objective this research was establish...
Performance and efficiency of feed utilization in poultry is highly influenced by gut health, which dependent on intestinal microbial balance. Probiotics are live supplements or viable microorganisms that beneficially affect the host animal improving its gastrointestinal tract (GIT) However, their mode action suitable GIT environment favoring colonization obscure. The probiotic properties Lactobacillus plantarum, Bifidobacterium longum, Saccharomyces boulardii were evaluated. These microbes...
The mechanisms connecting obesity with type 2 diabetes, insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases remain incompletely understood. function of MAPK phosphatase-2 (MKP-2), a 1 dual-specific phosphatase (DUSP) in whole-body metabolism, how this contributes to the development diet-induced obesity, diabetes (T2D), resistance is largely unknown. We investigated physiological contribution MKP-2 metabolism whether altered human disease using knockout mice...
Abstract BACKGROUND Short-chain fatty acids (SCFAs), end-product of gut microbial metabolism, play an important role in colonic homeostasis. Butyrate is a prime SCFA that fuels intestinal epithelial cells (IECs). However, this energy source deficient inflammatory bowel disease (IBD) due to dysbiotic microbiota. In study, we posit butyrate supplementation drives mitochondrial respiration induced barrier function IBD. METHODS Normal human Colon mucosal (NCM460) were treated overnight with...
Lysine is the second limiting essential amino acid in poultry nutrition after methionine. Understanding lysine requirement of necessary guiding formulation least cost diets that effectively meet nutritional needs individual birds. The Pearl Grey guinea fowl (PGGF) not known. Therefore, objective this study was to assess appropriate levels required for optimal growth attributes PGGF. In a 12-week study, 512 one-day-old keets were weighed individually and randomly assigned electrically heated...
Proinflammatory joint environment, coupled with impeded chondrogenic differentiation of mesenchymal stromal cells (MSCs), led to inferior cartilage repair outcomes. Nuclear translocation phosphorylated-NFκB downregulates SOX9 and hinders the chondrogenesis MSCs. Strategies that minimize deleterious effects NFκB, while promoting MSC chondrogenesis, are interest. This study establishes ability continuous low-intensity ultrasound (cLIUS) preserve in a proinflammatory environment. MSCs were...
"Residual ridge resorption" (RRR) is a multifactorial condition involving bone resorption of the residual ridge. We investigated 10 single nucleotide polymorphisms (SNPs) in seven genes with aim identifying genetic factors associated RRR susceptibility. The study group included 96 patients and controls. Age at first edentulism, duration height were recorded. Saliva was collected from subjects for DNA extraction. Genotype analysis performed on 'SequenomMassARRAYiPLEX'. genotype allele...
Abstract Mitochondrial dysfunction is a characteristic feature of intestinal epithelium cells (IEC) in IBD patients, associated with oxidative stress and impaired ATP production. We posit that disrupted mitochondrial bioenergetics impairs ulcer healing IBD. In the current study, we tested novel gold-based compound (AuPhos) improves function by increasing biogenesis antioxidant enzymes IEC human colonic biopsies. METHODS: Normal epithelial (NCM460) were used to evaluate effect AuPhos on...