A5087878954- Microscopic Colitis
- Inflammatory Bowel Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Gut microbiota and health
- Health Systems, Economic Evaluations, Quality of Life
- Clostridium difficile and Clostridium perfringens research
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Coronary Interventions and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- COVID-19 and healthcare impacts
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac electrophysiology and arrhythmias
- Cancer Cells and Metastasis
- Autoimmune and Inflammatory Disorders
- Clinical Nutrition and Gastroenterology
- Cancer Research and Treatments
University of Kentucky
2023-2025
Lexington VA Health Care System
2024-2025
Inspira Medical Center Vineland
2024-2025
Health Net
2024-2025
Quaid-i-Azam University
2024
Government of Pakistan
2024
Lexington Medical Center
2024
Hospital Universiti Sains Malaysia
2024
Sultan Zainal Abidin University
2024
Michigan State University
2024
INTRODUCTION: A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy. METHODS: Patients ASUC treated upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency steroid-free clinical remission, adverse events, all-cause readmissions. RESULTS: Of the 25 upadacitinib, 6 (24%) underwent colectomy, 15 (83%) 18 available data who did not undergo...
Adverse events (AEs), such as intracranial hemorrhage, thromboembolic event, and progressive aortic insufficiency, create substantial morbidity mortality during continuous flow left ventricular assist device support yet their relation to blood pressure control is underexplored.A multicenter retrospective review of patients supported for at least 30 days ≤18 months by a from June 2006 December 2013 was conducted. All outpatient Doppler (DOPBP) recordings were averaged up the time or...
Objectives of this study were (1) to evaluate preoperative predictors systolic and diastolic heart failure in patients undergoing liver transplantation (LT) (2) describe the prognostic implications these patients. The onset after orthotopic LT remains poorly understood. Data obtained for all recipients between January 2000 December 2010. primary outcome was post-LT failure: (ejection fraction ≤ 50%), diastolic, or mixed failure. Patients underwent echocardiographic evaluation before LT....
Despite its importance in protecting the host from infections and injury, excessive inflammation may lead to serious human diseases including autoimmune disorders, cardiovascular diseases, diabetes, cancer. Exercise is a known immunomodulator; however, whether exercise causes long-term changes inflammatory responses how these occur are lacking. Here, we show that chronic moderate-intensity training of mice leads persistent metabolic rewiring chromatin accessibility bone marrow-derived...
BK virus (BKV)-associated nephropathy (BKVAN) is a major cause of renal dysfunction and graft loss in transplant recipients. Monitoring plasma viral load (BKVL) the recommended screening tool to predict BKVAN. American Society Transplantation (AST) guidelines define BKVL ≥4 log10/mL (10,000 copies) as presumptive BKVAN recommend reduction immunosuppression. We evaluated clinical sensitivity quantitative BKV DNA assay predicting risk for using AST-recommended cutoff.In retrospective,...
Clostridium difficile infection (CDI) occurs in 3-7% of liver transplant recipients (LTR). However, few data exist on the recent epidemiology, predictors and outcomes CDI LTR. A cohort study was performed including LTR from 2000 to 2010 at a tertiary care hospital Detroit. defined as diarrhea with stool C. positive test. Data analyzed included demographics, comorbidities, length stay (LOS), severity CDI, rates recurrence (<12 weeks), relapse (<4 weeks) overall mortality. Predictors were...
The epidemiology and outcomes of community-acquired pneumonia (CAP) in immunocompromised hosts (ICHs) are not well defined. objective this study was to define the CAP ICHs as compared with non-ICHs.This ancillary included a prospective cohort hospitalized adult Louisville residents from 1 June 2014 31 May 2016. An ICH defined per criteria Centers for Disease Control Prevention. Geospatial explored associations between income level, race, age. Mortality non-ICHs evaluated during...
ABSTRACT Background Mitochondrial (Mito) dysfunction in IBD reduces mucosal O2 consumption and increases delivery to the microbiome. Increased enteric promotes blooms of facultative anaerobes (eg. Proteobacteria ) restricts obligate Firmicutes ). Dysbiotic metabolites negatively affect host metabolism immunity. Our novel compound (AuPhos) upregulates intestinal epithelial cell (IEC) mito function, attenuates colitis corrects dysbiosis humanized Il10-/- mice. We posit that AuPhos...
Despite advancements in the therapeutic armamentarium for Crohn's disease (CD), biologic and small molecule monotherapies are associated with sub-optimal response remission rates. Utilizing dual therapy (DBT) holds potential to increase efficacy treatment of refractory or partially responsive CD. Evidence pertaining this strategy remains limited. We retrospectively examined CD patients treated a combination ustekinumab vedolizumab. Outcomes DBT at week (wk) 52 were compared monotherapy. The...
Abstract BACKGROUND Intestinal microbial patterns of IBD patients are characterized by decreased abundance Firmicutes phylum (Walker et al., 2011, PMID: 21219646). produce short-chain fatty acids, such as acetate, butyrate, and propionate, bacterial fermentation dietary fibers, that serve &gt;70% the energy substrate for intestinal epithelial cells (IEC) function in homeostasis (Salvi 2021, 34359944). In mammalian cells, butyrate is a signaling molecule protein posttranslational...
Abstract BACKGROUND Intestinal stem cell (ISC) homeostasis underlies signaling events that maintain the delicate balance of active self-renewal and passive differentiation. However, under certain contexts, ISC function is irreversibly compromised—requiring committed intestinal epithelial (IEC) lineages to dedifferentiate regain “stemness”. Here, we investigated underlying mechanisms involved in mucosal healing response radiation injury. METHODS The role PI3K reconstitution following injury...
Abstract BACKGROUND Uncontrolled oxidative stress due to reactive oxygen species (ROS) overproduction and impaired antioxidant defense system are central IBD pathogenesis. Damaging effect of excessive ROS activates pro-inflammatory signaling pathways, compromising intestinal epithelial barrier function exacerbates existing inflammation. In the present study, we investigate underlying mechanism our previously tested mitochondria-targeted drug, AuPhos (CCC2022-24). We postulate that...