A5079023659- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Radical Photochemical Reactions
- Fatty Acid Research and Health
- Tissue Engineering and Regenerative Medicine
- Lipid metabolism and biosynthesis
- Pluripotent Stem Cells Research
- Endodontics and Root Canal Treatments
- Dental materials and restorations
- Viral Infections and Outbreaks Research
- 3D Printing in Biomedical Research
- Oral microbiology and periodontitis research
- Click Chemistry and Applications
- Metabolism and Genetic Disorders
- Viral Infections and Vectors
- Oxidative Organic Chemistry Reactions
- Probiotics and Fermented Foods
- Mosquito-borne diseases and control
- Antimicrobial Peptides and Activities
- Drug Transport and Resistance Mechanisms
Scripps Institution of Oceanography
2020-2022
University of California, San Diego
2017-2022
University of Montana
2020
The University of Texas at Austin
2015
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class endogenous lipids with antidiabetic and anti-inflammatory activities. Interest in these is due to their unique biological activites the observation that insulin-resistant people have lower palmitic hydroxystearic (PAHSA) levels, suggesting FAHFA deficiency may contribute metabolic disease. Rigorous testing this hypothesis will require measurement many clinical samples; however, current analytical workflows too...
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin translocates to the cytosol having neutral pH where enzyme activates inflammation and cell death. active at both 7.2 of 4.6 lysosomes. We evaluated hypothesis may possess pH-dependent cleavage preferences can be utilized design selective inhibitor by (1) analysis differential profiles compared using multiplex substrate profiling mass...
CA-074 is a selective inhibitor of cathepsin B, lysosomal cysteine protease. has been utilized in numerous studies to demonstrate the role this protease cellular and physiological functions. Cathepsin B human disease mechanisms involves its translocation from acidic lysosomes pH 4.6 neutral 7.2 locations, including cytosol extracellular environment. To gain in-depth knowledge inhibition under these different conditions, study evaluated molecular features, potency, selectivity for conditions....
Thiopeptides are a class of natural products with untapped therapeutic potential. To expand the methods available for scaled production these antibiotics, we report laboratory synthesis micrococcin P1 showcasing thiazole forming reactions cysteine derivatives and nitriles followed by oxidation. In most instances, this sequence does not require chromatography proved scalable. Using approach, 199 mg was generated in single synthetic sequence.
Recently, the field of stem cell-based regeneration has turned its attention toward chemical approaches for controlling pluripotency and differentiation embryonic cells (ESCs) using drug-like small molecule modulators. Growth factor receptors or their associated downstream kinases that regulate intracellular signaling pathways during are typically targets these molecules. The glycocalyx, which plays an essential role in actuating responses to growth factors at cellular boundary, offers...
A new oxidative dearomatization reaction has been developed using phthaloyl peroxide to chemoselectively install two oxygen–carbon bonds into aromatic precursors. The oxidation proceeds only once; addition of superstoichiometric equivalents does not react further with the newly generated 1,3-cyclohexadiene. challenged by different functional groups and shown maintain chemoselectivity. Due broad reactivity 1,2-methylenedioxybenzene derivatives, linear free energy correlations were determined...
Abstract A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors heaviest microbial load, but many organs, particularly those with a mucosal surface, associate highly adapted evolved consortia 1 . The residents within these organ systems are increasingly well characterized, yielding good understanding human microbiome composition, we have yet to elucidate full impact exerts on an animal breadth diversity it contributes 2...
Abstract The increased resistance of bacteria to clinical antibiotics is one the major dilemmas facing human health and without solutions problem will grow exponentially worse. Thiopeptide natural products have shown promising antibiotic activities provide an opportunity for development a new class antibiotics. Attempts directly translate these compounds into medicine been limited due poor physiochemical properties. synthesis core structure 26-membered thiopeptide reported using chemistry...