A5048647235- Optical Coherence Tomography Applications
- Renal and Vascular Pathologies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Renal Transplantation Outcomes and Treatments
- Cell Image Analysis Techniques
- Retinal Imaging and Analysis
- Angiogenesis and VEGF in Cancer
- Ovarian cancer diagnosis and treatment
- Photoacoustic and Ultrasonic Imaging
- Renal Diseases and Glomerulopathies
- Retinal Diseases and Treatments
University of Oklahoma
2022-2024
Abstract Cerebral microvascular health is a key biomarker for the study of natural aging and associated neurological diseases. Our aim to quantify aging‐associated change microvasculature at diverse dimensions in mice brain. We used optical coherence tomography (OCT) two‐photon microscopy (TPM) obtain nonaged aged C57BL/6J cerebral images vivo. results indicated that artery & vein, arteriole venule, capillary from showed significant differences density, diameter, complexity, perimeter,...
Human liver transplantation is severely constrained by a critical shortage of donor livers, with approximately one quarter patients on the waiting list dying due to scarcity viable organs. Current viability assessments, which rely invasive pathological methods, are hampered limited sampling from biopsies, particularly in marginal livers extended criteria donors (ECD) intended expand pool. Consequently, there pressing need for more comprehensive and non-invasive evaluation techniques meet...
Optical coherence tomography (OCT) is an ideal imaging technique for noninvasive and longitudinal monitoring of multicellular tumor spheroids (MCTS). However, the internal structure features within MCTS from OCT images are still not fully utilized. In this study, we developed cross-statistical, cross-screening, composite-hyperparameter feature processing methods in conjunction with 12 machine learning models to assess changes structure. Our results indicated that effective combined...
Multicellular tumor spheroids (MCTs) are indispensable models for evaluating drug efficacy precision cancer therapeutic strategies as well repurposing FDA-approved drugs ovarian cancer. However, current imaging techniques cannot provide effective monitoring of pathological responses due to shallow penetration and experimentally operative destruction. We plan utilize a noninvasive optical tool achieve in vivo longitudinal the growth MCTs repurpose three therapy.
We confirmed that human kidneys have various quality evaluations on different locations from histological scores. Polarization-sensitive optical coherence tomography (PS-OCT) can noninvasively provide multiple for the whole kidney feasibility of transplantation.
Kidney transplantation faces a worldwide shortage due to the lack of reliable assessment for screening qualified donor kidneys transplantation. We evaluated feasibility using polarization-sensitive optical coherence tomography (PS-OCT) provide score map covering entire surface kidney evaluate pre-transplantation quality. Multiple histology staining and two-photon microscopy (TPM) were used verification standards microstructures, tissue distributions, fibrosis in PS-OCT imaging. Our results...