Objectives. Body weight-supported treadmill training (BWSTT) is a task-specific rehabilitation strategy that enhances functional locomotion in patients following spinal cord injury (SCI). Supraspinal centers may play an important role the recovery of over-ground locomotor function with motor-incomplete SCI. The purpose this study was to evaluate potential for supraspinal reorganization associated 12 weeks robotic BWSTT using magnetic resonance imaging (fMRI). Methods. Four men SCI...

1. This investigation was designed to determine the contribution of central command resetting carotid baroreflex during static and dynamic exercise in humans. 2. Thirteen subjects performed 3.5 min one-legged (20 % maximal voluntary contraction) 7 cycling oxygen uptake) under two conditions: control (no intervention) with partial neuromuscular blockade (to increase influence) using Norcuron (curare). Carotid function determined at rest steady-state a rapid neck pressure/neck suction...

Graphical Abstract figure legend HCN channels play an evolutionarily conserved pacemaker role in renal pelvic smooth muscle (RPSM) of lower and higher order mammals. The function hyperpolarization-activated cation (HCN) pacemakers remains controversial. Renal trigger contractions that expel waste from the kidney, have been localized to these tissues. To date, however, mechanisms underlying RPSM activity remain elusive. was investigated both (top left) (bottom mammalian models, which exhibit...

1 This investigation was designed to determine the contribution of exercise pressor reflex resetting carotid baroreflex during exercise. 2 Ten subjects performed 3.5 min static one-legged (20 % maximal voluntary contraction) and 7 dynamic cycling oxygen uptake) under two conditions: control (no intervention) with application medical anti-shock (MAS) trousers inflated 100 mmHg (to activate reflex). Carotid function determined at rest using a rapid neck pressure/neck suction technique. 3...

This investigation was designed to determine the role of intramuscular pressure-sensitive mechanoreceptors and chemically sensitive metaboreceptors in affecting blood pressure response dynamic exercise humans. Sixteen subjects performed incremental (20 W/min) cycle fatigue under four conditions: control, with thigh cuff occlusion 90 Torr (Cuff occlusion), lower body positive (LBPP) 45 Torr, a combination LBPP (combination). Indexes central command (heart rate, oxygen uptake, ratings...

The present investigation was designed to uncouple the hemodynamic physiological effects of thermoregulation from a progressively increasing central command activation during prolonged exercise. Subjects performed two 1-h bouts leg cycling exercise with 1) no intervention and 2) continuous infusion dextran solution maintain venous pressure constant at 10-min pressure. Volume resulted in significant reduction decrement mean arterial seen control bout (6.7 ± 1.8 vs. 11.6± 1.3 mmHg,...

This investigation was designed to determine central command's role on carotid baroreflex (CBR) resetting during exercise. Nine volunteer subjects performed static and rhythmic handgrip exercise at 30 40% maximal voluntary contraction (MVC), respectively, before after partial axillary neural blockade. Stimulus-response curves were developed using the neck pressure-neck suction technique a rapid pulse train protocol (+40 −80 Torr). Regional anesthesia resulted in significant reduction MVC....

Background/Objective: To develop and test a clinically relevant model for predicting the recovery of over ground walking speed after 36 sessions progressive body weight-supported treadmill training (BWSTT) in individuals with motor incomplete spinal cord injury (SCI).Design: A retrospective review stepwise regression analysis SCI clinical outcomes data set.Setting: Outpatient laboratory.Subjects: Thirty who had participated locomotor BWSTT. Eight similar diagnoses were used to prospectively...

Transmission characteristics of pneumatic pressure to the carotid sinus were evaluated in 19 subjects at rest and during exercise. Either a percutaneous fluid-filled ( n = 12) or balloon-tipped catheter 7) was placed bifurcation record internal transmission external neck pressure/neck suction (NP/NS). Sustained, 5-s pulses, rapid ramping pulse protocols (+40 −80 Torr) recorded. stimuli less with compared that (65% vs. 82% negative pressure, 83% 89% positive pressure; P < 0.05). Anatomical...

We evaluated the accuracy of a novel method for recording soleus H reflex at specific points in gait cycle during robotic locomotor training subjects with spinal cord injury (SCI). Hip goniometric information from Lokomat system defined midstance and midswing within cycle. Soleus stimulation was synchronized to these robotic-assisted ambulation 1.8 2.5 km/h. Motor stimulus intensity monitored adjusted real time. Analysis 50 cycles each speed phase showed that 0.5 degrees hip joint position...

SMITH, S. A., R. G. QUERRY, P. J. FADEL, M. WELCH-O'CONNOR, A. OLIVENCIA-YURVATI, X. SHI, and B. RAVEN. Differential baroreflex control of heart rate in sedentary aerobically fit individuals. Med. Sci. Sports Exerc., Vol. 32, No. 8, pp. 1419–1430, 2000. Purpose We compared arterial, aortic, carotid-cardiac sensitivity eight average (maximal oxygen uptake, V̇O2max = 42.2 ± 1.9 mL·kg−1·min−1) high (V̇O2max 61.9 2.2 healthy young adults. Methods Arterial aortic (ABR) functions were assessed...

Regional cerebral blood flow (rCBF) in the insular cortex (IC), a well-recognized site for central pressure (BP) modulation, is decreased at minute 10 during postexercise hypotension (PEH).To determine whether exercise-induced decreases IC rCBF are associated with BP changes throughout PEH.Ten subjects were studied on three different days using counterbalanced design randomized order conditions; all tested resting baseline and then two of time points postexercise: 10, 30, 60 min. Data...

The insular cortex (IC), a region of the brain involved in blood pressure (BP) modulation, shows decreases regional cerebral flow (rCBF) during postexercise hypotension (PEH).To determine whether changes IC neural activity were caused by prior exercise or BP, this investigation compared patterns rCBF periods hypotension, which was induced (i.e., PEH) and sodium nitroprusside (SNP) infusion cold pressor (CP), to restore BP.Ten subjects studied on three different days with randomly assigned...

In Brief Ankle-foot orthoses (AFOs) are commonly prescribed to address gait dysfunction after stroke. Despite their widespread use, little is reported about the impact of AFOs on long-term motor recovery. The purpose this report was describe muscle activation patterns and characteristics three persons stroke who wore an AFO designed facilitate typical mechanics. Participants were adults (two men, one woman) admitted inpatient rehabilitation unit first-time All participants trained with a...

Eight subjects, aged 27.0+/-1.6 yr, performed incremental workload cycling to investigate the contribution of skeletal muscle mechano- and metaboreceptors ventilatory control during dynamic exercise.Each subject four bouts exercise: exercise with no intervention (CON); bilateral thigh cuffs inflated 90 mm Hg (CUFF); application lower-body positive pressure (LBPP) 45 torr (PP); cuff inflation LBPP (CUFF+PP). Ventilatory responses pulmonary gas exchange variables were collected...

Parkinson’s disease affects the ability to walk often resulting in decreased independence and low quality of life. The purpose this study was examine differences plantarflexor strength (PFS), gait speed, step length persons with (PwP) healthy peers using clinical measures. A secondary relationship between these components across severity. a convenience sample 71 PwP 25 community peers. Outcome measures included 10-Meter Walk, length, Calf-Raise Senior Test. were separated into mild moderate...

Androgen deprivation therapy (ADT) is a cornerstone of advanced prostate cancer (PCa) therapy. Its use associated with loss bone mineral density (BMD) and greater risk falls osteoporotic fractures. In this prospective cohort study, we examined the impact ADT on muscle strength in men initiating for PCa. Participants were evaluated at three time points: immediately before (week 0), 6 24 weeks after initiation. Study measures included fasting blood levels (for markers metabolic activity), MRI...

Parkinson disease (PD) is a progressive neurological resulting in motor impairments, postural instability, and gait alterations which may result self-care limitations loss of mobility reducing quality life.This study's purpose was to determine the impact community-based boxing program on parameters, dual task backwards walking individuals with PD.This study included 26 community dwelling PD who participated 12-week classes (1 hour, 2 times week). The focus upper/lower extremity exercises...

Motivation: Parkinson’s disease (PD) is a leading neurodegenerative disorder. Currently there are no medical interventions or medications to slow the progression of PD. Rehabilitation for aerobics, strength and motor control critical consider as it ameliorates symptoms, decrease falls, improves quality life. However, metabolic mechanism rehab not fully understood. Goal(s): Report evidence that, upon targeted muscle exercise training, energetics improved at cellular molecular level....