A5034514380- Sleep and related disorders
- Advanced Technologies in Various Fields
- COVID-19 and Mental Health
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- PARP inhibition in cancer therapy
- Health disparities and outcomes
- Sleep and Work-Related Fatigue
- Protein Tyrosine Phosphatases
- interferon and immune responses
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- COVID-19 diagnosis using AI
- Cytokine Signaling Pathways and Interactions
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
Fujian Medical University
2023-2025
Second Affiliated Hospital of Fujian Medical University
2023-2025
COVID-19 has been reported to affect the sleep quality of Chinese residents; however, epidemic's effects on college students during closed-loop management remain unclear, and a screening tool is lacking.This study aimed understand in Fujian Province epidemic determine sensitive variables, order develop an efficient prediction model for early problems students.From April 5 16, 2022, cross-sectional internet-based survey was conducted. The Pittsburgh Sleep Quality Index (PSQI) scale,...
In March 2022, a new outbreak of COVID-19 emerged in Quanzhou, leading to the implementation strict lockdown management measures colleges. While existing research has indicated that pandemic had significant impact on sleep quality, specific effects containment college students' patterns remain understudied. This study aimed understand quality students Fujian Province during epidemic and determine sensitive variables, order develop an efficient prediction model for early screening problems...
Age, gender, body mass index (BMI), and mean heart rate during sleep were found to be risk factors for obstructive apnea (OSA), a variety of methods have been applied predict the occurrence OSA. This study aimed develop evaluate OSA prediction models using simple accessible parameters, combined with multiple machine learning algorithms, integrate them into cloud-based mobile medicine management platform clinical use. The data obtained from records 610 patients who underwent polysomnography...
Abstract PARP1 plays a critical role in DNA repair and represents the pivotal target of first-generation PARP inhibitors to show so-called “synthetic lethal” efficacy patients with deficiency. PARP2 shares high homology PARP1, but its inhibition has been linked hematological toxicity caused by no selectivity between PARP2. AstraZeneca developed next-generation better on over PARP2, AZD5305 AZD9574, both this new class, are presently early phase clinical trials.We discovered highly selective...
Background: The sleep quality of medical staff was severely affected during COVID-19, but the factors influencing frontline involved in assistance remained unclear, and screening tools for their were lacking. Methods: From June 25 to July 14, 2022, we conducted an Internet-based cross-sectional survey. Pittsburgh Sleep Quality Index (PSQI), a self-designed general information questionnaire, questionnaire regarding combined understand Fujian Province supporting Shanghai past month. A...
Poly-ADP-ribose-polymerase 1/2 (PARP1/2) inhibitors have been approved for cancers with homologous recombination deficiency (HRD). However, their narrow therapeutic indexes largely due to hematologic toxicities limited clinical usefulness. Developing selective PARP1 has emerged as an attractive strategy achieve equivalent antitumor activity while alleviating the hematological toxicity caused by PARP2 inhibition. Herein, we report discovery of pyrazolo[1,5,4-de]quinoxalin-2(3H)-one 30 a novel...
<sec> <title>BACKGROUND</title> COVID-19 has been reported to affect the sleep quality of Chinese residents; however, epidemic’s effects on college students during closed-loop management remain unclear, and a screening tool is lacking. </sec> <title>OBJECTIVE</title> This study aimed understand in Fujian Province epidemic determine sensitive variables, order develop an efficient prediction model for early problems students. <title>METHODS</title> From April 5 16, 2022, cross-sectional...
<sec> <title>UNSTRUCTURED</title> Background: Age, gender, body mass index (BMI), and mean heart rate during sleep were found to be risk factors for obstructive apnea (OSA), a variety of methods have been applied predict the occurrence OSA. Objective: This study aimed develop evaluate OSA prediction models using simple accessible parameters, combined with multiple machine learning algorithms, integrate them into cloud-based mobile medicine management platform clinical use. Methods: The data...
<sec> <title>UNSTRUCTURED</title> Background: The prevalence of respiratory diseases has increased significantly, resulting in a rise the use high-flow nasal cannula (HFNC) therapy. However, certain limitations still exist clinical practice HFNC therapy, such as prolonged equipment training and limited healthcare resources, which can lead to unforeseen emergencies. Fortunately, with advent Internet Things (IoT) technology, great potential emerged for developing novel solutions medical...
<sec> <title>UNSTRUCTURED</title> Background: The objective of this study was to address the prevalent issue sleep disturbance among college students, which can lead a range mental and physical disorders. identification potential predictors development an accurate prediction model are essential steps for early detection appropriate intervention in disturbances. However, previous studies have encountered notable limitations. Objective: This aimed provide fresh perspective by developing...