A5053346030- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Fault Detection and Control Systems
- Single-cell and spatial transcriptomics
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Advanced Battery Technologies Research
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
- CRISPR and Genetic Engineering
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced Vision and Imaging
- Eicosanoids and Hypertension Pharmacology
- Molecular Biology Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Advanced Image Processing Techniques
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
Woomera Therapeutics
2025
Yunnan University
2024
Baylor College of Medicine
2019-2024
Chongqing Jiaotong University
2024
Tongji University
2024
Shanghai Normal University
2024
Loudi Central Hospital
2023
Qilu University of Technology
2023
Foshan Hospital of TCM
2022
University of Zurich
2018-2021
The undruggable nature of oncogenic Myc transcription factors poses a therapeutic challenge in neuroblastoma, pediatric cancer which MYCN amplification is strongly associated with unfavorable outcome. Here, we show that CYC065 (fadraciclib), clinical inhibitor CDK9 and CDK2, selectively targeted MYCN-amplified neuroblastoma via multiple mechanisms. — component the elongation complex P-TEFb bound to MYCN-amplicon superenhancer, its inhibition resulted selective loss nascent transcription. led...
Breast cancer is a leading cause of mortality among women with worldwide. Quercetin‑3‑methyl ether, natural compound occurring in various plants, has been indicated to have potent anticancer activity. cell growth and survival were examined by CCK‑8 colony formation assay, whilst cycle apoptosis determined flow cytometry. Cell invasion migration assessed wound‑healing assay Transwell assay. Cancer stem was analyzed mammosphere related signaling pathways detected western blotting. In the...
Due to traditional antibiotics’ limitations in treating tuberculosis (TB), this study presents a DNA-based nanoarchitecture that combines isoniazid and CpG via Fe2+-assisted coordination-driven self-assembly. This strategy enhances antibiotic efficacy and...
Bladder cancer (BC) is one of the most commonly diagnosed cancers globally. Recently, circular RNAs (circRNAs) have been revealed to participate in BC progression with diverse mechanisms. However, mechanisms circ_100984 not determined. Here, we found that and YBX-1 were high presented, while miR-432-3p was low presented BC. Silencing repressed tumor growth, migration, invasion vitro vivo. Mechanistically, served as a competing endogenous RNA sponged indirectly regulate epithelial-mesenchymal...
The division potential of individual stem cells and the molecular consequences successive rounds proliferation remain largely unknown. Here, we developed an inducible cell counter (iCOUNT) that reports events in human mouse tissues vitro vivo. Analyzing histories neural stem/progenitor (NSPCs) developing adult brain, show iCOUNT can provide novel insights into behavior. Further, use single-cell RNA sequencing (scRNA-seq) iCOUNT-labeled NSPCs their progenies from cortex forebrain-regionalized...
Abstract Recent developments of deep learning methods have demonstrated their feasibility in liver malignancy diagnosis using ultrasound (US) images. However, most these require manual selection and annotation US images by radiologists, which limit practical application. On the other hand, videos provide more comprehensive morphological information about masses relationships with surrounding structures than images, potentially leading to a accurate diagnosis. Here, we developed fully...
Interleukin-1β (IL-1β) is a key proinflammatory cytokine that initiates several signaling cascades, including those involving CCAAT/enhancer binding proteins (C/EBPs). The mechanism by which IL-1β propagates signal activates C/EBP has remained elusive. Nemo-like kinase (NLK) mitogen-activated protein (MAPK)-like associated with many pathways and phenotypes are not yet well understood. Using luciferase reporter screen, we found IL-1β-induced activation was positively regulated NLK....
Summary The division potential of individual stem cells and the molecular consequences successive rounds proliferation remain largely unknown. We developed an inducible cell counter (iCOUNT) that reports events in human mouse tissues vitro vivo . Analysing histories neural stem/progenitor (NSPCs) developing adult brain, we show iCOUNT allows for novel insights into behaviour. Further, used single RNA-sequencing (scRNA-seq) iCOUNT-labelled NSPCs their progenies from cortex...
Limited exploration in fungal mitochondrial genetics has uncovered diverse inheritance modes. The genomes are inherited uniparentally the majority of sexual eukaryotes, our discovery persistent heterogeneity within natural population basidiomycete fungus
Abstract Advances in preclinical models that recapitulate chemorefractory and relapsed disease are needed to better predict the efficacy of an expanding promising armamentarium drug candidates being tested early-phase pediatric clinical trials. Here, we used longitudinal magnetic resonance imaging design individualized, dose-escalating treatment regimen induces evolution neuroblastoma Th-MYCN genetically-engineered mouse model, concomitant with acquisition resistance temozolomide, a standard...
The real-time and accurate detection ranging of ships play a pivotal role in ensuring navigation safety, this study aims to enhance the safety environmental perception capabilities inland waterway vessels. In ship stage, addressing challenges such as large parameters, high computational complexity, poor performance existing models, paper proposes MS-YOLOv5s target algorithm. This algorithm, based on YOLOv5s, utilizes lightweight MobileNetV3-Small network replace original YOLOv5s feature...
To accurately predict the state of health (SOH) lithium-ion batteries and improve safety reliability battery management systems, a new SOH estimation method based on fusion features (HFs) adaptive boosting integrated grey wolf optimizer to optimize back propagation neural network (Adaboost-GWO-BP) is proposed. First, five kinds multi-type HFs were extracted from charging process, correlation between proposed was verified by Pearson Spearman coefficients. Then, indirect feature (IHF) obtained...
With the implementation of multi-lane highway lane control measures, lane-changing behavior has become more concentrated in diverging area, so it is necessary to provide a dashed solid line area an interchangeable segment for passenger cars. A model vehicle change trajectories obtained through driving simulation experiment, and length designed accordingly. Through traffic experiments, five evaluation indicators, namely, average speed, delay, rate, number rear-end conflicts, are selected from...