A5057304346- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- MicroRNA in disease regulation
- Gut microbiota and health
- Occupational and environmental lung diseases
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Acute Lymphoblastic Leukemia research
- Connexins and lens biology
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Caveolin-1 and cellular processes
- Clostridium difficile and Clostridium perfringens research
- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- Forensic and Genetic Research
- Colorectal and Anal Carcinomas
- Polyomavirus and related diseases
University of Helsinki
2014-2025
Helsinki University Hospital
2011-2025
Centre Hospitalier Universitaire de Reims
2014
Assistance Publique – Hôpitaux de Paris
2014
Université de Reims Champagne-Ardenne
2014
Sorbonne Université
2014
Université Paris-Est Créteil
2014
Inserm
2014
Clinique Hartmann
2014
Finnish Institute of Occupational Health
2004-2008
Abstract The development of tyrosine kinase inhibitor treatments has made it important to test cancer patients for clinically significant gene mutations that influence the benefit treatment. Targeted next‐generation sequencing (NGS) provides a promising method diagnostic purposes by enabling simultaneous detection multiple in various genes single test. aim our study was screen EGFR , KRAS and BRAF targeted NGS commonly used real‐time polymerase chain reaction (PCR) methods evaluate...
Microbial ecosystems that inhabit the human gut form central component of our physiology and metabolism, regulating modulating both health disease. Changes or disturbances in composition activity this microbiota can result altered immunity, inflammation, even cancer. To compare diversity stool samples from patient groups based on site neoplasm gastrointestinal tract (GIT) to assess possible contribution bacterial tumorigenesis. We studied by16S RNA gene sequencing DNA 83 patients, who were...
Abstract Background Pancreatic cancer (PC) presents a significant challenge in oncology because of its late-stage diagnosis and limited treatment options. The inadequacy current screening methods has prompted investigations into stool-based assays microbial classifiers as potential early detection markers. gut microbiota composition PC patients may be influenced by population differences, thereby impacting the accuracy disease prediction. However, comprehensive profiling analysis these...
Abstract Recent studies have shown the important role of microRNAs (miRNAs) in a variety biological processes, and its ability to distinguish tumors according their prognostic predictive properties. To identify miRNA signatures associated with colorectal carcinoma (CRC) KRAS status, we studied, using Agilent's microarrays, expression primary from 55 metastatic CRC patients, including 15 mutant 40 wild‐type KRAS. Comparing these normal colon tissue, identified 49 miRNAs—including 19 novel...
To identify microRNAs (miRNA) that predict response to anti-EGFR antibodies in patients with wild-type KRAS metastatic colorectal cancer (mCRC).miRNA profiling was performed a training set of 87 mCRC refractory chemotherapy treated antibodies. This included 33 fresh-frozen (FF) and 35 formalin-fixed paraffin-embedded (FFPE) samples retrospectively collected 19 prospectively FF samples. An independent validation cohort consisting 26 FFPE from used confirm our findings.After screening the...
Abstract Background Gastric adenocarcinoma is associated with H. pylori infection and inflammation that can result in the dysbiosis of gastric microbiota. The association intestinal microbiota subtypes or gastrointestinal stromal tumors (GIST) however not well known. Therefore, we performed 16S rRNA gene sequencing on DNA isolated from stool samples Finnish patients controls to study differences among different histological adenocarcinoma, GIST healthy controls. Results We found gut alpha...
Anaplastic lymphoma receptor tyrosine kinase ( ALK ) gene rearrangements occur in a subgroup of non-small cell lung carcinomas (NSCLCs). The identification these is important for guiding treatment decisions. aim our study was to screen fusions NSCLCs and compare the results detected by targeted resequencing with commonly used methods, including fluorescence situ hybridization (FISH), immunohistochemistry (IHC), real-time reverse transcription-PCR (RT-PCR). Furthermore, we aimed ascertain...
Colorectal cancer (CRC) is the third most common malignancy and second cause of death worldwide. Early detection CRC can improve patient survival rates; thus, identification noninvasive diagnostic markers urgently needed. MicroRNAs (miRNAs) have extensive potential to diagnose several diseases, including cancer. In this study, we compared expression pattern miRNAs from plasma stool samples patients with early stages (I, II) that healthy subjects. We performed miRNA profiling using...
Recurrent and clonal genetic alterations are characteristic of different subtypes T- B-cell lymphoblastic leukemia (ALL), several strong independent predictors clinical outcome. A next-generation sequencing–based multiplex ligation-dependent probe amplification variant (digitalMLPA) has been developed enabling simultaneous detection copy number (CNAs) up to 1000 target sequences. This novel digitalMLPA assay was designed optimized detect CNAs 56 key genes regions in ALL. set digital...
Gut microbiota plays an important role in colorectal cancer (CRC) and its composition CRC patients can be influenced by ethnicity tumour genomics. Herein, the aim was to study possible associations of gene mutations with gut patients.Bacterial stool samples 83 60 controls from Iran Finland studied 16S rRNA sequencing. The association CRC, host KRAS, NRAS TP53, analysed.Beta diversity analysis indicated significant differences between Iranian Finnish composition, both patients' groups. had...
Abstract To identify new potential diagnostic markers for lung cancer, the expression profiles of 37 tumours were analysed using cDNA arrays. Seven samples from small‐cell cancer (SCLC), two large‐cell neuroendocrine (LCNEC), and 28 other non‐small‐cell cancers (mainly squamous cell adenocarcinoma). Principal component analysis permutation test used to detect differences in gene a set genes was found that distinguished high‐grade carcinomas (SCLC LCNEC) cancers. In addition, several genes,...
Exhaled breath condensate (EBC) is a non-invasive source that can be used for studying different genetic alterations occurring in lung tissue. However, the low yield of DNA available from EBC has hampered more detailed mutation analysis by conventional methods. We applied sensitive amplicon-based next generation sequencing (NGS) to identify cancer related mutations isolated EBC. In order apply any method purpose screening patients, it important clarify incidence these healthy individuals....
Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the polyomavirus infection. Many mutational studies on MCC have been carried out in recent years without identifying a prominent driver mutation. However, there is paucity reporting expression of cancer genes at RNA level tumors. In this study, we studied profiles 26 tumors, with goal identify prospective molecular targets that could improve treatment strategies MCC. 50 cancer-related...